Ohh, Michael - University of Toronto - Department of Biochemistry

个人简介

Professor Ohh received his PhD from the University of British Columbia and was a Medical Research Council and National Cancer Institute of Canada postdoctoral fellow in the laboratory of Dr. William G. Kaelin Jr., Howard Hughes Investigator and National Academy of Science Member at the Dana-Farber Cancer Institute and Harvard Medical School. Professor Ohh is known for his pioneering and paradigm-shifting work in the field of hypoxia signalling and cancer cell biology, and has published 75 peer-reviewed articles in journals with broad readership such as Nature Medicine, Cancer Cell, EMBO Journal, Science, and Proceedings of the National Academy of Sciences with an H-index of 40, i10-index of 62 and over 10,000 total citations. Professor Ohh is a recipient of the Canadian Cancer Society’s Bernard and Francine Dorval Prize, Premier’s Research Excellence Award and Canada Research Chair in Molecular Oncology.

研究领域

Our research approach is multidisciplinary with focus on molecular biology and protein biochemistry. The research environment is highly interactive with state-of-the-art equipment and facilities and is an excellent training ground for graduate students and postdoctoral fellows who wish to pursue a career in academia. Past members have garnered competitive international and national scholarships and been recruited to prestigious institutions such as MD Anderson Cancer Center, Memorial Sloan Kettering Cancer Center, Dana-Farber Cancer Institute, Stanford, Yale, M.I.T., and Harvard.

近期论文

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Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Bunda S, Burrell K, Heir P, Zeng L, Alamsahebpour A, Kano Y, Raught B, Zhang ZY, Zadeh G, Ohh M. Nature Communications. 2015 Nov 30;6:8859. Read Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation. Bunda S, Heir P, Srikumar T, Cook JD, Burrell K, Kano Y, Lee JE, Zadeh G, Raught B, Ohh M. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3785-94. Read Hypoxia promotes ligand-independent EGFR signaling via HIF-mediated upregulation of caveolin-1. Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4892-7. *Comment in Nature Reviews Cancer. 2012 Apr;12(5):320. Read Tumor strengths and frailties: Cancer SUMmOns Otto's metabolism. Ohh M. Nature Medicine. 2012 Jan 6;18(1):30-1. Read Loss of JAK2 regulation via VHL-SOCS1 E3 ubiquitin heterocomplex underlies Chuvash polycythemia. Russell RC, Sufan RI, Zhou B, Roche O, Sybingco SS, Bunda S, Heathcote SA, Richmond TD, Heir P, Chow VWK, Hickey MM, Fuller FH, Barber DL, Cheresh DA, Simon MC, Kim WY, Irwin MS, Ohh M. Nature Medicine. 2011 Jun 19;17(7):845-53. Read NEDD8 pathways in cancer, sine quibus non. Watson IR, Irwin MS, Ohh M. Cancer Cell. 2011 Feb 15;19(2):168-76. Read Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Niemeyer CM, Kang M, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Stary J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. Nature Genetics. 2010 Sep;42(9):794-800. Read Regulation of endocytosis via the oxygen-sensing pathway. Wang Y, Roche O, Yan M, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, Marsden PA, Ohh M. Nature Medicine. 2009 Mar;15(3):319-24. *Comment in Nature Medicine. 2009 Mar;15(3):246-7. Read