Smibert, Craig A. - University of Toronto - Department of Biochemistry

个人简介

I joined the Biochemistry Department at the UofT in 1999. How did I get here? After a youth spent reading sci-fi and playing D&D, I received my Ph.D. from McMaster University in 1994 where I worked with James Smiley to understand the molecular mechanisms that regulate cellular and viral gene expression in cells infected with Herpes simplex virus. It was during this time that I developed an interest in understanding the molecular mechanisms that control mRNA translation, stability and subcellular localization. I continued to pursue this interest as a post-doctoral fellow at Stanford University in Paul Macdonald’s lab using the fruit fly embryo as a model system. While at Stanford I discovered the highly conserved Smaug family of RNA-binding proteins that they regulate the translation and stability of target mRNAs. When I’m not in the lab, I can be found hiking the Bruce Trail, traveling and following world soccer. I am also a somewhat frustrated fan of Toronto FC.

近期论文

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Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition. Laver, J.D., Li, X., Ray, D., Cook, K.B., Hahn, N.A., Nabeel-Shah, S., Kekis, M., Luo, H., Marsolais, A.J., Fung, K.Y.Y., Hughes, T.R., Westwood, J.T., Sidhu, S.S., Morris, Q., Lipshitz, H.D. and C.A. Smibert. Genome Biol. (2015) 16:94. Read Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Chen, L., Dumelie, J., Li, X., Cheng, M.H.K., Yang, Z., Laver, J.D., Siddiqui, N.U., Westwood, J.T., Morris, Q., Lipshitz, H.D. and C.A. Smibert. Genome Biol. (2014) 15:R4. Read Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity. Laver, J.D., Li, X., Ancevicius, K., Westwood, J.T., Smibert, C.A., Morris, Q., and H.D. Lipshitz. Nucleic Acids Res. (2013) 41:9438-60. Read Smaug: an unexpected journey into the mechanisms of post-transcriptional regulation. Pinder, B.D., and C.A. Smibert. Fly (2013) 7:1-4. Read microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. Pinder, B.D., and C.A. Smibert. EMBO Rep (2013) 14:80-6. Read SMAUG is the major regulator of maternal mRNA destabilization in Drosophila and is translationally activated by the PAN GU kinase. Tadros W., Goldman A.L., Babak T., Menzies F., Vardy, L., Orr-Weaver T., Hughes T.R., Westwood J.T., Smibert C.A. and H.D. Lipshitz. Developmental Cell (2007) 12:143-155. Read Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Semotok, J.L., R.L. Cooperstock, B.D. Pinder, H.K. Vari, H.D. Lipshitz and C.A. Smibert. Current Biology (2005) 15: 284-294. Read Mechanisms of Translational Regulation in Drosophila. Wilhelm, J.E. and C.A. Smibert. Biology of the Cell (2005) 97: 235-252. Read