Brown, Grant W. - University of Toronto - Department of Biochemistry

个人简介

Grant received his Ph.D. in Molecular Biology from UCLA where he worked in Dan S. Ray’s lab studying DNA replication in the trypanosomatid C. fasciculata. His postdoctoral fellowship was at the Johns Hopkins University School of Medicine in Baltimore with Tom Kelly, where he studied regulation of S phase in fission yeast. He has been at U of T since 1999, Associate Professor since 2004, and Professor since 2011.

研究领域

My lab is on the 12th floor of the Donnelly Centre, a modern, multi-disciplinary and collaborative research institute on the U of T campus. We use functional genomics techniques, including genetic interaction screens and high-throughput cell biology, to study how eukaryotic cells transmit high fidelity copies of the genome from one generation to the next. Maintaining the integrity of the genome is central to biology, and is relevant to cancer, aging, and stem cell renewal. My graduate students and postdoctoral fellows have backgrounds in biochemistry, genetics, cell biology, and computational biology. And small appliance repair.

近期论文

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours. Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. PMID: 28211448 Free PMC Article Similar articles Select item 27617677 Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci. Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ. Cell Syst. 2016 Sep 28;3(3):264-277.e10. doi: 10.1016/j.cels.2016.08.008. Epub 2016 Sep 8. PMID: 27617677 Similar articles Select item 27574117 Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. Abraham KJ, Chan JN, Salvi JS, Ho B, Hall A, Vidya E, Guo R, Killackey SA, Liu N, Lee JE, Brown GW, Mekhail K. Nucleic Acids Res. 2016 Oct 14;44(18):8870-8884. Epub 2016 Aug 29. PMID: 27574117 Free PMC Article Similar articles Select item 27373152