Kahr, Walter H.A. - University of Toronto - Department of Biochemistry

个人简介

I received my MD and PhD (Biochemistry) from the University of Toronto in 1994. Following post-graduate training in Internal Medicine at the University of Toronto (1994-1997), I completed a hematology fellowship in the Department of Medicine (1997-1999) and a post-doctoral fellowship in the Department of Pathology and Molecular Medicine (1999-2002) at McMaster University in Hamilton. During my post-doctoral fellowship I discovered that bleeding problems in patients with the rare inherited Québec platelet disorder arose from the abnormal expression of urokinase in their platelets. This information aided the effective treatment of this bleeding disorder. As a clinician-scientist at the Hospital for Sick Children I follow children with bleeding and clotting disorders. My research is focused on understanding the structure and function of platelets – the smallest cells in the blood – and how they develop from megakaryocytes, the largest cells in the bone marrow.

研究领域

My lab is located within the SickKids Research Institute Program in Cell Biology on the 19th floor of the new PGCRL building located on Bay St. in downtown Toronto.

近期论文

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Inherited macrothrombocytopenias on the rise. Landolt-Marticorena C, Kahr WH. Blood. 2014 Oct 16;124(16):2473-5. Read Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL. Blood. 2013 Nov 7;122(19):3349-58. Read The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis. Urban D, Li L, Christensen H, Pluthero FG, Chen SZ, Puhacz M, Garg PM, Lanka KK, Cummings JJ, Kramer H, Wasmuth JD, Parkinson J, Kahr WH. Blood. 2012 Dec 13;120(25):5032-40. Read Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J. Nat Genet. 2011 Jul 17;43(8):738-40. Read Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WH. Blood. 2009 Nov 12;114(20):4538-45. Read Granules and thrombus formation. Kahr WH. Blood. 2009 Jul 30;114(5):932-3. Read Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. Lo B, Li L, Gissen P, Christensen H, McKiernan PJ, Ye C, Abdelhaleem M, Hayes JA, Williams MD, Chitayat D, Kahr WH Blood. 2005 Dec 15;106(13):4159-66. Read