Julien, Jean-Philippe - University of Toronto

研究领域

Dr. Julien is interested in the structure/function study of the B cell receptor and its co-receptors. In addition to the B cell receptor (BCR), which is the precursor of the secreted antibody, the B cell possesses several unique surface molecules that are involved in regulating B cell development and function, communicating with the extracellular environment, and interpreting the BCR signal. These critical molecules have mostly remained structurally uncharacterized. Of particular interest, Dr. Julien focuses on the characterization of the BCR, and co-receptors using integrated structural and biophysical techniques. Whereas some co-receptors enhance Ca2+ responses by lowering the threshold of BCR signals, others controls follicular B cell survival and negatively regulates signaling. Careful modulation of these BCR co-receptors can therefore lead to extremely effective adjuvant strategies. A better understanding of the structure and function of these cell surface molecules, as well as those that propagate intracellular signals will not only impact our ability to design more effective vaccines, but also provide unique sites to specifically target deregulated B cells in acute lymphoblastic leukemia (B-ALL) and in autoimmune diseases, such as Rheumatoid Arthritis (RA) and Systemic lupus erythematosus (SLE).

近期论文

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Crystal structure of a soluble cleaved HIV-1 envelope trimer. Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. Science. 2013. 342(6165):1477-83. Read Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. Science. 2013. 342(6165):1484-90. Read Rational HIV immunogen design to target specific germline B cell receptors. Jardine J*, Julien JP*, Menis S*, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, Stamatatos L, Nemazee D, Wilson IA, Schief WR. Science. 2013. 340(6133):711-6. Read Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Julien JP*, Lee JH*, Cupo A, Murin CD, Derking R, Hoffenberg S, Caulfiled MC, King CR, Marozsan AJ, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Proc Natl Acad Sci U.S.A. 2013. 110(11):4351-6. Read