Moraes, Trevor F. - University of Toronto - Department of Biochemistry

个人简介

Dr. Moraes completed his undergraduate training in the Department of Biochemistry at Queen’s University in 1997 and an MSc there with Dr. William Plaxton in 1999. He obtained his PhD in 2004 at the University of Alberta, supervised by Drs. Michael Ellison and J.N.Mark Glover, followed by post-doctoral studies with Dr. Natalie Strynadka at the University of British Columbia. Dr. Moraes was hired in 2009 as an Assistant Professor and was recently awarded a Tier II Canada Research Chair in the Structural Biology of Membrane Proteins (2012). He has been an Associate Professor in the Department of Biochemistry since 2014.

近期论文

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Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria Y. Hooda, C.C. Lai, A. Judd, C. Buckwalter, H.E. Shin, S.D. Gray-Owen, and T.F. Moraes. Nature Microbiology 1 (2016). Read A method for measuring binding constants using unpurified in vivo biotinylated ligands. Anastassia K. Pogoutse, Christine C. Lai, Nick Ostan, Rong-hua Yu, Anthony B. Schryvers, Trevor F. Moraes. Anal Biochem. 2016 Feb 17. Read The molecular mechanism of Zinc acquisition by the Neisserial outer-membrane receptor ZnuD. Charles Calmettes, Christopher Ing, Carolyn M. Buckwalter, Majida El Bakkouri, Christine Chieh-Lin Lai, Pogoutse A, Scott D Gray-Owen, Régis Pomès and Trevor F. Moraes. Nature Communications 2015 Aug 18;6:7996. Read Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen. Brandon Sit, Shauna M. Crowley, Kirandeep Bhullar, Christine Chieh-Lin Lai, Calvin Tang, Yogesh Hooda, Charles Calmettes, Husain Khambati, Caixia Ma, John H. Brumell, Anthony B. Schryvers, Bruce A. Vallance, and Trevor F. Moraes. PLoS Pathog. 2015 Aug 21;11(8):e1005107. doi: 10.1371 Read Nonbinding site-directed mutants of transferrin binding protein B enhances their immunogenicity and protective capabilities. Frandoloso R, Martínez-Martínez S, Calmettes C, Fegan J, Costa E, Curran D, Yu R, Gutiérrez-Martín CB, Rodríguez Ferri EF, Moraes TF, Schryvers AB. Infect Immun. 2014 Dec 29 Read A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters. Shnitsar V, Li J, Li X, Calmettes C, Basu A, Casey JR, Moraes TF, Reithmeier RA. J Biol Chem. 2013 Nov 22;288(47):33848-60 Read The structural basis of transferrin sequestration by transferrin-binding protein B. Calmettes C, Alcantara J., Yu RH, Schryvers AB, Moraes T.F. Nat Struct Mol Biol. 2012 Feb 19;19(3):358-60. Read Bacterial receptors for host transferrin and lactoferrin: molecular mechanisms and role in host-microbe interactions. Morgenthau A, Pogoutse A, Adamiak P, Moraes TF, Schryvers AB. Future Microbiol. 2013 Dec;8(12):1575-85. Read