Howell, P. Lynne - University of Toronto - Department of Biochemistry

个人简介

Dr. Howell’s research has led to the identification of several glycosyl hydrolases that are capable of both preventing biofilm formation and degrading preformed biofilms. These enzymes are being developed as combination therapies for the treatment of a range of bacterial and fungal infections, and as disinfectants and coatings for cleaning and protecting surfaces.

研究领域

Our research activities are focused on understanding at the molecular and cellular level biological processes involved in microbial pathogenesis. The insights we gain from our fundamental research are used to develop novel strategies and treatments for bacterial and fungal biofilm related infections.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. Koo J, Lamers RP, Rubinstein JL, Burrows LL, Howell PL. Structure. 2016 Oct 4;24(10):1778-1787. doi: 10.1016/j.str.2016.08.007. Read Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms. Perrin Baker, Preston J. Hill, Brendan D. Snarr, Noor Alnabelseya, Matthew J. Pestrak, Mark J. Lee, Laura K. Jennings, John Tam, Roman A. Melnyk, Matthew R. Parsek, Donald C. Sheppard, Daniel J. Wozniak andP. Lynne Howell. Science Advances 20 May 2016: Vol. 2, no. 5, e1501632. DOI: 10.1126/sciadv.1501632 Read Modification and periplasmic translocation of the biofilm exopolysaccharide Poly-β-1,6-N-acetyl-D-glucosamine. J. Little, G. Li, C. Ing, B.R. DiFrancesco, N. Bamford, H. Robinson, M. Nitz, R. Pomès, P. L. Howell. Proc. Nat. Acad. Sci., July 3, 2014. Read P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation. P. aeruginosa SCNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation. Baker P, Ricer T, Moynihan PJ, Kitova EN, Walvoort MT, Little DJ, Whitney JC, Dawson K, Weadge JT, Robinson H, Ohman DE, Codée JD, Klassen JS, Clarke AJ, Howell PL. PLoS Pathog. 2014 10(8):e1004334. Read Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. Tammam, P. Sundaram, J. Koo, L. Sampaleanu, M. Ayers, A. Chong, J. Forman-Kay, L.L. Burrows, P. L. Howell. Mol. Micro. 82(6), 1496-1514, 2011. Read