Attisano, Liliana - University of Toronto - Department of Biochemistry

个人简介

Dr. Attisano completed her PhD at the University of Toronto and conducted post-doctoral research at Memorial Sloan-Kettering Cancer Center in NYC, NY. She currently holds a Canada Research Chair in Signalling Networks in Cancer.

研究领域

My laboratory focuses on understanding how intracellular signalling cascades receive and then transmit extracellular signals and thereby modulate complex biological responses. Current areas of particular interest are the TGFbeta, Wnt and Hippo signalling pathways, whose disruption is associated with numerous human cancers. My lab also studies pathways that regulate neuronal morphology, including the formation of axons and dendrites in primary neurons. We use mammalian cell model systems and biochemical and cell biological methods, and mouse model systems to examine how pathway disruption alters cellular and developmental processes. In addition, we use high-throughput robotics-based methods to examine the dynamics of protein-protein interactions, and to screen for alterations in signalling output using siRNA and small-molecule chemical libraries.

近期论文

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MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. Heidary Arash E, Shiban A, Song S, Attisano L. EMBO Rep. 2017 Mar;18(3):420-436. doi: 10.15252/embr.201642455. Epub 2017 Feb 9. PMID: 28183853 Similar articles Select item 28087714 DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Kwan J, Sczaniecka A, Arash EH, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V. Genes Dev. 2016 Dec 15;30(24):2696-2709. doi: 10.1101/gad.284539.116. PMID: 28087714 Similar articles Select item 26803209 Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos. Narimatsu M, Labibi B, Wrana JL, Attisano L. Differentiation. 2016 Apr-Jun;91(4-5):109-18. doi: 10.1016/j.diff.2016.01.003. Epub 2016 Jan 21. PMID: 26803209 Similar articles Select item 25425573 Arhgef7 promotes activation of the Hippo pathway core kinase Lats. Heidary Arash E, Song KM, Song S, Shiban A, Attisano L. EMBO J. 2014 Dec 17;33(24):2997-3011. doi: 10.15252/embj.201490230. Epub 2014 Nov 25. PMID: 25425573