Angers, Stephane - University of Toronto - Department of Biochemistry

个人简介

Stephane Angers is an expert in the field of signal transduction. He obtained his Ph.D from the Université de Montréal in 2002 under the guidance of Dr. Michel Bouvier. His thesis work led to the development and application of light energy transfer methodology for the study of protein-protein interaction and signal transduction. From 2002-2006 he was a Howard Hughes Post-Doctoral Fellow at the University of Washington in Seattle under the supervision of Dr. Randall T. Moon, who is a pioneer of the field of Wnt biology. In October 2006, Dr. Angers established his own research program as a member of the Department of Pharmaceutical Sciences at the Faculty of Pharmacy and in the Department of Biochemistry at the University of Toronto. He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. His research program is developed to understand the signalling mechanisms underlying the Wnt and Hedgehog families of growth factors and the large family of G protein Coupled Receptors. For this, he exploits mass spectrometry and other proteomic and genomic approaches to identify novel proteins regulating these signalling pathways and studies their functions during development, tissue homeostasis and in human diseases. Dr. Angers’ findings have been published in the most renowned scientific journals such as Nature, Science and Nature Cell Biology.

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Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis. Jockers R, Angers S, Da Silva A, Benaroch P, Strosberg AD, Bouvier M, Marullo S. The Journal of biological chemistry. 1999; 274(41):28900-8. PubMed [journal] PMID: 10506134 Select item at position 2 Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(7):3684-9. PubMed [journal] PMID: 10725388 PMCID: PMC16300 Select item at position 3 Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M. The Journal of clinical investigation. 2000; 105(7):887-95. PubMed [journal] PMID: 10749568 PMCID: PMC377482