Grinstein, Sergio - University of Toronto - Department of Biochemistry

个人简介

Sergio Grinstein completed his Ph.D. in 1976 at the Centro de Investigacion, in Mexico City. He then spent two years as a post-doctoral fellow at the Hospital For Sick Children in Toronto, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich. He is currently working at the Hospital For Sick Children in Toronto, where he was Head of the Program in Cell Biology from 1987-2007 and has been Professor of Biochemistry at the University of Toronto since 1988. Dr. Grinstein is interested in membrane biology, ion transport and the innate immune response.

研究领域

Dr. Grinstein’s group is interested in several aspects of membrane biology and signal transduction. Part of his group studies ion transport mechanisms and regulation, with particular interest in the regulation of the intracellular pH. Another sub-group studies the molecular basis of the innate immune response, mostly in macrophages. The receptors, signals and effectors that mediate phagocytosis are topics of interest, as is the interaction of pathogens with host cells.

近期论文

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Membrane phosphatidylserine regulates surface charge and protein localization. Yeung, T. Gilbert, G., Shi, J., Silvius, J., Kapus, A. and Grinstein, S. Science 319:210-213 Receptor activation alters inner surface potential during phagocytosis. Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W.M., Philips, M., Levine, T., Kapus, A. and Grinstein, S. Science 313:347-351. Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity. Fairn, G.D., Hermansson, M., Somerharju, P. and Grinstein, S. Nature Cell Biol. 13(12):1424-1430 Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Heit, B., Kim, H., Cosío, G., Castaño, D., Lowell, C.A., Kain, K.C. and Grinstein, S. Dev. Cell. 24(4):372-383 Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R.F., Peters, J., Neculai, M., Plumb, J., Loppnau, P., Pizarro, J.C., Seitova, A., Trimble, W.S., Saftig, P., Grinstein, S. and Dhe Paganon, S. Nature 504(7478):172-176 Actin cytoskeleton reorganization by the tyrosine kinase Syk regulates Fcg receptor responsiveness by increasing its lateral mobility and clustering. Jaumouillé, V., Farkash, Y., Jaqaman, K., Das, R., Lowell, C.A. and Grinstein, S. Dev. Cell 29(5):534-546