Andrews, David W. - University of Toronto - Department of Biochemistry

个人简介

Dr. Andrews has served as President of the Canadian Federation of Biological Societies and of the Canadian Society of Biochemistry, Molecular and Cellular Biology and contributed to their advocacy activities for 11 years. As part of the Partnership Group for Science and Engineering he was an invited speaker at the Canadian Parliament and has been a speaker in many public forums including Science in the City and the Canadian Cancer Society. He is a contributing member of the Faculty of 1000 (www.facultyof1000.com) and is on the editorial board of BMC Cell Biology. Dr. Andrews is active in the private sector where he was a founding partner in MBI Fermentas and a member of the Scientific Advisory Board of Isogenica Ltd., Cambridge, England. He holds two patents licensed to industry and has two additional patents submitted. Recent private sector research projects include research for PerkinElmer, Spectral Applied Research, Abbott and Genentech.

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BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Sarosiek KA, Chi X , Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW , Sorger P, Letai A. Mol Cell . 2013, 26:751-65. Read tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation. Shamas-Din A , Bindner S , Zhu W , Zaltsman Y , Campbell C , Gross A , Leber B , Andrews DW , Fradin C. J. Biol. Chem . 2013, 288: 22111-27. Read Shedding light on apoptosis at subcellular membranes. Kale J, Liu Q, Leber B, Andrews DW. Cell. 2012, 151:1179-84. doi: 10.1016/j.cell.2012.11.013. Read Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET. Liu Q , Leber B, Andrews DW . Cell Cycle . 2012, 11:3536-42. doi: 10.4161/cc.21462. Read Removing bias against membrane proteins in interaction networks. Brito GC , Andrews DW. BMC Syst Biol. 2011, 5:169. doi: 10.1186/1752-0509-5-169. Read Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. Aranovich A, Liu Q, Collins T, Geng F, Dixit S, Leber B, Andrews DW. Mol Cell. 2012, 45:754-63. doi: 10.1016/j.molcel.2012.01.030. Read