McQuibban, G. Angus - University of Toronto - Department of Biochemistry

个人简介

After completing an undergraduate degree and M.Sc. (Biochemistry) at the University of Toronto, I moved to Vancouver to pursue a Ph.D. (Biochemistry and Molecular Biology). My work focused on identifying novel substrates for a class of proteases (MMPs) that contribute to cancer metastasis. I discovered that inflammatory chemokines were a new family of substrates for this enzyme family. After completing my Ph.D. I moved to England for my PDF at the MRC-Laboratory of Molecular Biology in Cambridge. I continued my work of proteolysis, but this time working with a new family of proteases, called Rhomboids. There I revealed their important activity within mitochondria. I started my lab ‘back home’ in 2005, and since, my research interests have focused on mitochondrial quality control, and how dysregulation leads to human disease. My lab currently balances basic science projects with translational studies and small molecule screening to develop novel therapeutics in neurodegenerative disease.

研究领域

Mitochondria have long been known as ‘the powerhouse of the cell’ and while this is true, ongoing studies of mitochondrial function have revealed that these organelles orchestrate and regulate critically important signalling pathways. Not only do mitochondria regulate overall cellular metabolism, they also form an important platform for apoptosis and as such are key regulators of cellular health. In the lab, we focus on a newly identified pathway that regulates the overall health of the mitochondrial network. Mitophagy, the removal of damaged mitochondria by autophagy, is responsible for maintaining mitochondrial health. We have an intense interest in understanding how mitophagy impacts health outcomes in human neurodegenerative diseases, most notably Parkinson disease (PD). Our research focuses on the proteostasis pathways that regulate mitochondrial turnover during cellular stress. We have identified proteases that are key regulators of mitophagy, and have linked them to the eitiology of PD.

近期论文

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The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism. Shi G, McQuibban GA. Cell Rep. 2017 Feb 7;18(6):1458-1472. doi: 10.1016/j.celrep.2017.01.029. PMID: 28178523 Free Article Similar articles Select item 25915564 Deubiquitinating enzymes regulate PARK2-mediated mitophagy. Wang Y, Serricchio M, Jauregui M, Shanbhag R, Stoltz T, Di Paolo CT, Kim PK, McQuibban GA. Autophagy. 2015 Apr 3;11(4):595-606. doi: 10.1080/15548627.2015.1034408. PMID: 25915564 Free PMC Article Similar articles Select item 25784211 Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending. Rujiviphat J, Wong MK, Won A, Shih YL, Yip CM, McQuibban GA. J Mol Biol. 2015 Aug 14;427(16):2599-609. doi: 10.1016/j.jmb.2015.03.006. Epub 2015 Mar 14. PMID: 25784211 Similar articles Select item 25215488 The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Sing A, Tsatskis Y, Fabian L, Hester I, Rosenfeld R, Serricchio M, Yau N, Bietenhader M, Shanbhag R, Jurisicova A, Brill JA, McQuibban GA, McNeill H. Cell. 2014 Sep 11;158(6):1293-308. doi: 10.1016/j.cell.2014.07.036.