Adeli, Khosrow - University of Toronto - Department of Biochemistry

个人简介

Khosrow Adeli is currently a Senior Scientist in the Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto. He is also the head and full professor of Clinical Biochemistry at the Hospital for Sick Children and the Departments of Biochemistry, and Laboratory Medicine & Pathobiology at the University of Toronto in Toronto, Canada. He is the Director of Point of Care Testing program at the Hospital for Sick Children in Toronto. Dr. Adeli is a fellow of the Canadian Academy of Clinical Biochemistry and a diplomate of the American Board of Clinical Biochemistry. He is currently the Editor-in-Chief of the Critical Reviews in Clinical Laboratory Sciences. Dr. Adeli served as the Editor-in-Chief of the Clinical Biochemistry journal for 7 years (1999-2006). He is an editorial board member of the Clinical Biochemist Reviews. He served (2006-2010) as the President of COMACC, the Commission on Accreditation in Clinical Chemistry, a North American organization responsible for accreditation of clinical chemistry training programs in the USA and Canada. He currently serves as the Chair of Publications and Communications Division of the International Federation of Clinical Chemistry (IFCC). Dr. Adeli has been actively involved in both basic and clinical laboratory research since 1988 and has published over 250 articles and abstracts in the field of lipid and lipoprotein metabolism, diabetic dyslipidemia, and metabolic disorders. He has received several national and international awards for research excellence including the 2014 Distinguished Service Award of the University of Toronto, the 2011 Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology (CSATVB) Scientific Excellence Award, the 2008 Merck Senior Investigator Award of the Canadian Lipoprotein Conference, the 2006 Canadian Society of Clinical Chemistry National Award for outstanding contributions to clinical chemistry, 2004 Canadian Academy of Clinical Biochemistry National Award, and the 1999 Canadian Society of Clinical Chemistry Research Excellence Award. He has also been active in clinical chemistry research and is the principal investigator of the CALIPER (Canadian Laboratory Initiative on Pediatric Reference Interval Database) project aimed at the establishment of a laboratory reference interval database for biomarkers of pediatric disease.

研究领域

Khosorw Adeli’s basic research program is focused on the link between insulin resistant diabetes and dysregulation of lipoprotein metabolism. His group has been elucidating the molecular mechanisms linking diet-induced insulin resistance and metabolic dyslipidemia. His laboratory is employing animal models of insulin resistance to investigate the molecular mechanisms mediating the diabetogenic effect of fructose-rich diets, mechanisms of fructose-induced hepatic insulin resistance, and pathways leading to hepatic and intestinal lipogenesis and lipoprotein dysregulation.

近期论文

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GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states Hein GJ, Baker C, Hsieh J, Farr S, Adeli K Diabetes. 2013 Feb;62(2):373-81 Read Hepatic autophagy mediates ER stress-induced degradation of misfolded apolipoprotein B Qiu W, Zhang J, Dekker MJ, Wang H, Huang J, Brumell JH, Adeli K Hepatology. 2011 May;53(5):1515-25 Read Complex Biological Pattern of Fertility Hormones in Children and Adolescents: A Study of Healthy Children from the CALIPER Cohort and Establishment of Pediatric Reference Intervals Konforte D, Shea JL, Kyriakopoulou L, Colantonio D, Cohen AH, Shaw J, Bailey D, Chan MK, Armbruster D, Adeli K Clin Chem. 2013 Aug;59(8):1215-27 Read Marked Biological Variance in Endocrine and Biochemical Markers in Childhood: Establishment of Pediatric Reference Intervals Using Healthy Community Children from the CALIPER Cohort Bailey D, Colantonio D, Kyriakopoulou L, Cohen AH, Chan MK, Armbruster D, Adeli K Clin Chem. 2013 Sep;59(9):1393-405 Read Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA, Pasic MD, Armbruster D, Adeli K Clin Chem 2012, 58(5):854-68 Read