Lee, Luke P. - University of California, Berkeley

个人简介

Professor Luke P. Lee is the Arnold and Barbara Silverman Distinguished Professor of Bioengineering at the University of California, Berkeley, a Co-Director of the Berkeley Sensor & Actuator Center, and the Director of the Biomedical Institute of Global Healthcare Research & Technology (BIGHEART). Prior to joining BSAC, Professor Lee was the Chair Professor in Systems Nanobiology at the Swiss Federal Institute of Technology (ETH, Zurich) and has more than ten years of industrial experience in integrated optoelectronics, Superconducting Quantum Interference Devices (SQUIDs), and biomagnetic assays. Professor Lee is a 2010 Ho-Am Laureate and has authored and co-authored over 250 papers on bionanophotonics, microfluidics, single cell biology, quantitative biomedicine, molecular diagnostics, optofluidics, BioMEMS, biosensors, SQUIDs, SERS, and nanogap junction biosensor for label-free biomolecule detection. Professor Lee received his B.A. degree in Biophysics and his Ph.D. degree in Applied Science & Technology: Applied Physics (major) / Bioengineering (minor) from the University of California, Berkeley.

研究领域

Professor Lee’s current research interests are bionanoscience, nanomedicine for global healthcare and personalized medicine, and Bioinspired Photonics-Optofluidics-Electronics Technology and Science (BioPOETS) for green building with living skin.

近期论文

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Jun Ho Son, Byungrae Cho, SoonGweon Hong, Sang Hun Lee, Ori Hoxha, Amanda J Haack and Luke P Lee Ultrafast photonic PCR. Light: Science & Applications (2015) Ultrafast PCR Anurag Mathur, Peter Loskill, Kaifeng Shao, Nathaniel Huebsch, SoonGweon Hong, Sivan G Marcus, Natalie Marks, Mohammad Mandegar, Bruce R Conklin, Luke P Lee, Kevin E Healy Human iPSC-based cardiac Microphysiological System for drug screening applications Scientific reports(2015)Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications SoonGweon Hong, Mi Yeon Lee, Andrew O Jackson, Luke P Lee Bioinspired optical antennas: gold plant viruses. Light: Science & Applications(2015) Bioinspired optical antennas gold plant viruses Jae Young Lee, Younggeun Park, San Pun, Sung Sik Lee, Joe F Lo, Luke P Lee Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis. Nanoscale(2015) Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis Jian-Nan Wang, Yong-Lai Zhang, Yan Liu, Wanhua Zheng, Luke P Lee, Hong-Bo Sun Recent developments in superhydrophobic graphene and graphene-related materials: from preparation to potential applications. Nanoscale(2015) Jihwan Song, Minsun Song, Taewook Kang, Dongchoul Kim, Luke P Lee Label-free density difference amplification-based cell sorting. Biomicrofluidics(2014) Label-free density difference amplification-based cell sorting SungWoo Nam, Inhee Choi, Chi-cheng Fu, Kwanpyo Kim, SoonGweon Hong, Yeonho Choi, Alex Zettl, Luke P Lee Graphene nanopore with a self-integrated optical antenna.Nanoletters(2014) Graphene Nanopore with a Self-Integrated Optical Antenna Dong Wu, Jian‐Nan Wang, Li‐Gang Niu, Xu Lin Zhang, Si Zhu Wu, Qi‐Dai Chen, Luke P Lee, Hong Bo Sun Bioinspired Fabrication of High‐Quality 3D Artificial Compound Eyes by Voxel‐Modulation Femtosecond Laser Writing for Distortion‐Free Wide‐Field‐of‐View Imaging. Advanced Optical Materials(2014) Bioinspired Fabrication of High-Quality 3D Artificial Compound Eyes by Voxel-Modulation Femtosecond Laser Writing for Distortion-Free Wide-Field-of-View Imaging Hanggochnuri Jo, Daesung Yoon, Ahrum Sohn, Dong-Wook Kim, Yeonho Choi, Taewook Kang, Dukhyun Choi, Sang-Woo Kim, Luke P LeeAsymmetrically Coupled Plasmonic Core and Nanotriplet Satellites. The Journal of Physical Chemistry C(2014) Asymmetrically Coupled Plasmonic Core and Nanotriplet Satellites Shan-Shan Zhang, SoonGweon Hong, Luke P Lee, Robin M Shaw The Actin Cytoskeleton Confers Specificity of Cx43 Delivery to Intercalated Discs. Circulation Reasearch(2014) The Actin Cytoskeleton Confers Specificity of Cx43 Delivery to Intercalated Discs Hudak CS, Gulyaeva O, Wang T, Seung-min Park, Luke P. Lee, Kang C, and Sul HS. Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion. Cell Reports (2014).Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion Dukhyun Choi, Chang Kyun Shin, Daesung Yoon, Deuk Seok Chung, Yong Wan Jin, Luke P. Lee. Plasmonic Optical Interference. Nano Letters (2014).Plasmonic Optical Interference Kyuwan Lee, Yi Cui, Luke P. Lee, Joseph Irudayaraj. Quantitative imaging of single mRNA splice variants in living cells. Nature Nanotechnology 9, 474–480 (2014).Quantitative imaging of single mRNA splice variants in living cells Seung-min Park, Andrew F. Sabour, Jun Ho Son, Sang Hun Lee, Luke P. Lee. Toward Integrated Molecular Diagnostic System (iMDx): Principles and Applications. IEEE TBME (2014). Shan-Shan Zhang, SoonGweon Hong, Andre G. Kleber, Luke P. Lee, Robin M. Shaw. A micropatterning approach for imaging dynamic Cx43 trafficking to cell–cell borders. FEBS Letters 588, 1439–1445 (2014).A micropatterning approach for imaging dynamic Cx43 trafficking to cell–cell borders Ivan K. Dimov, Rong Lu, Eric P. Lee, Jun Seita, Debashis Sahoo, Seung-min Park, Irving L. Weissman, Luke P. Lee. Discriminating cellular heterogeneity using microwell-based RNA cytometry. Nature Communications 5, (2014).Discriminating cellular heterogeneity using microwell-based RNA cytometry Sang Hun Lee, Seung-min Park, Luke P. Lee Optical Methods in Studies of Olfactory System. Bioelectronic Nose 191–220, (Springer Netherlands, 2014). Jun Ho Son, Sang Hun Lee, Soongweon Hong, Seung-min Park, Joseph Lee, Andrew M. Dickey, Luke P. Lee. Hemolysis-free blood plasma separation. Lab on a Chip 14, 2287–2292 (2014).Hemolysis-free blood plasma separation Ryan D. Sochol, Albert Lu, Jonathan Lei, Kosuke Iwai, Luke P. Lee, Liwei Lin. Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications. Lab on a Chip 14, 1585–1594 (2014).Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications Ryan D. Sochol, Daniel Corbett, Sarah Hesse, William ER Krieger, Ki Tae Wolf, Minkyu Kim, Kosuke Iwai, Song Li, Luke P. Lee, Liwei Lin. Dual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors. Lab on a Chip 14, 1405–1409 (2014).TDual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors Sung Sik Lee, Luke P. Lee. Noninvasive label-free nanoplasmonic optical imaging for real-time monitoring of in vitro amyloid fibrogenesis. Nanoscale 6, 3561–3565 (2014).Noninvasive label-free nanoplasmonic optical imaging for real-time monitoring of in vitro amyloid fibrogenesis Kyungsuk Yum, Soon Gweon Hong, Kevin E. Healy, Luke P. Lee. Physiologically relevant organs on chips. Biotechnology Journal 9, 16–27 (2014). Inhee Choi, Elizabeth Lee, Luke P. Lee. Current nano/biotechnological approaches in amyotrophic lateral sclerosis. Biomedical Engineering Letters. 3(4), 209-222 (2013). Myers, Frank B., Jason S. Silver, Yan Zhuge, Ramin E. Beygui, Christopher K. Zarins, Luke P. Lee, and Oscar J. Abilez. Robust Pluripotent Stem Cell Expansion and Cardiomyocyte Differentiation via Geometric Patterning. Integrative Biology, 2013, 5 (12), 1495–1506. Maria Paz Gutierrez, Luke P. Lee, Multiscale Design and Integration of Sustainable Building Functions, Science, 2013, 341 (6143), 247-248. Jun Ho Son, Byungrae Cho, SoonGweon Hong, Sang Hun Lee, Ori Hoxha, Amanda J Haack and Luke P Lee Ultrafast photonic PCR. Light: Science & Applications (2015) Ultrafast PCR Anurag Mathur, Peter Loskill, Kaifeng Shao, Nathaniel Huebsch, SoonGweon Hong, Sivan G Marcus, Natalie Marks, Mohammad Mandegar, Bruce R Conklin, Luke P Lee, Kevin E Healy Human iPSC-based cardiac Microphysiological System for drug screening applications Scientific reports(2015)Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications SoonGweon Hong, Mi Yeon Lee, Andrew O Jackson, Luke P Lee Bioinspired optical antennas: gold plant viruses. Light: Science & Applications(2015) Bioinspired optical antennas gold plant viruses Jae Young Lee, Younggeun Park, San Pun, Sung Sik Lee, Joe F Lo, Luke P Lee Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis. Nanoscale(2015) Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis Jian-Nan Wang, Yong-Lai Zhang, Yan Liu, Wanhua Zheng, Luke P Lee, Hong-Bo Sun Recent developments in superhydrophobic graphene and graphene-related materials: from preparation to potential applications. Nanoscale(2015) Jihwan Song, Minsun Song, Taewook Kang, Dongchoul Kim, Luke P Lee Label-free density difference amplification-based cell sorting. Biomicrofluidics(2014) Label-free density difference amplification-based cell sorting SungWoo Nam, Inhee Choi, Chi-cheng Fu, Kwanpyo Kim, SoonGweon Hong, Yeonho Choi, Alex Zettl, Luke P Lee Graphene nanopore with a self-integrated optical antenna.Nanoletters(2014) Graphene Nanopore with a Self-Integrated Optical Antenna Dong Wu, Jian‐Nan Wang, Li‐Gang Niu, Xu Lin Zhang, Si Zhu Wu, Qi‐Dai Chen, Luke P Lee, Hong Bo Sun Bioinspired Fabrication of High‐Quality 3D Artificial Compound Eyes by Voxel‐Modulation Femtosecond Laser Writing for Distortion‐Free Wide‐Field‐of‐View Imaging. Advanced Optical Materials(2014) Bioinspired Fabrication of High-Quality 3D Artificial Compound Eyes by Voxel-Modulation Femtosecond Laser Writing for Distortion-Free Wide-Field-of-View Imaging Hanggochnuri Jo, Daesung Yoon, Ahrum Sohn, Dong-Wook Kim, Yeonho Choi, Taewook Kang, Dukhyun Choi, Sang-Woo Kim, Luke P LeeAsymmetrically Coupled Plasmonic Core and Nanotriplet Satellites. The Journal of Physical Chemistry C(2014) Asymmetrically Coupled Plasmonic Core and Nanotriplet Satellites Shan-Shan Zhang, SoonGweon Hong, Luke P Lee, Robin M Shaw The Actin Cytoskeleton Confers Specificity of Cx43 Delivery to Intercalated Discs. Circulation Reasearch(2014) The Actin Cytoskeleton Confers Specificity of Cx43 Delivery to Intercalated Discs Hudak CS, Gulyaeva O, Wang T, Seung-min Park, Luke P. Lee, Kang C, and Sul HS. Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion. Cell Reports (2014).Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion Dukhyun Choi, Chang Kyun Shin, Daesung Yoon, Deuk Seok Chung, Yong Wan Jin, Luke P. Lee. Plasmonic Optical Interference. Nano Letters (2014).Plasmonic Optical Interference Kyuwan Lee, Yi Cui, Luke P. Lee, Joseph Irudayaraj. Quantitative imaging of single mRNA splice variants in living cells. Nature Nanotechnology 9, 474–480 (2014).Quantitative imaging of single mRNA splice variants in living cells Seung-min Park, Andrew F. Sabour, Jun Ho Son, Sang Hun Lee, Luke P. Lee. Toward Integrated Molecular Diagnostic System (iMDx): Principles and Applications. IEEE TBME (2014). Shan-Shan Zhang, SoonGweon Hong, Andre G. Kleber, Luke P. Lee, Robin M. Shaw. A micropatterning approach for imaging dynamic Cx43 trafficking to cell–cell borders. FEBS Letters 588, 1439–1445 (2014).A micropatterning approach for imaging dynamic Cx43 trafficking to cell–cell borders Ivan K. Dimov, Rong Lu, Eric P. Lee, Jun Seita, Debashis Sahoo, Seung-min Park, Irving L. Weissman, Luke P. Lee. Discriminating cellular heterogeneity using microwell-based RNA cytometry. Nature Communications 5, (2014).Discriminating cellular heterogeneity using microwell-based RNA cytometry Sang Hun Lee, Seung-min Park, Luke P. Lee Optical Methods in Studies of Olfactory System. Bioelectronic Nose 191–220, (Springer Netherlands, 2014). Jun Ho Son, Sang Hun Lee, Soongweon Hong, Seung-min Park, Joseph Lee, Andrew M. Dickey, Luke P. Lee. Hemolysis-free blood plasma separation. Lab on a Chip 14, 2287–2292 (2014).Hemolysis-free blood plasma separation Ryan D. Sochol, Albert Lu, Jonathan Lei, Kosuke Iwai, Luke P. Lee, Liwei Lin. Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications. Lab on a Chip 14, 1585–1594 (2014).Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications Ryan D. Sochol, Daniel Corbett, Sarah Hesse, William ER Krieger, Ki Tae Wolf, Minkyu Kim, Kosuke Iwai, Song Li, Luke P. Lee, Liwei Lin. Dual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors. Lab on a Chip 14, 1405–1409 (2014).TDual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors Sung Sik Lee, Luke P. Lee. Noninvasive label-free nanoplasmonic optical imaging for real-time monitoring of in vitro amyloid fibrogenesis. Nanoscale 6, 3561–3565 (2014).Noninvasive label-free nanoplasmonic optical imaging for real-time monitoring of in vitro amyloid fibrogenesis Kyungsuk Yum, Soon Gweon Hong, Kevin E. Healy, Luke P. Lee. Physiologically relevant organs on chips. Biotechnology Journal 9, 16–27 (2014). Inhee Choi, Elizabeth Lee, Luke P. Lee. Current nano/biotechnological approaches in amyotrophic lateral sclerosis. Biomedical Engineering Letters. 3(4), 209-222 (2013). Myers, Frank B., Jason S. Silver, Yan Zhuge, Ramin E. Beygui, Christopher K. Zarins, Luke P. Lee, and Oscar J. Abilez. Robust Pluripotent Stem Cell Expansion and Cardiomyocyte Differentiation via Geometric Patterning. Integrative Biology, 2013, 5 (12), 1495–1506. Maria Paz Gutierrez, Luke P. Lee, Multiscale Design and Integration of Sustainable Building Functions, Science, 2013, 341 (6143), 247-248.