研究领域

Physical and Biochemistry

Research in the Lorieau group integrates Biophysics, Physical Chemistry, Structural Biology and Biochemistry in elucidating the interplay between biomolecular structure, dynamics, chemistry and function. With a combination of solution- and solid-state Nuclear Magnetic Resonance spectroscopies, computational tools and other biophysical methods, our research focuses on membrane protein structure and dynamics, membrane protein biochemistry, the development of theory and techniques to enhance the precision and resolution of structural and dynamic information by NMR, and the investigation of molecular dynamics as it relates to enzymatic catalysis and kinetics.

近期论文

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Smrt ST, Draney AW, Lorieau JL. (2014) The Influenza Hemagglutinin Fusion Domain is an Amphipathic Helical-Hairpin that Functions by Inducing Membrane Curvature. J Biol Chem 290: 228-238. (DOI: 10.1074/jbc.M114.611657) Eichmann C, Orts J, Tzitzilonis C, Vögeli BR, Smrt ST , Lorieau JL, and Riek R. Intermolecular Detergent – Membrane Protein NOEs for the Characterization of Dynamics of Membrane Protein-Detergent Complexes. (2014) J Phys Chem B 118: 14288-14301. (DOI: 10.1021/jp509137q) Draney AW, Smrt ST, Lorieau JL. (2014) Use of Isotropically Tumbling Bicelles to Measure Curvature Induced by Membrane Components. Langmuir 30: 11723–11733. (DOI: 10.1021/la5030668) Lorieau JL, Maltsev AS, Louis JM, and Bax A (2013) Modulating alignment of membrane proteins in liquid-crystalline and oriented gel media by changing the size and charge of phospholipid bicelles. J. Biomol. NMR. 55, 369-377 (DOI: 10.1007/s10858-013-9720-3) Lorieau JL, Louis JM, Schwieters CD, Bax A (2012) pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR. Proc Nat'l Acad Sci USA 109:19994-19999. (DOI) Lorieau JL, Louis JM, Bax A (2012) The impact of influenza hemagglutinin fusion peptide length and viral subtype on its structure and dynamics. Biopolymers. (DOI) Lorieau JL, Louis JM, Bax A (2011) Whole-Body Rocking Motion of a Fusion Peptide in Lipid Bilayers from Size-Dispersed 15N NMR Relaxation. J Am Chem Soc 133:14184-14187. (DOI) Lorieau JL, Louis JM, Bax A (2011) Helical Hairpin Structure of Influenza Hemagglutinin Fusion Peptide Stabilized by Charge−Dipole Interactions between the N-Terminal Amino Group and the Second Helix. J Am Chem Soc 133: 2824-2827. (DOI) Lorieau JL, Louis JM, Bax A (2010) The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface. Proc Nat’l Acad Sci USA 107:11341-11346. (DOI) Xu YM, Lorieau JL, McDermott, AE (2010) Triosephosphate Isomerase: N-15 and C-13 Chemical Shift Assignments and Conformational Change upon Ligand Binding by Magic-Angle Spinning Solid-State NMR Spectroscopy. J Mol Biol 397:233-248. (DOI) Lorieau JL, Yao L, Bax A (2008) Liquid crystalline phase of G-tetrad DNA for NMR study of detergent-solubilized proteins. J Am Chem Soc 130:7536-7537. (DOI) Lorieau JL, Day LA, McDermott AE (2008) Conformational dynamics of an intact virus: Order parameters for the coat protein of Pf1 bacteriophage. Proc Nat’l Acad Sci USA 105:10366-10371. (DOI) Lorieau JL, McDermott AE (2006) Conformational Flexibility of a Microcrystalline Globular Protein : Order Parameters by Solid-State NMR. J Am Chem Soc 128:11505-11512. (DOI) Lorieau JL, McDermott AE (2006) Order Parameters Based on 13C1H, 13C1H2 and 13C1H3 Heteronuclear Dipolar Powder Patterns: A Comparison of MAS-Based Solid-State NMR Sequences. Magn Reson Chem 44:334-347. (DOI) Lorieau JL (2006) Protein Dynamics : Solid-state NMR and Computational Studies (PhD Dissertation). Columbia University. Shoemaker GK, Lorieau JL, Lau LH, Gillmore CS, Palcic MM (2005) Multiple Sampling in Single-Cell Enzyme Assays Using CE-Laser-Induced Fluorescence to Monitor Reaction Progress. Anal Chem 77:3132-3137. (DOI) Lorieau JL, Shoemaker GK, Palcic MM (2003) Quantitative Nanopipettor for Miniaturized Chemical and Biochemical Reaction Sampling. Anal Chem 75:6351-6354. (DOI) Gillmor CS, Poindexter P, Lorieau JL, Palcic MM, Somerville C (2002) Alpha-Glucosidase I is Required for Cellulose Biosynthesis and Morphogenesis in Arabidopsis. J Cell Biol 156:1003-1013. (DOI)