仰大勇 - 天津大学

个人简介

Dayong Yang is a Principal Investigator at Tianjin University. He received his BS and MS degrees with Professor Xiaolin Xie at Huazhong University of Science and Technology in 2002 and 2005, respectively. In 2008, he received PhD degree with Professor Xingyu Jiang at the National Center for Nanoscience and Technology. He did postdoctoral training at Cornell University in USA with Professor Dan Luo and Radboud University Nijmegen in Netherlands with Professor Wilhelm Huck. In 2015, he joined in the School of Chemical Engineering and Technology of Tianjin University as a full professor. The themes of his research include DNA-based materials, bio-functional polymers, cancer imaging, diagnostics and therapeutics, and synthetic biology.

研究领域

Our research integrates material chemistry and chemical biology to program new functional materials for healthcare and explore the chemical basis of life. Our major research interests include: (i) Nucleic acid chemistry (ii) Smart functional materials made from DNA (iii) Advanced tumor diagnosis and treatment technology (iv) Synthetic biology

近期论文

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Yanfei Guo+, Zhaobin Tong+, Yan Huang, Jianpu Tang, Xue Xue, Dayong Yang*, Chi Yao*, Dynamic Assembly of DNA Nanostructures in Cancer Cells Enables the Coupling of Autophagy Activating and Real-Time Tracking. Nano Letters, 2024. Sen Yang+, Yu Cheng+, Mingxing Liu, Jianpu Tang, Siqi Li, Yan Huang, Xiaohong Kou*, Chi Yao*, Dayong Yang*, Sequential Assembly of DNA Nanoparticles inside Cells Enables Lysosome Interference and Cell Behavior Regulation. Nano Today, 2024, 56, 102224. Jianpu Tang+, Jing Wang+, Junhan Ou+, Zhen Cui, Chi Yao*, Dayong Yang*, A DNA/Poly-(L-lysine) Hydrogel with Long Shelf-Time for 3D Cell Culture. Small Methods, 2024. Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A Smart DNA Hydrogel Enables Synergistic Immunotherapy and Photodynamic Therapy of Melanoma. Angewandte Chemie International Edition, 2024. Jinqiao Liu+, Yuhang Dong+, Jianpu Tang, Junlin Wu, Yan Huang, Chi Yao*, Dayong Yang*, A DNA Nanocomplex with Bifunctions of Reactive Oxygen Species Scavenging and Gene Silencing for Synergistic Repair of Myocardial Infarction. Nano Today, 2024, 55, 102185. Sen Yang+, Siqi Li+, Chi Yao*, Dayong Yang*, Controlled Assembly of Exogenous DNA-Based Materials in Living Cells. Fundamental Research, 2024,. Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/Upconversion Nanoparticle Complex Enables Controlled Co-Delivery of CRISPR-Cas9 and Photodynamic Agents for Synergistic Cancer Therapy. Advanced Materials, 2024, 2309534. Meihe Yuan+, Yuhang Dong+, Zhaoyue Lv+, Jinqiao Liu, Mingxing Liu, Mengdi Xu, Xiaocui Guo*, Chi Yao*, Dayong Yang*, Controlled Sequential Assembly of DNA Nanoparticles inside Cells Enabling Mitochondrial Interference. Advanced Functional Materials, 2023, 2312880. Feng Li+*, Xiaohui Ding+, Zhaoyue Lv, Jing Li, Dayong Yang*, A DNA-Polymer Hybrid Nanocomplex Based Bi-Adjuvant Vaccine for Tumor Immunotherapy. Nano Today, 2024, 54, 102061, 1748. Zhaoyue Lv+, Zhemian Li+, Shaolan Zou+, Peiran Li, Nachuan Song, Rui Zhang, Mengdi Xu, Mingxing Liu, Fengqin Li, Junru Li, Peifeng Liu*,Chi Yao*, Dayong Yang*, A Smart DNA Nanoassembly Containing Multivalent Aptamers Enables Controlled Delivery of CRISPR/Cas9 for Cancer Immunotherapy. Advanced Functional Materials, 2023, 2311069. Rui Zhang+, Pin Hu+, Yuwei Xu, Ziqing Wang, Dayong Yang*, Chi Yao*， Light-Mediated Spatiotemporally Dynamic Assembly of DNA Nanostructures in Living Cells Regulates Autophagy. CCS Chemistry, 2023, ccschem.023.202303271. Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-Mediated Self-Assembly of DNA Network in Cancer Cells Enabling Mitochondrial Interference. Journal of the American Chemical Society, 2023, 145, 43, 23859. Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade Dynamic Assembly/Disassembly of DNA Nanoframework Enabling the Controlled Delivery of CRISPR-Cas9 System. Science Advances, 2023, 9, eadi3602. Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A Smart DNA-Based Nanosystem Containing Ribosome-Regulating siRNA for Enhanced mRNA Transfection. Advanced Materials, 2023, 2300823. Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-based hydrogel for exosome separation and biomedical applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120. Nachuan Song, Yiwen Chu, Shuai Li, Xiaoting Fan, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Peifeng Liu*, A Dual-Enzyme-Responsive DNA-Based Nanoframework Enables Controlled Co-Delivery of CRISPR-Cas9 and Antisense Oligodeoxynucleotide for Synergistic Gene Therapy. Advanced Functional Materials, 2023, 2306634. Fengqin Li+, Junru, Li+, Weiqiang Yang+, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*, Framework-Hotspot Enhanced Trans Cleavage of CRISPR-Cas12a for Clinical Samples Detection. Angewandte Chemie International Edition, 2023, e202305536. Chi Yao+,*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic Assembly of DNA-ceria Nanocomplex in Living Cells Generates Artiﬁcial Peroxisome. Nature Communications, 2022, 13, 7739. Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis. Accounts of Chemical Research, 2022, 15, 2043. Yuhang Dong+, Feng Li+, Zhaoyue Lv, Shuai Li, Meihe Yuan, Nachuan Song, Jinqiao Liu, Dayong Yang*, Lysosome Interference Enabled by Proton-Driven Dynamic Assembly of DNA Nanoframework inside Cells. Angewandte Chemie International Edition, 2022, 61, e202207770. Feng Li+, Yujie Liu+, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang*, Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference. Journal of the American Chemical Society, 2022, 144, 4667. Feng Li+, Nachuan Song+, Yuhang Dong, Shuai Li, Linghui Li, Yujie Liu, Zhemian Li, Dayong Yang*, A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy. Angewandte Chemie International Edition, 2022, 61, e202116569. Huaixin Zhao+, Linghui Li+, Feng Li*, Chunxia Liu, Mengxue Huang, Jiao Li, Feng Gao, Xinhua Ruan, Dayong Yang*, An Energy Stored DNA-based Nanocomplex for Laser-free Photodynamic Therapy. Advanced Materials, 2022, 34, 2109920. Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA Nanocomplex Containing Cascade DNAzymes and Promoter-Like Zn-Mn-Ferrite for Combined Gene/Chemo-dynamic Therapy. Angewandte Chemie International Edition, 2022, 61, e202113619. Jianpu Tang, Junhan Ou, Chenxu Zhu, Chi Yao*, Dayong Yang*, Flash Synthesis of DNA Hydrogel via Supramacromolecular Assembly of DNA Chains and Upconversion Nanoparticles for Cell Engineering. Advanced Functional Materials, 2022, 32, 2107267. Chi Yao+, Jianpu Tang+, Chenxu Zhu, Sen Yang, Han Tang, Luxi Dong, Chunzhi Zhang, Qianyun Tang, Peifeng Liu*, Dayong Yang*, A Signal Processor Made from DNA Assembly and Upconversion Nanoparticle for Pharmacokinetic Study. Nano Today, 2022, 42, 101352. Chi Yao, Yuwei Xu, Pin Hu, Junhan Ou, Dayong Yang*, Gene-like Precise Construction of Functional DNA Materials. Accounts of Materials Research, 2022, 3, 42. Jinpeng Han, Yanfei Guo, Hang Wang, Kunyu Zhang, Dayong Yang*, Sustainable Bioplastic Made from Biomass DNA and Ionomers. Journal of the American Chemical Society, 2021, 143, 19486. Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T Lymphocyte-captured DNA Network for Localized Immunotherapy. Journal of the American Chemical Society, 2021, 143, 19330. Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling Circle Amplification (RCA)-based DNA Hydrogel. Nature Protocols, 2021, 16, 5460. Feng Li+, Wenting Yu+, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang*, Spatiotemporally Programmable Cascade Hybridization of Hairpin DNA in Polymeric Nanoframework for Precise siRNA Delivery. Nature Communications, 2021, 12, 1138. Feng Li+, Zhaoyue Lv+, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang*, Supramolecular Self-assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer cells. Angewandte Chemie International Edition, 2021, 133, 25761. Jinpeng Han, Yuchen Cui, Zi Gu, Dayong Yang*, Controllable Assembly/Disassembly of Polyphenol-DNA Nanocomplex for Cascade-responsive Drug Release in Cancer cells. Biomaterials, 2021, 273, 120846. Huaixin Zhao+, Zhili Zhang+, Duo Zuo+, Linghui Li, Feng Li*, Dayong Yang*, A Synergistic DNA-polydopamine-MnO2 Nanocomplex for Near-infrared Light Powered DNAzyme-mediated Gene Therapy. Nano Letters, 2021, 21, 5477. Jinpeng Han, Yuchen Cui, Feng Li, Zi Gu, Dayong Yang*, Responsive Disassembly of Nucleic Acid Nanocomplex in Cells for Precision Medicine. Nano Today, 2021, 39, 101160. Huaixin Zhao+, Jigang Lv+, Feng Li, Zhili Zhang, Chunzhi Zhang, Zi Gu, Dayong Yang*, Enzymatical Biomineralization of DNA Nanoflowers Mediated by Manganese Ions for Tumor Site Activated Magnetic Resonance Imaging. Biomaterials, 2021, 268, 120591. Chi Yao+, Weijian Wu+, Han Tang, Xuemei Jia, Jianpu Tang, Xinhua Ruan, Feng Li, David Tai Leong, Dan Luo, Dayong Yang*, Self-assembly of Stem Cell Membrane-Camouflaged Nanocomplex for MicroRNA-Mediated Repair of Myocardial Infarction Injury. Biomaterials, 2020, 257, 120256. Huaixin Zhao+, Huiting Zhao+, Yi Jiao, Yi Zhu, Chunxia Liu, Feng Li, Yinsong Wang, Zi Gu, Dayong Yang*, Biosynthetic Molecular Imaging Probe for Tumor-targeted Dual-modal Fluorescence/magnetic Resonance Imaging,. Biomaterials, 2020, 256, 120220. Yuhang Dong+, Chi Yao+, Yi Zhu, Lu Yang, Dan Luo, and Dayong Yang*, DNA Functional Materials Assembled from Branched DNA: Design, Synthesis and Applications. Chemical Reviews, 2020, 120, 9420. Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double Rolling Circle Amplification Generates Physically Crosslinked DNA Network for Stem Cell Fishing. Journal of the American Chemical Society, 2020, 142, 3422. Dong Wang, Jinhui Cui, Mingzhe Gan, Zhaohui Xue, Jing Wang, Peifeng Liu, Yue Hu, Yehudah Pardo, Shogo Hamada, Dayong Yang*, Dan Luo*, Transformation of Biomass DNA into Biodegradable Materials from Gels to Plastics for Reducing Petrochemical Consumption. Journal of the American Chemical Society, 2020, 142, 10114. Xiaocui Guo+, Feng Li+, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*, Construction of Organelle-like Architecture by Dynamic DNA Assembly in Living Cells. Angewandte Chemie International Edition, 2020, 59, 20651. Feng Li+, Shuai Li+, Xiaocui Guo, Yuhang Dong, Chi Yao, Yangping Liu, Yuguang Song, Xiaoli Tan, Lizeng Gao, Dayong Yang*, Chiral Carbon Dots Mimicking Topoisomerase I to Enantioselectively Mediate Topological Rearrangement of Supercoiled DNA Enantioselectively. Angewandte Chemie International Edition, 2020, 59, 11087. Jianpu Tang+, Chi Yao+, Zi Gu, Sunghwan Jung, Dan Luo, Dayong Yang*, Super-soft and Super-elastic DNA Robot with Magnetically-driven Navigational Locomotion for Cell Delivery in Confined Space. Angewandte Chemie International Edition, 2020, 59, 2490. Jinpeng Han+, Yuchen Cui+, Xinpeng Han, Chenyu Liang, Wenguang Liu, Dan Luo, Dayong Yang*, Super-soft DNA/Dopamine-grafted-dextran Hydrogel as Dynamic Wire for Electric Circuits Switched by a Microbial Metabolism Process. Advanced Science, 2020, 7, 2000684. Renkuan Liao, Feng Zhao, Shogo Hamada, Peiling Yang, Huan Xu, Dan Luo*, Dayong Yang*, DNA-based Engineering System for Improving Human and Environmental Health: Identification, Detection, and Treatment. Nano Today, 2020, 35, 100958. Huaixin Zhao+, Chunxia Liu+, Zi Gu, Luxi Dong, Feng Li, Chi Yao, Dayong Yang*, Persistent Luminescent Nanoparticles Containing Hydrogel for Targeted, Sustained and Autofluorescence-free Tumor Metastasis Imaging. Nano Letters, 2020, 20, 252. Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*, Gene Circuit Compartment on Nanointerface Facilitatating Cascade Gene Expression. Journal of the American Chemical Society, 2019, 141, 19171. Feng Li+, Jianpu Tang+, Jinhui Geng, Dan Luo, Dayong Yang*, Polymeric DNA Hydrogel: Design, Synthesis and Applications. Progress in Polymer Science, 2019, 98, 101163. Jinpeng Han, Likun Xiong, Xingyu Jiang, Xiaoyan Yuan*, Yong Zhao*, Dayong Yang*, Bio-functional Electrospun Nanomaterials: from Topology Design to Biological Applications. Progress in Polymer Science, 2019, 91, 1. Huaixin Zhao+*, Gang Shu+, Jinye Zhu, Yanyan Fu, Zi Gu, Dayong Yang*, Persistent Luminescent Metal-Organic Frameworks with Long-Lasting Near Infrared Emission for Tumor Site Activated Imaging and Drug Delivery. Biomaterials, 2019, 217, 119332. Ke Meng+, Chi Yao+, Qianmin Ma, Zhaohui Xue, Yaping Du, Wenguang Liu, Dayong Yang*, A Reversibly Responsive Fluorochromic Hydrogel Based on Lanthanide-mannose Complex. Advanced Science, 2019, 6, 1802112.