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Lu, Z.; Ju, M.; Wang, Y.; Meinhardt, J. M.; Martinez Alvarado, J. I.; Villemure, E.; Terrett, J. A.; Lin, S.* “Regioselective Aliphatic C–H Functionalization Using Frustrated Radical Pairs.” Nature 2023, accepted.
Rein, J.; Rozema, S. D.; Langner, O. C.; Zacate, S. B.; Hardy, M. A.; Siu, J. C.; Mercado, B. Q.; Sigman, M. S.*; Miller, S. J.*; Lin, S.* “Generality-Oriented Optimization of Enantioselective Aminoxyl Radical Catalysis.” Science 2023, 380, 706–712. DOI: 10.1126/science.adf6177 [html]
Guan, W.; Lu, L.; Jiang, Q.; Gittens, A. F.; Wang, Y.; Novaes, L. F. T.; Klausen, R. S.*; Lin, S.* “An Electrochemical Strategy to Synthesize Disilanes and Oligosilanes from Chlorosilanes.” Angew. Chem., Int. Ed. 2023, DOI: 10.1002/anie.202303592. [html]
Rein, J.; Meinhardt, J. M.; Hofstra Wahlman, J. L.; Sigman, M. S.*; Lin, S.* “A Physical Organic Approach towards Statistical Modeling of Tetrazole and Azide Decomposition.” Angew. Chem., Int. Ed. 2023, DOI: 10.1002/anie.202218213. [html]
Wood, D.; Lin, S.* “Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis.” Angew. Chem., Int. Ed. 2023, DOI: 10.1002/anie.202218858.
Sun, G.-Q.; Yu, P.; Zhang, W.; Zhang, W.; Wang, Y.; Liao, L.-L.; Zhang, Z.; Li, L.; Lu, Z.; Yu, D.-G.; Lin, S. “Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations.” Nature 2023. DOI: 10.1038/s41586-022-05667-0
Tran, V. T.; Kim, N.; Rubel, C. Z.; Wu, X.; Kang, T.; Jankins, T. C.; Li, Z.-Q.; Joannou, M. V.; Ayers, S.; Gembicky, M.; Bailey, J.; Sturgell, E. J.; Sanchez, B. B.; Chen, J. S.; Lin, S.; Eastgate, M. D.; Wisniewski, S. R.; Engle, K. M. “Structurally Diverse Bench-Stable Nickel(0) Pre-Catalysts: A Practical Toolkit for In Situ Ligation Protocols.” Angew. Chem., Int. Ed. 2022, e202211794. DOI: 10.1002/anie.202211794
Rein, J.; Lin, S.; Kalyani, D.; Lehnherr, D. High-Throughput Experimentation for Electrochemistry. In The Power of High-Throughput Experimentation: General Topics and Enabling Technologies for Synthesis and Catalysis; Emmert, M. H., Jouffroy, M., Leitch, D. C., Eds; ACS Symposium Series, Vol. 1419; American Chemical Society, 2022; pp 167–187. DOI: 10.1021/bk-2022-1419.ch010
Novaes, L. F. T.; Wang, Y.; Liu, J.; Riart-Ferrer, X.; Lee, W.-C. C.; Fu, N.; Ho, J. S. K.; Zhang, X. P.; Lin, S. “Electrochemical Diazidation of Alkenes Catalyzed by Manganese Porphyrin Complexes with Second-Sphere Hydrogen-Bond Donors.” ACS Catal. 2022, 12, 14106–14112. DOI: 10.1021/acscatal.2c05186
Wu, X.; Gannett, C. N.; Liu, J.; Zeng, R.; Novaes, L. F. T.; Wang, H.; Abruña, H. D.; Lin, S. “Intercepting Hydrogen Evolution with Hydrogen-Atom Transfer: Electron-Initiated Hydrofunctionalization of Alkenes.” J. Am. Chem. Soc. 2022, 144, 17783–17791. DOI: 10.1021/jacs.2c08278
Wu, X.; Chang, Y.; Lin, S. “Titanium Radical Redox Catalysis Reactions, and Modes of Activation.” Chem 2022, 8, 1805–1821. DOI: 10.1016/j.chempr.2022.06.005 [html] Invited perspective. Dedicated to the occasion of Prof. John McMurry’s 80th birthday
Guo, S.; Kim, M. J.; Siu, J. C.; von Windheim, N.; Gall, K.; Lin, S.; Benjamin, J. W. “Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode.” ACS Sustainable Chemistry & Engineering 2022, 10, 7648–7657. DOI: 10.1021/acssuschemeng.2c01525
Martinez Alvarado, J. I.; Meinhardt, J. M.; Lin, S. “Working at the Interfaces of Data Science and Synthetic Electrochemistry.” Tetrahedron Chem 2022, 1, 100012. DOI: 10.1016/j.tchem.2022.100012
Zhang, W.; Lu, L.; Zhang, W.; Wang, Y.; Ware, S.; Mondragon, J.; Rein, J.; Strotman, N.; Lehnherr, D.; See, K.; Lin, S. “Electrochemically Driven Cross-Electrophile Coupling of Alkyl Halides.” Nature 2022, 604, 292–297. DOI: 10.1038/s41586-022-04540-4
Novaes, L. F. T.; Ho, J. S. K.; Mao, K.; Liu, K.; Tanwar, M.; Neurock, M.; Villemure, E.; Terrett, J. A.; Lin, S. “Exploring Electrochemical C(sp3)–H Oxidation for the Late-Stage Methylation of Complex Molecules.” J. Am. Chem. Soc. 2022, 144, 1187–1197. DOI: 10.1021/jacs.1c09412
Park, S. H.; Ju, M.; Ressler, A. J.; Shim, J.; Kim, H.; Lin, S. “Reductive Electrosynthesis: A New Dawn.” Aldrichimica Acta 2021, 54, 17–27. ISSN: 0002-5100
Rein, J.; Meinhardt, J. M.; Hofstra Wahlman, J. L.; Sigman, M. S.; Lin, S. “An Explosophore-Based Approach Towards the Prediction of Energetic Material Sensitivity Properties.” ChemRxiv pre-print 2021. DOI: 10.33774/chemrxiv-2021-16f6w
Wood, D. P.; Guan, W.; Lin, S. “Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides.” Synthesis 2021, 53, 4213–4220. DOI: 10.1055/s-0037-1610779
Rein, J.; Annand, J. R.; Wismer, M. K.; Fu, J.; Siu, J. C.; Klapars, A; Strotman, N. A.; Kalyani, D.; Lehnherr, D.; Lin, S. “Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor.” ACS Cent. Sci. 2021, 8, 1347–1355. DOI: 10.1021/acscentsci.1c00328
Novaes, L. F. T.; Liu, J.; Shen, Y.; Lu, L.; Meinhardt, J. M.; Lin, S. “Electrocatalysis as an Enabling Technology for Organic Synthesis.” Chem. Soc. Rev. 2021, 50, 7941–8002. DOI: 10.1039/D1CS00223F
Nelson, H.; Siu. J.C.; Saha, A.; Cascio, D.; Wu, S-B.; Lu, C.; Rodriguez, J. A.; Houk, K. N.; Lin, S. “Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO–N3 Charge-Transfer Complex.” Org. Lett. 2021, 23, 454–458. DOI: 10.1021/acs.orglett.0c03966
Lu, L.; Siu, J. C.; Lai, Y.; Lin, S. “An Electroreductive Approach to Radical Silylation via the Activation of Strong Si–Cl Bonds.” J. Am. Chem. Soc. 2020, 142, 21272–21278. DOI: 10.1021/jacs.0c10899
Zhang, W.; Lin, S. “Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism.” J. Am. Chem. Soc. 2020, 142, 20661–20670. DOI: 10.1021/jacs.0c08532
Robinson, S. G.; Wu, X.; Jiang, B.; Sigman, M. S.; Lin, S. “Mechanistic Studies Inform Design of Improved Ti(salen) Catalysts for Enantioselective [3+2] Cycloaddition.” J. Am. Chem. Soc. 2020, 142, 18471–18482. DOI: 10.1021/jacs.0c07128
Liu, J.; Lu, L.; Wood, D.; Lin, S. “New Redox Strategies in Organic Synthesis by Means of Electrochemistry and Photochemistry.” ACS Cent. Sci. 2020, 6, 1317–1340. DOI: 10.1021/acscentsci.0c00549
Song, L.; Fu, N.; Ernst, B. G.; Lee, W. H.; Frederick, M. O.; DiStasio, R. A. Jr.*; Lin, S.* “Dual Electrocatalysis Enables Enantioselective Hydrocyanation of Conjugated Alkenes.” Nat. Chem. 2020, 12, 747–754. DOI: 10.1038/s41557-020-0469-5 [open full-text access]
Siu, J. C.; Fu, N.; Lin, S.* “Catalyzing Electrosynthesis: A Homogeneous Electrocatalytic Approach to Reaction Discovery.” Acc. Chem. Res. 2020, 53, 547–560. DOI: 10.1021/acs.accounts.9b00529
Novaes, L. F. T.; Lin, S.* “Electrocatalytic Diazidation of Alkenes.” Trends in Chem. 2020, 2, 84–85. DOI: 10.1016/j.trechm.2019.10.005
Zhang, W.; Carpenter, K.; Lin, S.* “Electrochemistry Broadens the Scope of Flavin Photocatalysis: Photoelectrocatalytic Oxidation of Unactivated Alcohols.” Angew. Chem., Int. Ed. 2020, 59, 409–417. DOI: 10.1002/ange.201910300
Kim, H.; Kim, H.; Lambert, T.*; Lin, S.* “Reductive Electrophotocatalysis: Merging Electricity and Light to Achieve Extreme Reduction Potentials.” J. Am. Chem. Soc. 2020, 142, 2087–2092. DOI: 10.1021/jacs.9b10678 For the ChemRxiv preprint version, see
McCallum, T.; Wu, X.; Lin, S.* “Recent Advances in Titanium Radical Redox Catalysis.” J. Org. Chem. 2019, 84, 14369–14380. DOI: 10.1021/acs.joc.9b02465
Fu, N.; Song, L.; Liu, J.; Shen, Y.; Siu, J. C.; Lin, S.* “New Bisoxazoline Ligands Enable Enantioselective Electrocatalytic Cyanofunctionalization of Vinylarenes.” J. Am. Chem. Soc. 2019, 141, 14480–14485. DOI: 10.1021/jacs.9b03296
Lu, L.; Fu, N.; Lin, S.* “Three-Component Chlorophosphinoylation of Alkenes via Anodically Coupled Electrolysis.” Syn. Lett. 2019, 30, 1199–1203. DOI: 10.1055/s-0039-1689934
Ye, K-Y.; McCallum, T.; Lin, S.* “Bimetallic Radical Redox-Relay Catalysis for the Isomerization of Epoxides to Allylic Alcohols.” J. Am. Chem. Soc. 2019, 141, 9548–9554. DOI: 10.1021/jacs.9b04993
Siu, J. C.; Parry, J. B.; Lin, S.* “Aminoxyl-Catalyzed Electrochemical Diazidation of Alkenes Mediated by a Metastable Charge-Transfer Complex.” J. Am. Chem. Soc. 2019, 141, 2825–2831. DOI: 10.1021/jacs.8b13192
Fu, N.; Shen, Y.; Allen, A.R.; Song, L.; Ozaki, A.; Lin, S.* “Mn-catalyzed Electrochemical Chloroalkylation of Alkenes.” ACS Catal. 2019, 9, 746–754. DOI: 10.1021/acscatal.8b03209
Wu, X.; Hao, W.; Ye, K-Y.; Jiang, B.; Pombar, G.; Song, Z.; Lin, S.* “Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors.” J. Am. Chem. Soc. 2018, 140, 14836–14843. DOI: 10.1021/jacs.8b08605
Siu, J. C.; Sauer, G. S.; Saha, A.; Macey, R. L.; Fu, N.; Chauvirie, T.; Lancaster, K. M.*; Lin, S.* “Electrochemical Azidooxygenation of Alkenes Mediated by a TEMPO–N3Charge-Transfer Complex.” J. Am. Chem. Soc. 2018, 40, 12511–12520. DOI: 10.1021/jacs.8b06744
Fu, N.; Sauer, G. S.; Lin, S.* “A general, electrocatalytic approach to the synthesis of vicinal diamines.” Nat. Protoc. 2018, 13, 1725–1743. DOI: 10.1038/s41596-018-0010-0 [PDF][HTML]
Ye, K-Y.; Song, Z.; Sauer, G. S.; Harenberg, J. H.; Fu, N.; Lin, S.* “Synthesis of Chlorotrifluoromethylated Pyrrolidines by Electrocatalytic Radical Ene‐Yne Cyclization.” Chem. Eur. J. 2018, 24, 12274–12279. DOI:10.1002/chem.201802167 (Young Chemists Special Issue).
Sauer, G. S.; Lin, S.* “An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes.” ACS Catal. 2018, 8, 5175–5187. DOI: 10.1021/acscatal.8b01069 (Invited Perspective).
Hao, W.; Harenberg, J. H.; Wu, X.; Macmillan, S. N.; Lin, S.* “Diastereo- and Enantioselective Formal [3 + 2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.” J. Am. Chem. Soc. 2018, 140, 3514–3517. DOI: 10.1021/jacs.7b13710
Ye, K.; Pombar, G.; Fu, N.; Sauer, G. S.; Keresztes, I.; Lin, S.* “Anodically Coupled Electrolysis for the Heterodifunctionalization of Alkenes.” J. Am. Chem. Soc. 2018, 140, 2438–2441. DOI: 10.1021/jacs.7b13387
Peterson, B. M.; Lin, S.*; Fors, B. P.* “Electrochemically Controlled Cationic Polymerization of Vinyl Ethers.” J. Am. Chem. Soc. 2018, 140, 2076–2079. DOI: 10.1021/jacs.8b00173
Parry, J. B .; Fu, N.; Lin, S.* “Electrocatalytic Difunctionalization of Olefins as a General Approach to the Synthesis of Vicinal Diamines.” Synlett 2018, 29, 257–265. DOI: 10.1055/s-0036-1591749 (Invited Account).
Fu, N.; Sauer, G. S.; Lin, S.* “Electrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources.” J. Am. Chem. Soc. 2017, 139, 15548–15553. DOI: 10.1021/jacs.7b09388.
Hao, W.; Wu, X.; Sun, J. Z.; Siu, J. C.; MacMillan, S. N.; Lin, S.* “Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes.” J. Am. Chem. Soc. 2017, 139, 12141–12144. DOI: 10.1021/jacs.7b06723.
Fu, N.; Sauer, G. S.; Saha, A.; Loo, A; Lin, S.* “Metal-catalyzed electrochemical diazidation of alkenes.” Science 2017, 357, 575–579.