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个人简介

雷新响,男,教授,中南民族大学本科,温州大学硕士,中国科学院成都生物所,药物化学,博士,从事药物分析,有机分析及生物分析研究工作15年。先后主持国家自然科学基金,浙江省自然科学基金等项目8项。于2010-2011年在耶鲁大学从事研究工作1年。目前已发表SCI文章30余篇,包括以通讯作者身份发表在JACS,Angewandte Chemie,《核酸研究》,Organic Letters,《欧洲化学》等著名期刊的论文,1篇论文被美国化学会(Highlighted by ACS Noteworthy Chemistry)进行了专栏介绍点评,被Cell, Chemical Reviews,JACS等期刊引用。多次应邀在国际、全国或地区学术研讨会上做核磁共振新技术在有机药物分子研究中的应用工作报告。2014年11月与德国科学院院士Griesinger, Christian教授合作共同组织的,由中德科学研究中心资助的“中德核磁共振新方法在有机化学中的应用及前沿研讨会”,成功召开,2014年以“有机分子的立体化学及手性的核磁共振新分析方法”获得了中国分析测试协会科学技术奖(CAIA)“三等奖”1项,现为《Natural Products and Bioprospecting》编委和《波谱学杂志》青年编委。 曾在温州大学任职,2016年1月起,在药学院开展工作

研究领域

主要致力于基于核磁共振波谱为核心技术的天然产物结构鉴定和多肽药物的筛选,包括复杂有机分子构型构象分析,手性药物分子的快速测定,药物中间体和成药杂质成分的剖析;以药物靶标的核磁共振多肽药物筛选

近期论文

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Si-Yong Qin; Yan Jiang; Han Sun; Han Liu; Ai-Qing Zhang; Xinxiang Lei, Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems using a Liquid Crystalline based Medium, Angewandte Chemie International Edition, 2020, DOI: 10.1002/anie.202007243 Gaowei Li, Minshan Ma, Guifang Wang, Xiaojuan Wang, Xinxiang Lei, Efficient Enantiodifferentiation of Carboxylic Acids Using BINOL-Based Amino Alcohol as a Chiral NMR Solvating Agent. Frontiers in Chemistry, 2020, DOI: 10.3389/fchem.2020.00336 Xuemei Yin; Bin Chen; Feng Qiu; Xihong Wang; Yang Liao; Min Wang; Xinxiang Lei; Jian Liao , Enantioselective Palladium-Catalyzed Hydrofluorination of Alkenylarenes, ACS Catalysis, 2020, DOI: 10.1021/acscatal.9b05264 Xiao-Lu Li, Lu-Ping Chi, Armando Navarro-Vázquez, Songhwan Hwang, Peter Schmieder, Xiao-Ming Li, Xin Li, Sui-Qun Yang, Xinxiang Lei, Bin-Gui Wang, Han Sun, Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. Journal of the American Chemical Society, 2020, DOI: 10.1021/jacs.9b10961 Wen-Bo Han, Guang-Yi Wang, Jiang-Jiang Tang, Wen-Ji Wang, Han Liu, Roberto R Gil, Armando Navarro-Vázquez, Xinxiang Lei, Jin-Ming Gao, Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species. Organic Letters, 2019, DOI: 10.1021/acs.orglett.9b04099 Xiao-Yang Han, Yi-Xuan Xie, Chao-Qun Wu, Hong-Lian Ai, Xin-Xiang Lei, Xiang-Jing Wang, Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01. Chemistry & biodiversity, 2019, DOI: 10.1002/cbdv.201900471 Wen-Xuan Wang, Xinxiang Lei, Yan-Ling Yang, Zheng-Hui Li, Hong-Lian Ai, Jing Li, Tao Feng, Ji-Kai Liu, Xylarichalasin A, a Halogenated Hexacyclic Cytochalasan from the Fungus Xylaria cf. curta. Organic Letters, 2019, DOI: 10.1021/acs.orglett.9b02552 Cui-Ping Liu, Cheng-Ying Xie, Jin-Xin Zhao, Kai-Long Ji, Xin-Xiang Lei, Han Sun, Li-Guang Lou, Jian-Min Yue, Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells. Journal of the American Chemical Society, 2019, DOI: 10.1021/jacs.9b02259 Min Yang, Xiao-Lu Li, Jian-Rong Wang, Xinxiang Lei, Wei Tang, Xu-Wen Li, Han Sun, Yue-Wei Guo, Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.02,16]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis. The Journal of Organic Chemistry, 2019, DOI: 10.1021/acs.joc.8b03020 Wen-Xuan Wang, Xinxiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng, Tao Feng, Ji-Kai Liu, Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans, Organic Letters, 2019, DOI:10.1021/acs.orglett.9b00015 Han Liu, Pian Chen, Xiao-Lu Li, Han Sun, Xinxiang Lei, Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules. Magnetic Resonance in Chemistry, 2019, DOI: 10.1002/mrc.4825 Liwen Bai, Pian Chen, Jiangxia Xiang, Jiarui Sun, Xinxiang Lei, Enantiomeric NMR discrimination of carboxylic acids using actinomycin D as a chiral solvating agent, Organic & Biomolecular Chemistry, 2019, DOI: 10.1039/c8ob03012j Si-Yong Qin, Wen-Qiang Ding, Zhi-Wei Jiang, Xinxiang Lei, Ai-Qing Zhang, Directing an oligopeptide amphiphile into an aligned nanofiber matrix for elucidating molecular structures, Chemical Communications, 2019, DOI: 10.1039/c8cc09548e Feng Qiu, Han Liu, Huan Duan, Pian Chen, Shao-Juan Lu, Guang-Zhong Yang, Xin-Xiang Lei, Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill. Molecules, 2018, DOI: 10.3390/molecules23071624 Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei, Residual Dipolar Couplings in Structure Determination of Natural Products. Natural Products and Bioprospecting, 2018, DOI: 10.1007/s13659-018-0174-x Xinxiang Lei*, Feng Qiu, Han Sun, Liwen Bai, Wen-Xuan Wang, Wensheng Xiang and Hongping Xiao. A Self-assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurements of Residual Dipolar Couplings in Methanol Angewandte Chemie International Edition2017, 56, 12857-12861. Gao-Wei Li, Jiang-Ming Cao, Wen Zong, Li Hu, Mao-Lin Hu, Xinxiang Lei,*Han Sun,* Ren Xiang Tan*. Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Chemistry European Journal A 2017, 23, 7653-7656. José A. A. França, Armando Navarro-Vázquez, Xinxiang Lei, Han Sun, Christian Griesingere and Fernando Hallwassb.Complete NMR assignment and conformational analysis of 17-α-ethinylestradiol by using RDCs obtained in grafted graphene oxide Magn. Reson. Chem. 2017, 55, 297- 303. Gao Wei, Li Xinxiang Lei*.Structural elucidation of organic molecule from residual dipolar Couplings. SCIENTIA SINICA Chimica,2017, 47, 1401-1423. Gaowei Li, Jiangming Cao, Wen Zong, Xinxiang Lei*, Renxiang Tan* Enantiodiscrimination of carboxylic acids using the diphenylprolinol NMR chiral solvating agents, Org. Chem. Front.2016, 3, 96-102. Wen Zong, Gao-Wei Li, Jiang-Ming Cao, Xinxiang Lei,* Mao-Lin Hu, Han Sun,*Christian Griesinger, Ren Xiang Tan*. Liquid Crystals from Polymer Grafted Graphene Oxide as Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO”, Angewandte Chemie International Edition,2016, 55, 3690-3693. Jun-Jun Ge, Ling-Tian Wang, Pian Chen, Yan Zhang, Xin-Xiang Lei*, Xiao-Xia Ye*.Two new tetracyclic triterpenoids from the barks of Melia azedarach , J. Asian Nat. Prod.Res. 2015, 18, 20-25. Xinxiang Lei,* Zhen Xu, Han Sun, Shun Wang, Christian Griesinger, Li Peng, Chao Gao,*Ren X. Tan*. Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents”, J. Am. Chem. Soc.2014, 136, 11280−112832. Qingzhu Ma, Minshan Ma, Hongying Tian, Xiaoxia Ye, Hongping Xiao, Lian-hui Chen,*, Xinxiang Lei*. A Novel Amine Receptor Based on the Binol Scaff old Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids”, Organic Letters, 2012, 14: 5813-5815. Xin-Xiang Lei, Jie Xu, Wei Ma, Chong Qiao, Martin A. Newman,Scott M. Hammond, Yingqun Huang,* Determinants of mRNA recognition and translation regulation by Lin28,Nucl. Acids Res.2012, 40, 5174-5184.

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