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研究领域

Analytical Chemistry

Focused Research Interests: • Laser Desorption Postionization for Mass Spectrometric Imaging is used to probe bacterial biofilms and other complex molecular surfaces. We combine vacuum ultraviolet postionization and chemical derivatization for the selective ionization of small molecule analytes in complex mixtures. C60 ion beams are also used to depth profile these materials. Laser desorption postionization is compared with established methods of imaging mass spectrometry such as matrix-assisted laser desorption ionization and cluster secondary ion mass spectrometry. • Bacterial Biofilms and the Biofilm-Biomaterial Interface. We are using mass spectrometric imaging and related strategies for the analysis of quorum sensing species and antibiotics in bacterial biofilms. One of the goals of this work is to probe antibiotic resistance mechanisms in biofilms. We are also examining the role of bacterial biofilms in the degradation of dental composites within the oral cavity. We are working on developing new biomaterials that inhibit the growth of bacterial biofilm, in conjunction with the work described above. For example, we are studying methods to improve the ability of dental composites to resist the biofilm formation that leads to caries and contributes to composite failure under mechanical strain. • Growing Nanocomposite Materials by Cluster Beam & Ion-Assisted Deposition. Gaseous ions and neutrals such as acetylene ions or semiconductor clusters are used as molecular building blocks for the gaseous deposition of nanostructured composite thin films from the atomic level upwards. Lead sulfide nanocrystal-organic oligomer films are prepared by this method for use in nonlinear optical devices and third generation photovoltaics. We also prepare similar materials by the traditional colloidal methods, for comparison with those prepared by these gaseous deposition methods. • Applying Advanced Surface Analysis Methods. We have applied many other methods in advanced surface analysis to the above problems. These methods include X-ray and ultraviolet photoelectron spectroscopy, near edge X-ray absorption spectroscopy, X-ray surface scattering, secondary ion mass spectrometry, transmission and scanning electron microscopy, transmission and reflection infrared spectroscopy, linear and nonlinear optical absorption of films, quartz crystal microbalance measurement of film deposition or removal, and X-ray diffraction.

近期论文

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"High lateral resolution vs. molecular preservation in near-IR fs-laser desorption postionization mass spectrometry" Y. Cui, I.V. Veryovkin, M.W. Majeski, D.R. Cavazos, and L. Hanley, Anal. Chem. (2014) ASAP. http://dx.doi.org/10.1021/ac5041154 M.W. Majeski, I.L. Bolotin, and L. Hanley, “Cluster beam deposition of Cu2-XS nanoparticles into organic thin films”, ACS Appl. Mater. Interf. (2014) Majeski ACSAMI (2014) ASAP. http://dx.doi.org/10.1021/am5028428 “Internal energy of thermometer ions formed by femtosecond laser desorption: Implications for mass spectrometric imaging”, S. Milasinovic, Y. Cui, R.J. Gordon and L. Hanley, J. Phys. Chem. C (2014) ASAP. http://dx.doi.org/10.1021/jp504062u “Ion sources for mass spectrometric identification and imaging of molecular species”, C. Bhardwaj and L. Hanley, Nat. Prod. Rep. 31 (2014) 756-767. http://dx.doi.org/10.1039/C3NP70094A “Differentiation of microbial species and strains in coculture biofilms by multivariate analysis of laser desorption postionization mass spectra”, C. Bhardwaj, Y. Cui, T. Hofstetter, S.Y. Liu, H.C. Bernstein, R.P. Carlson, M. Ahmed, and L. Hanley, Analyst 138 (2013) 6844-6851. http://dx.doi.org/10.1039/C3AN01389H, PMCID: 24067765 “Molecular imaging and depth profiling of biomaterials interfaces by femtosecond laser desorption postionization mass spectrometry, Y. Cui, C. Bhardwaj, S. Milasinovic, R.P. Carlson, R.J. Gordon, and L. Hanley, ACS Appl. Mater. Interf. 5 (2013) 9269-9275. http://dx.doi.org/10.1021/am4020633 “Quantification of antibiotic in biofilm-inhibiting multilayers by 7.87 eV laser desorption postionization MS imaging”, M. Blaze M. T., A. Akhmetov, B. Aydin, P.D. Edirisinghe, G. Uygur, and L. Hanley, Anal. Chem. 84 (2012) 9410-9415. http://dx.doi.org/10.1021/ac302230e, PMCID: 3491138. “Laser desorption VUV postionization MS imaging of a cocultured biofilm”, by C. Bhardwaj, J.F. Moore, Y. Cui, G.L. Gasper, H.C. Bernstein, R.P. Carlson, and L. Hanley, Anal. Bioanal. Chem. 405 (2013) 6969-6977. http://dx.doi.org/10.1007/s00216-012-6454-0, PMCID: PMC3566334. “Acetylene ion-enhanced bonding of PbS nanoparticles to quaterthiophene in thin films”, by F.D. Pleticha, D. Lee, S.B. Sinnott, I.L. Bolotin, M.W. Majeski, and L. Hanley, J. Phys. Chem. C 116 (2012) 21693-21698. http://dx.doi.org/10.1021/jp306668k “Depth profiling and imaging capabilities of an ultrashort pulse laser ablation time of flight mass spectrometer”, Y. Cui, J.F. Moore, S. Milasinovic, Y. Liu, R.J. Gordon, and L. Hanley, Rev. Sci. Instrum. 83 (2012) 093702. http://dx.doi.org/10.1063/1.4750974, PMCID: PMC3461015 “Identification and imaging of peptides and proteins on Enterococcus faecalis biofilms by matrix assisted laser desorption ionization mass spectrometry”, M. Blaze M. T., B. Aydin, R. Carlson, and L. Hanley, Analyst 137 (2012) 5018-5025. http://dx.doi.org/10.1039/C2AN35922G, PMCID: PMC3654527. “Photoresponse of PbS nanoparticle - quaterthiophene films prepared by gaseous deposition as probed by XPS,” M.W. Majeski, F.D. Pleticha, I.L. Bolotin, L. Hanley, E. Yilmaz and S. Suzer, J. Vac. Sci. Technol. 30 (2012) 04D109. http://dx.doi.org/10.1116/1.4709386 “Feasibility of depth profiling of animal tissue by ultrashort pulse laser ablation,” S. Milasinovic, Y. Liu, C. Bhardwaj, M. Blaze M.T., R.J. Gordon and L. Hanley, Anal. Chem. 84 (2012) 3945-3951. http://dx.doi.org/10.1021/ac300557a, NIHSMID 371169 “Synthesis of PbS nanocrystal/functionalized conducting polymers for plastic solar cells”, M. Zhou, B. Wang, X. Jiang, A.A. Zakhidov, J.P. Ferraris, D. A(s)unskis, and L. Hanley, Inter. J. Nanosci. 10 (2011) 521-532. “Brominated tyrosine and polyelectrolyte multilayer analysis by laser desorption VUV postionization and secondary ion mass spectrometry”, M. Blaze M.T., L.K. Takahashi, J. Zhou, M. Ahmed, G.L. Gasper, F.D. Pleticha, and L. Hanley, Anal. Chem. 83 (2011) 4962-4969 http://pubs.acs.org/doi/abs/10.1021/ac200693h, PMCID: PMC3115520 “Comparing vacuum and extreme ultraviolet radiation for postionization of laser desorbed neutrals from bacterial biofilms and organic fullerenes”, G.L. Gasper, L.K. Takahashi, J. Zhou, M. Ahmed, J.F. Moore, and L. Hanley, Nucl. Instrum. Meth. Phys. Res. A 649 (2010) 222-224 (Proc. of 16th Pan-American Synchrotron Radiation Instrumentation Conference, Argonne National Laboratory). http://dx.doi.org/10.1016/j.nima.2010.12.024, PMCID: PMC3150573 “Laser desorption postionization mass spectrometry of antibiotic-treated bacterial biofilms using tunable vacuum ultraviolet radiation”, G.L. Gasper, L.K. Takahashi, J. Zhou, M. Ahmed, J.F. Moore, and L. Hanley, Anal. Chem. 82 (2010) 7472-7478. DOI: http://dx.doi.org/10.1021/ac101667q, PMCID: PMC2932786 “Effects of surface chemistry on nonlinear absorption, scattering, and refraction of PbSe and PbS nanocrystals”, I.L. Bolotin, D.J. Asunskis, A.M. Jawaid, Y. Liu, P.T. Snee, and L. Hanley, J. Phys. Chem. C 114 (2010) 16257-16262. DOI: http://dx.doi.org/10.1021/jp105069k “Ultrashort pulse laser ablation for depth profiling of bacterial biofilms”, S. Milasinovic, Y. Liu, G.L. Gasper, Y. Zhao, J.L. Johnston, R.J. Gordon and L. Hanley, J. Vac. Sci. Technol. A. 28 (2010) 647-651. http://dx.doi.org/10.1116/1.3397736. PMCID: PMC2963088 “Handheld directed energy sensor for clinician safety and environmental monitoring”, M.D. Colvard, M. Naiman, L. Danziger, and L. Hanley, Aviat. Space Environ. Med. 81:6 (2010) 602-604. DOI: http://dx.doi.org/10.3357/ASEM.2652.2010 “Antibacterial activity of dental composites containing zinc oxide nanoparticles”, B. Aydin Sevinc and L. Hanley, J. Biomed. Mater. Res. B, in press (1/12/10). “Laser desorption postionization for imaging MS of biological material”, A. Akhmetov, J.F. Moore, G.L. Gasper, P.J. Koin, and L. Hanley, J. Mass Spectrom. 45 (2010) 137-145 “Cluster beam deposition of metal, insulator, and semiconductor nanoparticles”, A.M. Zachary, I.L. Bolotin, and L. Hanley, chap. in “Nanofabrication using Focused Ion and Electron Beams: Principles and Applications”, S. Moshkalev, ed. (Oxford University Press, 2010), in press. “Effects of Surface Chemistry on Nonlinear Absorption of PbS Nanocrystals”, D.J. Asunskis, I.L. Bolotin, J.E. Haley, A. Urbas, and L. Hanley”, J. Phys. Chem. 113(46) (2009) 19824-19829 “Cluster beam deposition of lead sulfide nanocrystals into organic matrices”, A.M. Zachary, I. Bolotin, D.J. Asunskis, A.T. Wroble, and L. Hanley, Applied Materials & Interfaces. 1(8) (2009) 1770-1777 “Light and Molecular Ions: The Emergence of Vacuum Ultraviolet Single Photon Ionization in Mass Spectrometry”, L. Hanley and R. Zimmermann, Anal. Chem. 81 (2009) 4174–4182. DOI URL: http://dx.doi.org/10.1021/ac8013675 “Nonlinear optical properties of PbS nanocrystals grown in polymer solutions”, D.J. Asunskis, I.L. Bolotin, and L. Hanley, J. Phys. Chem. C 112 (2008) 9555-9558. DOI URL: http://dx.doi.org/10.1021/jp8037076

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