Crawford, B. D. - University of New Brunswick

研究领域

Tissues are comprised of a population of cells embedded in a complex matrix of large glycoproteins that contribute significantly to both the mechanical and biological properties of the tissue. During embryonic development, and physiological as well as pathological tissue remodeling in adults, cells secrete proteases that degrade this extracellular matrix, allowing them to re-synthesize it in a new configuration. The regulation of this degradation and re-synthesis is of fundamental importance not only during embryonic development, but also the homeostasis of normal adult tissues, and its mis-regulation underlies a plethora of pathologies. Research in my lab utilizes the zebrafish embryo as a model system in which we can manipulate the molecules responsible for these activities and observe their activities using novel techniques such as in vivo zymography, as well as well-established molecular and cell-biological approaches.

近期论文

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Sariahmetoglu, M., Crawford, B.D., Leon, H., Sawicka, J., Li, L., Ballermann, B.J., Holmes, C., Berthiaume, L.G., Holt, A., Sawicki, G., and Schulz, R. (2007). Matrix metalloprotease-2 is regulated by phosphorylation. Accepted for publication in FASEB Journal, January 23, 2007. Chow, A.K., Cena, J., El-Yazbi, A.F., Crawford, B.D., Holt, A., Cho, W.J., Daniel, E.E., and Schulz, R. (2007). Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. Accepted for publication in the Journal of Molecular and Cellular Cardiology, January 23, 2007. Wohlgemuth, S.L., Crawford, B.D., and Pilgrim, D.B. (2007). The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. Developmental Biology 303:483-492. Crawford, B.D. and Pilgrim, D.B. (2005). Ontogeny and Regulation of MMP activity in the Zebrafish Embryo by in vitro and in vivo Zymography. Developmental Biology 286:405-414. Manning, A.G., Crawford, B.D., Waskiewicz, A.J. and Pilgrim, D.P. (2004). An unc-119 homologue required for normal development of the zebrafish nervous system. Genesis 40:223–230. Crawford, B. D., Henry, C. A., Clason, T., Becker, A. L. and Hille, M. B. (2003). Activity and Distribution of Paxillin, FAK, and Cadherin Indicate Cooperative Roles during Zebrafish Morphogenesis. Molecular Biology of the Cell 14(8):3065-81. Henry, C. A., Crawford, B. D., Yan, Y-L., Postlethwait, J., Cooper, M. S., and Hille, M. B. (2001). Roles for Zebrafish Focal Adhesion Kinase in Notochord and Somite Morphogenesis. Developmental Biology 240:474–487