Pansare, Sunil V. - Memorial University of Newfoundland

研究领域

Our research interests are mainly in the area of asymmetric organic synthesis. We have developed organocatalytic variants of conjugate addition reactions and vinylogous aldol reactions, and we have applied our methodology in the total synthesis of a variety of alkaloids. We have also utilized ephedrine as a chiral controller in the asymmetric synthesis of alpha hydroxy acids and applied this methodology in the synthesis of alkaloids and marine natural products. Other synthetic methodologies developed in our group include new applications of sulfamide in the synthesis of vicinal diamines and related heterocycles and the hetero atom-H bond insertion reactions of diazocarbonyl compounds. We have identified scandium triflate as a promising catalyst for the insertion reactions. Recent research in our group focuses on the design of new organocatalysts for fundamental, carbon-carbon bond forming reactions. We are also interested in the development of new multicomponent reactions for combinatorial chemistry based applications in diversity-oriented synthesis.

近期论文

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Manchoju, A.; Pansare, S. V. Catalytic Undirected Intermolecular C−H Functionalization of Arenes with 3‑Diazofuran-2,4-dione: Synthesis of 3‑Aryl Tetronic Acids, Vulpinic Acid, Pinastric Acid, and Methyl Isoxerocomate Org. Lett. 2016, 18, 5952. Gopinathan, M.; Pansare, S. V. Modular Synthesis of Allyl Vinyl Ethers for the Enantioselective Construction of Functionalized Quaternary Stereocenters RSC Adv. 2016, 6, 104556. Moorthy, N. V. G.; Dyapa, R.; Pansare, S. V. Formal Synthesis of (+)-Lasubine II and (-)-Subcosine II via Organocatalytic Michael Addition of a Ketone to an alpha-Nitrostyrene Org. Lett. 2015, 17, 5312. Manchoju, A.; Thorat, R. G.; Pansare, S. V. Enantioselective Synthesis of Functionalized Quaternary Stereocenters Eur. J. Org. Chem. 2015, 5939. Pansare, S. V.; Thorat, R. G. Recent Advances in the Synthesis of Selected Indolizidine and Quinolizidine Alkaloids Targets in Heterocyclic Systems 2013, 17, 57. Thorat, R. G.; Pansare, S. V. A General Approach to 1-Hydroxymethylquinolizidine and 8-Hydroxymethylindolizidine Stereoisomers: Synthesis of (+)-Epitashiromine and Formal Syntheses of (+)-Epilupinine and (+)-Tashiromine Eur. J. Org. Chem. 2013, 7282. Pansare, S. V.; Kulkarni, K. G. An enantioselective approach to (-)-aphanorphine featuring a stereoselective oxidative amidation RSC Advances 2013, 3, 19127. Pansare, S. V.; Paul, E. K. Synthesis of Synthesis of (+)-Febrifugine and a Formal Synthesis of (+)-Halofuginone Employing an Organocatalytic Direct Vinylogous Aldol Reaction Synthesis 2013, 45, 1863. (Special issue in honor of Professor Scott Denmark) (Featured on the Organic Chemistry portal (www.organic-chemistry.org/Highlights/2014/12May.shtm) Pansare, S. V.; Dyapa, R. Enantioselective Approach to Functionalized Quinolizidines: Synthesis of (+)-Julandine and (+)-Cryptopleurine Org. Biomol. Chem. 2012, 10, 6776. Pansare, S. V.; Paul, E. K. Synthesis of (+)-L-733,060, (+)-CP-99,994 and (2S,3R)-3-Hydroxypipecolic acid: Application of an Organocatalytic direct vinylogous aldol reaction Org. Biomol. Chem. 2012, 10, 2119. Pansare, S. V.; Paul, E. K. The Organocatalytic Vinylogous Aldol Reaction: Recent Advances Chem. Eur. J. 2011, 17, 8770. Pansare, S. V.; Lingampally, R.; Dyapa, R. A Simple Enantioselective Route to Functionalized Indolizidines: Synthesis of (+)-Ipalbidine and (+)-Antofine Eur. J. Org. Chem. 2011, 2235. Pansare, S. V.; Paul, E. K. Organocatalytic Asymmetric Direct Vinylogous Aldol Reactions of g-Crotonolactone with Aromatic Aldehydes Chem. Commun. 2011, 47, 1027. Pansare, S. V.; Adsool, S. V.; Dyapa, R. Enantioselective Synthesis of (S) - Homocitric Acid Lactone and (R) - Per Homocitric Acid Lactone Involving Organocatalysis Tetrahedron: Asymmetry 2010, 21, 771. Pansare, S. V.; Lingampally, R.; Kirby, R. L. Stereoselective Synthesis of 3-Aryloctahydroindoles and Application in a Formal Synthesis of (-)-Pancracine Org. Lett. 2010, 12, 556. Pansare, S. V.; Kirby, R. L. Secondary-Secondary Diamine Catalysts for the Enantioselective Michael Addition of Cyclic Ketones to Nitroalkenes Tetrahedron 2009, 65, 4557. Pansare, S. V.; Lingampally, R. Synthesis and Evaluation of Guanidinyl Pyrrolidines as Bifunctional Catalysts for Enantioselective Conjugate Additions to Cyclic Enones Org. Biomol. Chem. 2009, 7, 319. Adsool, V. A.; Pansare, S. V. An Enantioselective Approach to (+)-Laurencin Org. Biomol. Chem. 2008, 6, 2011. Pansare, S. V.; Adsool, V. A. Enantioselective Synthesis of (R)-Homocitric Acid Lactone Tetrahedron Lett. 2007, 48, 7099. Pansare, S. V.; Adsool, V. A. Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles Org. Lett. 2006, 8, 5897. Pansare, S. V.; Pandya, K. Simple Diamine- and Triamine-Protonic Acid Catalysts for the Enantioselective Michael Addition of Cyclic Ketones to Nitroalkenes J. Am. Chem. Soc. 2006, 128, 9624. Pansare, S. V.; Adsool, V. A. A Concise, Enantioselective Approach to (-)-Quinic Acid Org. Lett. 2006, 8, 2035.