Bignell, Dawn - Memorial University of Newfoundland

研究领域

(1) Characterization of virulence-associated secondary metabolites produced by the common scab pathogen Streptomyces scabies. (2) Characterization of Streptomyces spp. causing potato common scab disease in Newfoundland.

近期论文

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Bown, L. and Bignell, D.R.D. (2017) Purification of N-coronafacoyl phytotoxins from Streptomyces scabies. Bio-protocol 7(7): e2214. DOI: 10.21769/BioProtoc.2214 Zhang, Y., Bignell, D.R.D., Zuo, R., Fan, Q., Huguet-Tapia, J.C., Ding, Y. and Loria, R. (2016) Promiscuous pathogenicity islands and phylogeny of pathogenic Streptomyces spp. Molecular Plant-Microbe Interactions 29(8): 640-650. doi: 10.1094/MPMI-04-16-0068-R Bown, L.†, Altowairish, M.S.†, Fyans, J.K. and Bignell, D.R.D. (2016) Production of the Streptomyces scabies coronafacoyl phytotoxins involves a novel biosynthetic pathway with an F420-dependent oxidoreductase and a short-chain dehydrogenase/reductase. Molecular Microbiology 101(1): 122-135. doi: 10.1111/mmi.13378 († Co-first authors) Ferguson, N.L., Pena-Castillo, L., Moore, M.A., Bignell, D.R.D. and Tahlan, K. (2016) Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus. Journal of Industrial Microbiology and Biotechnology 43: 537-555. doi: 10.1007/s10295-016-1733-y Fyans, J.K.†, Bown, L.† and Bignell, D.R.D. (2016) Isolation and characterization of plant pathogenic Streptomyces species associated with common scab – infected potato tubers in Newfoundland. Phytopathology 106(2): 123-131. doi:10.1094/PHYTO-05-15-0125-R († Co-first authors) Cheng, Z., Bown, L., Tahlan. K. and Bignell, D.R.D. (2015) Regulation of coronafacoyl phytotoxin production by the PAS-LuxR family regulator CfaR in the common scab pathogen Streptomyces scabies. PLOS ONE 10(3): e0122450. doi:10.1371/journal.pone.0122450 Fyans, J.K., Altowairish, M.S., Li, Y. and Bignell, D.R.D. (2015) Characterization of the coronatine-like phytotoxins produced by the common scab pathogen Streptomyces scabies. Molecular Plant-Microbe Interactions 28(4): 443-454. doi:10.1094/MPMI-09-14-0255-R. Huguet-Tapia, J.C., Bignell, D.R.D. and Loria, R. (2014) Characterization of the integration and modular excision of the integrative conjugative element PAISt in Streptomyces turgidiscabies Car8. PLOS ONE 9(6): e99345. Bignell, D.R.D.†, Francis, I.M.†, Fyans, J.K. and Loria, R. (2014) Thaxtomin A production and virulence are controlled by several bld gene global regulators in Streptomyces scabies. Molecular Plant-Microbe Interactions 27(8): 875-885. († Co-first authors) Bignell, D.R.D., Fyans, J.K. and Cheng, Z. (2014) Phytotoxins produced by plant pathogenic Streptomyces species. Journal of Applied Microbiology 116: 223-235. Fyans, J.K., Bignell, D., Loria, R., Toth, I. and Palmer, T. (2013) The ESX/type VII secretion system modulates development, but not virulence, of the plant pathogen Streptomyces scabies. Molecular Plant Pathology 14: 119-130. Bignell, D.R.D., Huguet, J.C., Joshi, M.V., Pettis, G.S. and Loria, R. (2010) What does it take to be a plant pathogen: Genomic insights from Streptomyces species. Antonie van Leeuwenhoek 98: 179-194. Bignell, D.R.D., Seipke, R.F., Chambers, A., Parry, R.J. and Loria, R. (2009) Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions. Molecular Plant-Microbe Interactions 23: 161-175. Johnson, E.G.†, Krasnoff, S.B.†, Bignell, D.R.D.†, Chung, W.-C., Tao, T., Parry, R.J., Loria, R. and Gibson, D.M. (2009) 4-Nitrotryptophan is a substrate for the non-ribosomal peptide synthetase TxtB in the thaxtomin A biosynthetic pathway. Molecular Microbiology 73: 409-418. († Co-first authors) Parashar, A., Colvin, K.R., Bignell, D.R.D. and Leskiw, B.K. (2009) BldG and SCO3548 interact antagonistically to control key developmental processes in Streptomyces coelicolor. Journal of Bacteriology 191: 2541-2550. Loria, R., Bignell, D.R.D., Moll, S., Huguet-Tapia, J.C., Joshi, M.V., Johnson, E.G., Seipke, R.F. and Gibson, D.M. (2008). Thaxtomin biosynthesis: The path to plant pathogenicity in the genus Streptomyces. Antonie van Leeuwenhoek 94: 3-10. Joshi, M.V., Bignell, D.R.D., Johnson, E.J., Sparks, J.P., Gibson, D.M. and Loria, R. (2007). The AraC/XylS regulator TxtR modulates thaxtomin biosynthesis and virulence in Streptomyces scabies. Molecular Microbiology 66(3): 633-642.* * Evaluated by Steven Busby, Faculty of 1000 Biology, 15 Nov 2007 http://www.f1000biology.com/article/id/1094984 Bignell, D.R.D., Bate, N. and Cundliffe, E. (2007). Regulation of tylosin production: role of a TylP-interactive ligand. Molecular Microbiology 63(3): 838-847. Bate, N., Bignell, D.R.D. and Cundliffe, E. (2006). Regulation of tylosin biosynthesis involving ‘SARP-helper’ activity. Molecular Microbiology 62(1): 148-156. Bignell, D.R.D.†, Tahlan, K.†, Colvin, K.R., Jensen, S.E. and Leskiw, B.K. (2005). Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrobial Agents and Chemotherapy 49: 1529-1541. († Co-first authors) Bignell, D.R.D., Lau, L.H., Colvin, K.R. and Leskiw, B.K. (2003). The putative anti-anti-sigma factor BldG is post-translationally modified by phosphorylation in Streptomyces coelicolor.FEMS Microbiology Letters 225: 93-99. Bignell, D.R.D., Warawa, J.L., Strap, J.L., Chater, K.F., and Leskiw, B.K. (2000). Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation. Microbiology 146: 2161-2173.