个人简介

Dr. de Vries received his Ph.D. in Chemical Physics at the University of Amsterdam in 1980. After spending four years in our department at UCSB as a Research Associate, he became a Research Staff member at the IBM Almaden Research Laboratory. In 1997 Dr. de Vries became an Associate Professor in the Department of Chemistry, Hebrew University of Jerusalem. In September 2000, Dr. de Vries joined The UCSB Department of Chemistry and Biochemistry as a Professor of Physical Chemistry. While at IBM he won three awards for outstanding innovation and technical achievement. He was elected Humboldt Fellow (2003) and AAAS Fellow (2008).

研究领域

Physical Chemistry/Biochemistry & Biophysics/Biology-Inspired Chemistry & Physics/Structural Chemistry/Spectroscopy & Advanced Analysis

The de Vries lab combines a number of advanced physical chemistry techniques for a novel approach to the study of individual molecules. This leads to a combination of physical and analytical chemistry by employing laser induced desorption of molecules from surfaces, photoionization, multiphoton spectroscopy, femtosecond spectroscopy and mass spectrometry. Included are studies of complex molecules, isolated biomolecules and clusters, and surface analytical applications. There are two major directions to this research: (1) Gas phase techniques enable the study of isolated molecules, free of interactions. A major thrust is the laser spectroscopy of isolated biomolecular building blocks. These include single DNA bases and amino acids, as well as their clusters with each other and with water molecules. These studies touch on questions such as: “What is the chemical origin of life?”, What makes a peptide fold?”, or “How is the machinery of life protected from UV radiative damage?”. (2) The same techniques also apply to state of the art analytical applications, analyzing fragile organics by laser mass spectrometry. The de Vries lab applies Laser mass spectrometry to detect trace compounds for beverage residues in archeological artifacts or to study objects of cultural heritage.

近期论文

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Resonant Infrared Multiple Photon Dissociation Spectroscopy of Anionic Nucleotide Monophosphate Clusters, Marshall R. Ligare, Anouk M. Rijs, Giel Berden, Martin Kabelac, Dana Nachtigallova, Jos Oomens Mattanjah S. de Vries (submitted) Characterizing the dark state in thymine and uracil by double resonant spectroscopy and quantum computation M. Ligare, F. Siouri, Ota Bludsky, D. Nachtigallova, M.S. de Vries (submitted) Sub-Micron Proximal Probe Thermal Desorption and Laser Mass Spectrometry on Painting Cross-Sections Shawn C. Owens, Jacob A. Berenbeim, Catherine Schmidt Patterson, Eoghan P. Dillon and M.S. de Vries Analytical Methods 6 (22), 8940 – 8945 (2014) Gas-phase IR Spectroscopy of Nucleobases. in: Gas-phase IR Spectroscopy for the Structural Characterization of Biomolecules eds: A Rijs and J Oomens. Springer (in press, DOI: 10.1007/128_2014_577) UV-excitation from an experimental perspective I: frequency resolved . in: Photoinduced phenomena in nucleic acids Sringer. eds: Mario Barbatti, Antonio Borin and Susanne Ullrich (in press) . Excited State Dynamics of DNA Bases. Karl Kleinermanns, Dana Nachtigallová, and Mattanjah S. de Vries, International Reviews in Physical Chemistry, 32(2): 308-342 (2013) Tautomer-Selective Spectroscopy of Nucleobases, Isolated in the Gas Phase. Mattanjah S. de Vries. Chapter 7 in: Tautomerism: Methods and Theories, Wiley-VCH, ed: Liudmil Antonov. (2013); pp 177-196. Structure of 2,4-diaminopyrimidine – theobromine alternate base pairs Zsolt Gengeliczki, Michael P. Callahan, Martin Kabeláč, Anouk M. Rijs, and Mattanjah S. de Vries. J. Phys. Chem. A 115(41): 11423-11427 (2011). Isolated Gramicidin Peptides Probed by IR Spectroscopy Anouk M. Rijs, Martin Kabeláč, Ali Abo-Riziq, Pavel Hobza and Mattanjah S. de Vries. ChemPhysChem 12,1816-1821 (2011). Conformational Structure of Tyrosine, Tyrosyl-glycine, and 2 Tyrosyl-glycyl-glycine by Double Resonance Spectroscopy Ali Abo-Riziq, Louis Grace, Bridgit Crews, Michael P. Callahan, Tanja van Mourik, and Mattanjah S. de Vries J. Phys. Chem. A, 2011, 115 (23), pp 6077–6087 (2011). The effects of C5 substitution on the photochemistry of uracil Dana Nachtigallováa, Hans Lischka, Jaroslaw J. Szymczak, Mario Barbatti, Pavel Hobza, Zsolt Gengeliczki, Gustavo Pino, Michael P. Callahan, Mattanjah S. de Vries. Phys. Chem. Chem. Phys., 12, 4924-4933 (2010). Guanine-Aspartic Acid Interactions Probed with IR-UV Resonance Spectroscopy Bridgit O. Crews, Ali Abo-Riziq, Kristýna Pluhačková, Patrina Thompson, Glake Hill, Pavel Hobza, Mattanjah S. de Vries.Phys. Chem. Chem. Phys., 12, 3597-3604 (2010). Effect of substituents on the excited-state dynamics of the modified DNA bases 2,4-diaminopyrimidine and 2,6-diaminopurine Zsolt Gengeliczki, Michael P. Callaha‡, Nathan Svadlenak, Csaba István Pongor, Bálint Sztáray, Leo Meerts, Dana Nachtigallová†, Pavel Hobza, Mario Barbatti, Hans Lischka, Mattanjah S. de Vries, Phys. Chem. Chem. Phys.,12, 5375-5388 (2010). Experimental Observation of Guanine Tautomers with VUV Photoionization Jia Zhou, Oleg Kostko, Christophe Nicolas, Xiaonan Tang, Leonid Belau, Mattanjah S. de Vries, and Musahid Ahmed J. Phys. Chem. A, 113(17), 4829–4832 (2009). Potential energy and free energy surfaces of glycyl-phenyalanyl-alanine (GFA) tripeptide: experiment and theory Valdes, H.; Spiwok, V.; Rezac, J.; Reha, D.; Ali G. Abo-Riziq, de Vries, M.; Hobza, P. Chemistry-A European Journal, 14, 4886-4898 (2008) Isomer discrimination of polycyclic aromatic hydrocarbons in the Murchison meteorite by resonant ionization Michael P. Callahan, Ali Abo-Riziq, Bridgit Crews, Louis Grace, and Mattanjah S. de VriesSpectrochimica Acta Part A 71 , 1492-1495 (2008). Shaping of a Conformationally Flexible Molecular Structure for Spectroscopy Anouk M. Rijs, Mattanjah S. de Vries, Jeffrey S. Hannam, David A. Leigh, Marianna Fanti, Francesco Zerbetto, Wybren Jan Buma. Angewandte Chemie, International Edition, 47, 3174-3179 (2008) Chapter 12: Isolated DNA base pairs, interplay between theory and experiment Mattanjah S. de Vries in “Radiation Induced Molecular Phenomena in Nucleic Acid”, M.K. Shukla and J. Leszczynski (eds.) under the book series: “Challenges and Advances in Computational Chemistry and Physics,” Jerzy Leszczynski (ed.), 2008, Springer, Netherlands. (2008) Non-standard base pairing and stacked structures in methyl xanthine clusters Michael P. Callahan, Zsolt Gengeliczki, Nathan Svadlenak, Haydee Valdes, Pavel Hobza and Mattanjah S. de Vries, PCCP 10, 2819-2826 (2008) Resonant two-photon ionization mass spectrometry of phenolic acids and polyphenols Michael P. Callahan, Zsolt Gengeliczki, and Mattanjah S. de Vries. Analytical Chemistry 80, 2199-2033 (2008)