Speed, Alex - Dalhousie University - Department of Chemistry

研究领域

Research in the Speed group will focus on synthesis and catalysis mediated by complexes of heavier main group elements. Focused transformations involve activation of small molecules, followed by the addition of the activated molecule to unsaturated functional groups. Targeted transformations will either increase the generality and efficiency of known transformations, or develop new chemistry to explore previously underexplored chemical structures. Methodology developed will be challenged by the synthesis of molecules of interest to a variety of fields.

近期论文

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Adams, Matt R.; Tien, Chieh-Hung; Huchenski, Blake S. N.; Ferguson, Michael J.; Speed, Alexander W. H. "Diazaphospholene Precatalysts for Imine and Conjugate Reductions." Angewandte Chemie International Edition. 2017, in press Shen, Xiao.; Nguyen, Thach T.; Koh, Ming Joo; Xu, Dongmin; Speed, Alexander W. H.,Schrock, Richard R.; Hoveyda, Amir H. "Kinetically E-selective macrocyclic ring closing metathesis." Nature. 2017, 541, 380-385 Huchenski, Blake S. N.; Adams, Matt R.; McDonald, Robert; Ferguson, Michael J.; Speed, Alexander, W. H. "Synthesis and Catalytic Reactivity of Bis(amino)cyclopropenylidene Carbene–Borane Adducts." Organometallics. 2016, 35, 3101-3104. Speed, Alexander W. H.; Mann, Tyler J.; O’Brien, Robert V. III; Schrock, Richard R.;Hoveyda, Amir H. “Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C1.” J. Am. Chem. Soc. 2014, 136, 16136 – 16139 Mann, Tyler J.; Speed, Alexander W. H.; Schrock, Richard R.; Hoveyda, Amir H. “Catalytic Z- Selective Cross-Metathesis with Secondary Silyl- and Benzyl-Protected Allylic Ethers: Mechanistic Aspects and Applications to Natural Product Synthesis.” Angewandte Chem. Int. Ed. 2013, 52, 8395 – 8400. Marcoux, David; Bindschädler, Pascal; Speed, Alexander W. H.; Chiu, Anna; Pero, Joseph, E.; Borg, George A.; Evans, David A. “Effect of Counterion Structure on the Rates and Diastereoselectivities in a,b- Unsaturated Iminium-Ion Diels- Alder Reactions.” Org. Lett. 2011, 13, 3758 – 3761. Evans, David A.; Welch, Dennie S.; Speed, Alexander W. H.; Moniz, George A.; Reichelt, Andreas.; Ho, Stephen. “An Aldol-Based Synthesis of (+)-Peloruside A, A Potent Microtubule Stabilizing Agent.” J. Am. Chem. Soc. 2009, 131, 3840 – 3841. Pincock, J.A.; Speed, A.W.H. “Aromatic character and resonance stabilization energy of substituted cyclopentadienyl and indenyl cations.” Can. J. Chem., 2005, 83, 1287 – 1298.