Robertson, George - Dalhousie University - Department of Pharmacology

研究领域

Dr. George S. Robertson's primary research interest is finding ways to block the injurious events responsible for neurodegenerative disorders such as Alzheimer's disease, stroke, multiple sclerosis and Parkinson's disease. He is developing both small molecule (drug)- and gene therapy-based approaches to protect the brain from damage by improving mitochondrial performance.

近期论文

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Warford J., Jones Q.R.D., Nichols M., Sullivan V., Rupasinghe H.P.V. and Robertson G.S. (2014) The flavonoid-enriched fraction AF4 suppresses neuroinflammation and promotes restorative gene expression in a mouse model of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 268(1-2): 71-83. Wang H., Murphy R., Taaffe D., Yin S., Xia L., Hauswirth W.W., Bance M., Robertson G.S. and Wang J. (2012) Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane. Gene Therapy 19(3): 255-263. Jones Q.R., Warford J., Rupasinghe H.P. and Robertson G.S. (2012) Target-based selection of flavonoids for neurodegenerative disorders. Trends in Pharmacological Sciences 33(11): 602-610. Wang J., Menchenton T., Yin S., Yu Z., Bance M., Morris D.P., Moore C.S., Korneluk R.G. and Robertson G.S. (2010) Over-expression of X-linked inhibitor of apoptosis protein shows presbycusis in C57BL/6J mice. Neurobiology of Aging 31(7): 1238-1249. Xu D.G., Crocker S.J., Doucet J.-P., St- Jean M., Hakim A.M., Ikeda J.-E., Thompson C., Liston P., Korneluk R.G., MacKenzie A. and Robertson G.S. (1997) Elevation of neuronal expression of NAIP reduces ischemic damage in the hippocampus. Nature Medicine 3: 997-1004.