Pelis, Ryan - Dalhousie University - Department of Pharmacology

研究领域

Our research focuses on the impact that epithelial drug transport plays in regulating tissue-drug concentrations, and its potential involvement in drug-drug interactions and interindividual variability in drug exposure and response.

近期论文

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Lee J and Pelis RM. Drug transport by the blood-aqueous humor barrier of the eye. Drug Metab Dispos, 2016. Hotchkiss A, Berrigan L and Pelis RM. Organic anion transporter 2 transcript variant 1 shows broad selectivity when expressed in multiple cell lines. Front in Pharmacol 6:216, 2015. Hotchkiss A, Gao T, Khan U, Berrigan L, Li M, Ingraham L and Pelis RM. Organic anion transporter 1 is inhibited by multiple mechanisms and shows a transport mode independent of of exchange. Drug Metab Dispos 43:1847-54, 2015. Lee J, Shahidullah M, Hotchkiss A, Coca-Prados M, Delamere NA and Pelis RM. A renal-like organic anion transport system in the ciliary epithelium of the eye.Mol Pharmacol87: 697-705, 2015. Ingraham L, Li M, Renfro JL, Parker S, Vapurcuyan A, Hanna Iand Pelis RM. A plasma concentration ofa-ketoglutarateinfluences the kinetic interaction of ligands with OAT1.Mol Pharmacol86: 86-95, 2014.