Dupré, Denis - Dalhousie University - Department of Pharmacology

研究领域

In our lab, we study how G protein coupled receptors are involved in diseases like cancer or heart diseases. Many different therapies block GPCRs signaling at the cell surface but sometimes cause side effects. Our goal is to understand how the receptors get expressed to the cell surface where they cause the disease. We identify new ways to block receptor expression, trafficking or assembly with specific proteins to regulate how GPCRs function and participate in diseases. One of our goals is to identify new targets to block cancer metastasis.

近期论文

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Gillies K, Wertman J, Charette N, Dupré DJ, Anterograde trafficking of CXCR4 and CCR2 homo and heterodimers in a prostate cancer cell line. Cell Physiology and Biochemistry, 2013 Jul 5;32(1):74-85 Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupré DJ, Dopamine receptor interacting protein 78 acts as a molecular chaperone for chemokine receptors signaling complex organization. PLoS ONE, 2012 7(7): e40522 Kuang YQ, Pang W, Zheng YT, Dupré DJ: NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. European Journal of Immunology, 2012 Feb;42(2):299-310 Charette N, Holland P, Frazer J, Allen H, Dupré DJ: Dependence on Different Rab GTPases for the Trafficking of CXCR4 and CCR5 Homo or Heterodimers Between the Endoplasmic Reticulum and Plasma Membrane in Jurkat Cells. Cellular Signalling (2011) 23, 1738–1749 Hammad MM, Kuang YQ, Yan R, Allen H, Dupré DJ. NA+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction, but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. Journal of Biological Chemistry 2010 Nov 5; 285(45):34653–34664