Lautens, Mark - University of Toronto - Department of Chemistry

个人简介

J. Bryan Jones Distinguished Professor (2013-2023) AstraZeneca Professor of Organic Chemistry NSERC/Merck-Frosst Industrial Research Chair (2003-2013)

研究领域

The Lautens group is focused on the investigation and development of novel transition-metal-mediated organic transformations. Some projects include catalyst-controlled asymmetric transformations while others focus on controlled tandem or domino processes. Of particular interest are reactions which can efficiently construct frameworks of pharmaceutical compounds or fragments of biologically-active natural products.

近期论文

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Reversble C-C Bond Formation Using Palladium Catalysis Austin D. Marchese, Bijan Mirabi, Colton E. Johnson, Mark Lautens Nat. Chem. 2022, ASAP, ASAP-ASAP. DOI: 10.1038/s41557-022-00898-0 . Synthesis of Indenes and Benzofulvenes via a Palladium-Catalyzed Three-Component Reaction Xavier Abel-Snape, Gina Wycich, Mark Lautens ACS Catal. 2022, 12, 3291-3301. DOI: 10.1021/acscatal.1c06046 . A Modular Approach for the Palladium-Catalyzed Synthesis of Bis-heterocyclic Spirocycles Austin D. Marchese, Andrew G. Durant, Mark Lautens Org. Lett. 2022, 24, 95-99. DOI: 10.1021/acs.orglett.1c03682 . Dearomative Cyclopropanation of Naphthols via Cyclopropene Ring-Opening Rachel J. Baker, Justin Ching, Teh Ren Hou, Ivan Franzoni, Mark Lautens Angew. Chem. Int. Ed. 2021, ASAP, ASAP2-ASAP3. DOI: 10.1002/anie.202116171 . Accessing Unsymmetrically Linked Heterocycles through Stereoselective Palladium-Catalyzed Domino Cyclization Ramon Arora, Jose F. Rodriguez, Andrew Whyte, Mark Lautens Angew. Chem. Int. Ed. 2021, ASAP, ASAP-ASAP2. DOI: 10.1002/anie.202112288 . Nickel-Catalyzed Reductive Cross-Coupling of Heteroaryl Chlorides and Aryl Chlorides Bijan Mirabi, Austin D. Marchese, Mark Lautens ACS Catal. 2021, 11, 12785-12793. DOI: 10.1021/acscatal.1c02307 . Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides Jose F. Rodriguez, Anji Zhang, Ramon Arora, Mark Lautens Org. Lett. 2021, 23, 7540-7544. DOI: 10.1021/acs.orglett.1c02750 . Sequential Pd(0)- and Pd(II)-Catalyzed Cyclizations: Enantioselective Heck and Nucleopalladation Reactions Andrew Whyte, Jonathan Bajohr, Ramon Arora, Alexa Torelli, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 20231-20236. DOI: 10.1002/anie.202106518 . Iron-Catalyzed Reductive Cyclization by Hydromagnesiation: A Modular Strategy Towards N-Heterocycles Joachim Loup, Egor M. Larin, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 22345-22351. DOI: 10.1002/anie.202106996 . Enantioselective Synthesis of Spiro-oxiranes: An Asymmetric Addition/Aldol/Spirocyclization Domino Cascade Ken-Loon Choo, Bijan Mirabi, Karl Z. Demmans, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 21189-21194. DOI: 10.1002/anie.202105562 . Cycloisomerization of Carbamoyl Chlorides in Hexafluoroisopropanol: Stereoselective Synthesis of Chlorinated Methylene Oxindoles and Quinolinones Jose F. Rodriguez, Anji Zhang, Jonathan Bajohr, Andrew Whyte, Bijan Mirabi, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 18478-18483. DOI: 10.1002/anie.202103323 . Enantio- and Diastereodivergent Sequential Catalysis Featuring Two Transition Metal-Catalyzed Asymmetric Reactions Jeanne Masson-Makdissi, Liher Prieto, Xavier Abel-Snape, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 16932-16936. DOI: 10.1002/anie.202105800 . Recent Strategies for Carbon-Halogen Bond Formation Using Nickel Austin D. Marchese, Timur Adrianov, Mark Lautens Angew. Chem. Int. Ed. 2021, 60, 16750-16762. DOI: 10.1002/anie.202101324 . Palladium-Catalyzed Domino Heck/Sulfination: Synthesis of Sulfonylated Hetero- and Carbocyclic Scaffolds Using DABCO-Bis(sulfur dioxide) Jonathan Bajohr, Abdoul G. Diallo, Andrew Whyte, Sylvain Gaillard, Jean-Luc Renaud, Mark Lautens Org. Lett. 2021, 23, 2797-2801. DOI: 10.1021/acs.orglett.1c00716 . Recent Advances in Transition-Metal-Free (4+3)-Annulations Heather Lam, Xavier Abel-Snape, Martin F. Köllen, Mark Lautens Synthesis 2021, ASAP, ASAP3-ASAP2. DOI: 10.1055/s-0040-1706023 . One-Pot, Three-Step Synthesis of Benzoxazinones via Use of the Bpin Group as a Masked Nucleophile Egor M. Larin, Alexa Torelli, Joachim Loup, Mark Lautens Org. Lett. 2021, 23, 2720-2725. DOI: 10.1021/acs.orglett.1c00623 . Catalytic Asymmetric Transformations of Oxa- and Azabicyclic Alkenes Sundaravel Vivek Kumar, Andy Yen, Mark Lautens, Patrick J. Guiry Chem. Soc. Rev. 2021, 50, 3013-3093. DOI: 10.1039/D0CS00702A . Synthesis of Carbocyclic Compounds via a Nickel-Catalyzed Carboiodination Reaction Austin D. Marchese, Timur Adrianov, Martin F. Kollen, Bijan Mirabi, Mark Lautens ACS Catal. 2021, 11, 925-931. DOI: 10.1021/acscatal.0c04956 . Stereoselective Construction of y-Lactams via Copper-Catalyzed Borylacylation Alexa Torelli, Andrew Whyte, Iuliia Polishchuk, Jonathan Bajohr, Mark Lautens Org. Lett. 2020, 22, 7915-7919. DOI: 10.1021/acs.orglett.0c02837 . Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis Xavier Abel-Snape, Andrew Whyte, Mark Lautens Org. Lett. 2020, 22, 7920-7925. DOI: 10.1021/acs.orglett.0c02850 .