Gray, Michael - Dalhousie University - Department of Biochemistry & Molecular Biology

研究领域

Mitochondria and Ribosomes: Structure, Function and Evolution For over four decades, my research program has centered on the origin and evolution of mitochondria and ribosomes, two complex subcellular structures in eukaryotic (nucleus-containing) cells. My group has explored gene evolution in mitochondrial and nuclear DNA of protists (mostly unicellular eukaryotes), and investigated the biochemistry of unique aspects of gene expression in mitochondria, such as RNA editing. Additionally, we have investigated naturally fragmented rRNAs that result from extensive and novel processing of rRNA precursors. The latter project also focused on small nucleolar RNAs (snoRNAs), which mediate post-transcriptional modification, such as ribose methylation and pseudouridine formation, in rRNA. Protist Genomics Currently, I am involved in the analysis and annotation of genome data generated from several different genome sequencing projects focused on protists, including two amoebozoons, Acanthamoeba castellanii and Physarum polycephalum, two nucleomorph-containing algae, Bigelowiella natans and Guillardia theta, and a number of eukaryotic microbes (protists and fungi) selected to explore the origins of multicellularity in animals and fungi (http://www.broadinstitute.org/annotation/genome/multicellularity_project/MultiHome.html).

近期论文

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Gray, M.W., (2015) The mosaic nature of the mitochondrial proteome: implications for the origin and evolution of mitochondria. Proc. Natl. Acad. Sci. U.S.A. 112:10133-10138 [PubMed] [Article] David, V., Flegontov, P., Gerasimov, E.,Tanifuji, G.,Hashimi, H., Logacheva, M.G., Maruyama, S., Onodera, N.T., Gray, M.W., Archibald, J.M. and Lukeš, J., (2015) Gene loss and error-prone RNA editing in the mitochondrion of Perkinsela, an endosymbiotic kinetoplastid. mBio 6:e01498-15 Gray, M.W., (2014) Organelle evolution, fragmented ribosomal RNAs, and Carl. RNA Biol. 11:213-216 [PubMed] [Article] Abad, M.G., Long, Y., Kinchen, D., Schindel, E.T., Gray, M.W. and Jackman, J.E., (2014) Mitochondrial tRNA 5′-editing in Dictyostelium discoideum and Polysphondylium pallidum. J. Biol. Chem. 289:15155-15165 [PubMed] [Article] Gawryluk, R.M.R., Chisholm, K.A., Pinto, D.M. and Gray, M.W., (2014) Compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa) rivals that of animals, fungi, and plants. J. Proteomics 109:400-416 [PubMed] [Article] Gawryluk, R.M.R., Chisholm, K.A., Pinto, D.M. and Gray, M.W., (2014) Data showing the compositional complexity of the mitochondrial proteome of a unicellular eukaryote (Acanthamoeba castellanii, supergroup Amoebozoa). Data in Brief 1:12-14 Valach, M., Burger, G., Gray, M.W. and Lang, B.F., (2014) Widespread occurrence of mitochondrial genome-encoded 5S rRNAs including permuted molecules. Nucleic Acids Res. 42:13764-13777 [PubMed] [Article] Gray, M.W., (2013) The pre-endosymbiont hypothesis: a new perspective on the origin and evolution of mitochondria. Cold Spring Harb. Perspect. Biol. 6: a016097 [PubMed] Rao, B.S., Mohammad, F., Gray, M.W. and Jackman, J.E. , (2013) Absence of a universal element for tRNAHis identity in Acanthamoeba castellanii. Nucleic Acids Res. 41:1885-1894 [PubMed] Li, L., Nelson, C.J., Carrie, C., Gawryluk, R.M.R., Solheim, C., Gray, M.W., Whelan, J. and Millar, A.H., (2013) Subcomplexes of ancestral respiratory complex I subunits rapidly turn over in vivo as productive assembly intermediates in Arabidopsis. J. Biol. Chem. 288:5707-5717 [PubMed] Gray, M. W., (2013) Mitochondrial genomes. Molecular Life Sciences: An Encyclopedic Reference, E. Bell, J. S. Bond, J. P. Klinman, B. S. S. Masters and R. D. Wells (eds.), Springer:DOI: 10.1007/SpringerReference_333640 2014-03-20 13:49:09 UTC Burger, G., Gray, M.W., Forget, L. and Lang, B.F., (2013) Strikingly bacteria-like and gene-rich mitochondrial genomes throughout jakobid protists. Genome Biol. Evol. 5:418-438 [PubMed] Gray, M.W., (2013) RNA editing: evolutionary implications. eLS 2013 John Wiley & Sons, Ltd., Chichester: DOI: 10.1002/9780470015902.a0003069.pub3 Leger, M.M., Gawryluk, R.M.R., Gray, M.W. and Roger, A.J. , (2013) Evidence for a hydrogenosomal-type ATP generation system in Acanthamoeba castellanii. PLoS One 8:e69532 [PubMed] [Article] Wideman, J.G., Gawryluk, R.M.R., Gray, M.W. and Dacks, J.B., (2013) The ancient and widespread nature of the ER-Mitochondria Encounter Structure. Mol. Biol. Evol. 30:2044-2049 [PubMed] Pombert J.-F., Smirnov, A, James, E.R., Janouškovec, J., Gray, M.W. and Keeling, P.J., (2013) The complete mitochondrial genome from an unidentified Phalansterium species. Protist Genomics 1:26-32 [Article] Gray, M.W., (2012) Organelles. Brenner's Online Encyclopedia of Genetics 2E, S. Maloy and K. Hughes (eds.), Academic Press: in press Gray, M.W., (2012) Mitochondria. Brenner's Online Encyclopedia of Genetics 2E, S. Maloy and K. Hughes (eds.), Academic Press: in press Gray, M.W., (2012) Mitochondrial DNA. Brenner's Online Encyclopedia of Genetics 2E, S. Maloy and K. Hughes (eds.), Academic Press : in press Gray, M.W., (2012) Mitochondrial genome. Brenner's Online Encyclopedia of Genetics 2E, S. Maloy and K. Hughes (eds.), Academic Press : in press Gray, M.W., (2012) Mitochondrial mutants. Brenner's Online Encyclopedia of Genetics 2E, S. Maloy and K. Hughes (eds.), Academic Press : in press Gray, M.W. and Archibald, J.M., (2012) Origins of mitochondria and plastids. Genomics of Chloroplasts and Mitochondria, R. Bock and V. Knoop (eds.) Springer, Dordrecht:1-30 Jackman, J.E., Gott, J.M. and Gray, M.W., (2012) Doing it in reverse: 3′-to-5′ polymerization by the Thg1 superfamily. RNA 18:886-899 [PubMed] Gray, M.W., (2012) Mitochondrial evolution Cold Spring Harb Perspect Biol 4:a011403 [PubMed] Gawryluk, R.M.R., Chisholm, K.A., Pinto, D.M. and Gray, M.W., (2012) Composition of the mitochondrial electron transport chain in Acanthamoeba castellanii: structural and evolutionary insights Biochim. Biophys. Acta 1817:2027-2037 [PubMed]