GUNNING, Patrick T. - University of Toronto

个人简介

2011 Dean's Research Excellence Award at University of Toronto Mississauga 2011 CSC Ichikizaki Fund for Young Chemists Award - CSC University of Glasgow Young Alumnus of the Year 2010 - University of Glasgow Boehringer Ingelheim Young Investigator Award - Boehringer Ingelheim Early Researcher Award - Ministry of Innovation, Ontario Government David Rae Memorial Award - Leukemia and Lymphoma Society of Canada Connaught Staff-Matching Award - Connaught Foundation

研究领域

Chemistry/Organic and Inorganic Synthesis

近期论文

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Haftchenary, S., Luchman, H.; Jouk, A.; Veloso, A.; Page, B.; Cheng, X.; Dawson, S.; Grinshtein, N.; Shahani, V.; Kerman, K.; Kaplan, D.; Griffin, C.; Aman, A.; Al-awar, R.; Weiss, S., Gunning, P. T., Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. ACS Med. Chem. Lett., 2013 Page, B. D. G., Croucher, D., Li, Z., Wong, Y. L., Haftchenary, S., Jimenez-Zepeda, V., Atkinson, J., Spagnuolo, P., Schimmer, A. D., Trudel, S., Gunning, P. T.*, Inhibiting Activated Stat3 Protein with Tetrapodal, Small Molecule SH2 domain binders: Potent in vitro and Primary Multiple Myeloma Tumour Cell Activities.. J. Med. Chem., 2013 Kraskouskaya, D., Drewry, J. A., Duodu, E., Burger, S., Eaton, J., Cisneros, G. A., Gunning, P. T.*, Exploring the structural determinants of selective phosphopeptide recognition using bivalent metal-coordination complexes.. Med. Chem. Comm., 2013 Haftchenary, S., Ball, D. P., Aubry, I., Landry, M., Shahani, V. M., Fletcher, S., Page, B. D. G., Jouk, A. O., Tremblay, M. L., Gunning, P. T.*, Identification of potent salicylic acid-based inhibitors of tyrosine phosphatase PTP1B. Med. Chem. Comm., 2013 Shahani, V. M., Ball, D. P., Ramos, A. V., Li, Z., Spagnuolo, P. A., Haftchenary, S., Schimmer, A. D., Trudel, S. L., Gunning, P. T., A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.. Bioorg. Med. Chem. , 2013 da Silva, S., Paiva, S-L., Lukkarila, J., Gunning, P. T.*, Exploring a new frontier in cancer treatment: Targeting the ubiquitin and ubiquitin-like activating enzymes. J. Med. Chem., 2013 Camporeale, A., Marino, F., Papageorgiou, A., Carai, P., Fornero, S., Fletcher, S., Page, B. D. G., Gunning, P. T.,* Chiarle, R., Morello, M., Jenssen, O., Levi, R., Heymans, S., Poli, V.*, A crucial role for STAT3 in the pathogenesis of immune-mediated myocarditis.. EMBO Mol. Med., 2013 Avadisian, M. A., Gunning, P. T.*, Extolling the Benefits of Molecular Therapeutic Lipidification.. Mol. Bio. Syst., 2013 Zhang, W., daSilva, S., Pavia, S. L., Lukkarila, J., Schimmer, A. D., Gunning, P. T.*, Progress toward potent and selective inhibitors of UAE enzyme.. Curr. Pharma. Design, 2013 Kraskouskaya, D., Duodu, E., Gunning, P. T.*, Progress toward the development of SH2 domain inhibitors. Chem. Soc. Rev., 2013 Drewry, J. A., Duodu, E., Mazouchi, A., Spaganueulo, P., Burger, S., Gradinaru, C., Ayers, P., Schimmer, A. D., Gunning, P. T.*, Phosphopeptide Selective Coordination Complexes as Promising Src Homology 2 Domain Mimetics.. Inorg. Chem., 2012 Zhang,X, Yue,P., Page, B. D. G., Lia, T., Zhao, W., Namanja, A., Paladino, D., Zhao, J., Chen,Y., Gunning, P. T., Turkson, J., An orally-bioavailable small-molecule Stat3 inhibitor regresses human breast and lung cancer xenografts.. PNAS, 2012 Drewry, J. A., Burger, S., Mazouchi, A., Duodu, E., Ayers, P., Gradinaru, C. C., Gunning, P. T., Src Homology 2 Domain Proteomimetics: Developing Phosphopeptide Selective Receptors.. Med. Chem. Comm., 2012 Cumaraswamy, A. A., Gunning, P. T., Progress towards direct inhibitors of Stat5 protein. Hormone Mol. Biol. Clin. Investig., 2012 Burger, S. K., Lacasse, M., Verstraelen, T., Drewry, J. A., Gunning, P. T., Ayers, P. W., Automated Parameterization of AMBER force field terms from vibrational analysis with a focus on functionalizing dinuclear zinc(II) scaffolds.. J. Chem. Theor. Comput., 2012 Cumaraswamy, A., Todic, A., Resetca, D., Minden, M., Gunning, P. T., Inhibitors of Stat5 protein signalling.. RSC Med. Chem. Comm., 2012 Page,B. D. G., Khoury, H., Laister, R. C., Fletcher, S., Vellozo, M., Manzoli, A., Yue, P., Turkson, J., Minden, M. D., Gunning, P. T., Small molecule STAT5-SH2 domain inhibitors exhibit potent anti-leukemia activity.. J. Med. Chem., 2012 Mitra, R. N., Doshi, M., Zhang, Z., Tyus, J. C., Bengtsson, N., Fletcher, S., Page, B. D. G., Turkson, J., Gesquiere, A. J., Gunning, P. T., Walter G. A., Santra, S., An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.. Biomaterials, 2012 Page, B. D. G., Fletcher, S., Li, Z., Yue, P., Zhang, X., Sharmeen, S., Trudel, S., Schimmer, A. D., Turkson, J., Gunning, P. T., Identification of a Nonphosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain.. Bioorg. Med. Chem. Lett., 2011 Lukkarila, J., Ali, M., da Silva, S., Shahani, V. M., Xu, W. G., Berman, J., Roughton, A., Dhe-Paganon, S., Schimmer, A. D., Gunning, P. T., Identification of NAE inhibitors exhibiting potent activity in K562 leukemia cells: exploring the structural determinants of NAE specificity.. ACS Med. Chem. Lett., 2011 Avadisian, M., Fletcher, S., Lui, B., Zhao, W., Zhang, X., Yue, P., Badali, D., Xu, W., Schimmer, A. D., Turkson, J., Gradinaru, C. C., Gunning, P. T., Artificially Induced Protein-Membrane Anchorage with Cholesterol-based Recognition Agents: Towards a New Therapeutic Concept.. Angewandte Chemie Intl, 2011