个人简介
工作经历
2009年9月-2010年11月 美国密歇根大学 博士后
2010年11月-2012年3月 日本东京大学 JSPS博士后
2012年3月-2021年9月 中国科学技术大学 副教授
2021年10月-至今 西安交通大学 教授
教育经历
2000年9月-2004年7月 安徽大学 应用化学 学士
2004年9月-2009年7月 中国科学技术大学 高分子化学与物理 博士
研究领域
研究工作主要集中在高分子合成化学,自组装,高分子新材料设计与制备,生物医用高分子,药物传输,组织工程材料等。
近期论文
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D. Dutta, Q. Zhou, J. F. Mukerabigwi, N. Lu,* and Z. S. Ge*, Hypoxia-Responsive Polyprodrug Nanocarriers for Near-Infrared Light-Boosted Photodynamic Chemotherapy. Biomacromolecules 2021, DOI: 10.1021/acs.biomac.1c01152.
A. M. M. Japir, W. Ke, J. Li, J. F. Mukerabigwi, A. Ibrahim, Y. Wang, X. Li, Q. Zhou, F. Mohammed, Z. S. Ge*, Tumor-dilated polymersome nanofactories for enhanced enzyme prodrug chemo-immunotherapy, Journal of Controlled Release 2021, 339, 418-429.
Q. H. Zhou, F. Mohammed, Y. H. Wang, J. B. Wang, N. N. Lu, J. J. Li*, Z. S. Ge*, Hypoxia-responsive block copolymer polyprodrugs for complementary photodynamic-chemotherapy, Journal of Controlled Release 2021, 339, 130-142.
J. J. Li, Z. S. Ge*; K. Toh, X. Liu, A. Dirisala, W. Ke, P. Wen, H. Zhou, Z. Wang, S. Xiao, J. F. R. Van Guyse, T. A. Tockary, J. Xie, D. Gonzalez-Carter, H. Kinoh, S. Uchida, Y. Anraku, and K. Kataoka*, Advanced Materials 2021, 2105254.
Q. H. Zhou; Y. H. Wang; X. Li; N. N. Lu; Z. S. Ge*, Polymersome Nanoreactor-Mediated Combination Chemodynamic-Immunotherapy via ROS Production and Enhanced STING Activation. Advanced Therapeutics 2021, 2100130.
L. C. Xi; J. B. Wang; Y. H. Wang; Z. S. Ge*, Dual-Targeting Polymeric Nanocarriers to Deliver ROS-Responsive Prodrugs and Combat Multidrug Resistance of Cancer Cells. Macromolecular Bioscience 2021, 21, (9), 2100091.
Q. H. Zhou; Y. Zhou; T. Y. Li; Z. S. Ge*, Nanoparticle-Mediated STING Agonist Delivery for Enhanced Cancer Immunotherapy. Macromolecular Bioscience 2021, 21, (8), 2100133.
Y. H. Wang; S. Zhang; J. B. Wang; Q. H. Zhou; J. F. Mukerabigwi; W. D. Ke; N. N. Lu; Z. S. Ge*, Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy. Journal of Controlled Release 2021, 333, 500-510.
N. N. Lu; L. C. Xi; Z. S. Zha; Y. H. Wang; X. H. Han*; Z. S. Ge*, Acid-responsive endosomolytic polymeric nanoparticles with amplification of intracellular oxidative stress for prodrug delivery and activation dagger. Biomaterials Science 2021, 9, (13), 4613-4629.
J. F. Mukerabigwi; Y. Han; N. N. Lu; W. D. Ke; Y. H. Wang; Q. H. Zhou; F. Mohammed; A. Ibrahim; B. Zheng*; Z. S. Ge*, Cisplatin resistance reversal in lung cancer by tumor acidity-activable vesicular nanoreactors via tumor oxidative stress amplification dagger. Journal of Materials Chemistry B 2021, 9, (13), 3055-3067.
Y. Huang; L. Z. Huang; L. Li; Z. S. Ge; G. J. Feng*; L. M. Liu; Y. M. Song, MicroRNA-25-3p therapy for intervertebral disc degeneration by targeting the IL-1 beta/ZIP8/MTF1 signaling pathway with a novel thermo-responsive vector. Annals of Translational Medicine 2020, 8, (22), 1500.
A. W. M. M. Japir; N. N. Lu; Y. H. Wang; J. F. Mukerabigwi; Q. H. Zhou; Z. S. Ge*, Membrane-cross-linked polymersomes with tumor pH-tunable selective permeability as intelligent nanoreactors and drug delivery vehicles. European Polymer Journal 2020, 138, 109982.
W. Yin; W. D. Ke; N. N. Lu; Y. H. Wang; A. W. M. M. Japir; F. Mohammed; Y. Wang; Y. Y. Pan*; Z. S. Ge*, Glutathione and Reactive Oxygen Species Dual-Responsive Block Copolymer Prodrugs for Boosting Tumor Site-Specific Drug Release and Enhanced Antitumor Efficacy. Biomacromolecules 2020, 21, (2), 921-929.
W. D. Ke; N. N. Lu; A. M. M. Japir; Q. H. Zhou; L. C. Xi; Y. H. Wang; D. Dutta; M. Zhou; Y. Y. Pan; Z. S. Ge*, Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency. Journal of Controlled Release 2020, 318, 67-77.
A. Ibrahim; E. Twizeyimana; N. N. Lu; W. D. Ke; J. F. Mukerabigwi; F. Mohammed; A. W. M. M. Japir; Z. S. Ge*, Reduction-Responsive Polymer Prodrug Micelles with Enhanced Endosomal Escape Capability for Efficient Intracellular Translocation and Drug Release. Acs Applied Bio Materials 2019, 2, (11), 5099-5109.
F. Mohammed; W. D. Ke; J. F. Mukerabigwi; A. M. M. Japir; A. Ibrahim; Y. H. Wang; Z. S. Zha; N. N. Lu; M. Zhou; Z. S. Ge*, ROS-Responsive Polymeric Nanocarriers with Photoinduced Exposure of Cell-Penetrating Moieties for Specific Intracellular Drug Delivery. Acs Applied Materials & Interfaces 2019, 11, (35), 31681-31692.
D. Dutta; W. D. Ke; L. C. Xi; W. Yin; M. Zhou*; Z. S. Ge*, Block copolymer prodrugs: Synthesis, self-assembly, and applications for cancer therapy. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology 2020, 12, (1), e1585.
J. F. Mukerabigwi; W. Yin; Z. S. Zha; W. D. Ke; Y. H. Wang; W. J. Chen; A. M. M. Japir; Y. Wang; Z. S. Ge*, Polymersome nanoreactors with tumor pH-triggered selective membrane permeability for prodrug delivery, activation, and combined oxidation-chemotherapy. Journal of Controlled Release 2019, 303, 209-222.
W. Yin; W. D. Ke; W. J. Chen; L. C. Xi; Q. H. Zhou; J. F. Mukerabigwi; Z. S. Ge*, Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release. Biomaterials 2019, 195, 63-74.
W. D. Ke; J. J. Li; F. Mohammed; Y. H. Wang; K. Tou; X. Y. Liu; P. Y. Wen; H. Kinoh; Y. Anraku; H. B. Chen; K. Kataoka; Z. S. Ge*, Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy. Acs Nano 2019, 13, (2), 2357-2369.