张洪彬 - 云南大学

个人简介

教育经历 1995/07-1998/12 澳大利亚国立大学，化学研究院，博士（PhD）； 1985/09-1988/07 中国科学院，上海药物研究所，理学硕士； 1981/09-1985/07 云南大学，化学系，理学学士工作经历 2023.04-至今，云南大学药学院，自然资源药物化学教育部重点实验室，教授 2016.11-2023.04，云南大学，自然资源药物化学教育部重点实验室，教授 2005.12-2016.11，云南大学化学科学与工程学院，自然资源药物化学教育部重点实验室，教授 2000.06-2005.11，云南大学药学院，药物化学，教授

研究领域

1) 结构单元导向的生物活性天然产物全合成：设计串联反应，发展针对特定天然产物结构单元的合成新方法，实现复杂生物活性天然产物的普适性全合成。 2) 生物活性分子设计、合成及构效关系：发展药效团合成新方法，利用药效团拼接方法设计新化合物和用于天然产物结构编辑改造，发现化合物活性及构效关系、结构优化并与药理学课题组合作进行作用机制研究

近期论文

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Hongchang Tian, Yinxia Wu, Xiujuan Li, Zhen Hao, Wenyan He, Xiangdi Huang, Wen Chen*, Hongbin Zhang*, Total syntheses of Kopsaporine, Kopsinol and Kopsiloscine A. Angewandte Chemie International Edition 2023, 62, e202218935. (IF = 16.823) Shengzu Duan, Ya Du, Lingling Wang, Xun Tian, Yujin Zi, Hongbin Zhang*, Patrick J. Walsh*, Xiaodong Yang*, Catalytic Chemo- and Regioselective Radical Carbocyanation of 2-Azadienes for the Synthesis of α-Amino Nitriles. Angewandte Chemie International Edition 2023, 62, e202300605. (IF = 16.823) Shiyuan Kang#, Yinxia Wu#, Min Hu, Ying Ma, Xiangdi Huang, Zhen Hao, Xiujuan Li, Wen Chen*, Hongbin Zhang*, Total synthesis of Vinorine. Organic Letters, 2023, DOI: 10.1021/acs.orglett.3c01041. (IF = 6.072) Wen Chen, Yonghui Ma, Wenyan He, Yinxia Wu, Yuancheng Huang, Yipeng Zhang, Hongchang Tian, Kai Wei, Xiaodong Yang*, Hongbin Zhang*, Structure units oriented approach towards collective synthesis of Sarpagine-Ajmaline-Koumine type alkaloids. Nature Communications 2022, 13, 908. (IF = 17.694) Rui Li, Kai Wei, Wen Chen, Liang Li, Hongbin Zhang*, Carbon−Sulfur Bond Formation: Tandem Process for the Synthesis of Functionalized Isothiazoles. Organic Letters 2022, 24, 339-343. (IF = 6.072) Guogang Deng, Shengzu Duan, Jing Wang, Zhuo Chen, Tongqi Liu, Wen Chen, Hongbin Zhang*, Xiaodong Yang*, Patrick J. Walsh*, Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms. Nature Communications 2021, 12, 3860. (IF = 17.694) Wen-Yun Tan, Yi Lu, Jing-Feng Zhao, Wen Chen, Hongbin Zhang*, Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer. Organic Letters 2021, 23, 6648-6653. (IF = 6.072) Guogang Deng, Minyan Li, Kaili Yu, Chunxiang Liu, Zhengfen Liu, Shengzu Duan, Wen Chen, Xiaodong Yang*, Hongbin Zhang*, Patrick J. Walsh*, Synthesis of Benzofuran Derivatives through Cascade Radical Cyclization/Intermolecular Coupling of 2-Azaallyls. Angewandte Chemie International Edition 2019, 58, 2826-2830. (IF = 16.823) Yuxiang Zhao, Yanren Zhu, Guolan Ma, Qi Wei, Shaoxiong Yang, Xiaoyu Zeng, Hongbin Zhang* and Jingbo Chen* Short, enantioselective, gram-scale synthesis of (-)-zephyranthine. Chem. Sci., 2021, 12, 9452–9457. (IF = 9.969) Wen Chen, Xiao-Dong Yang, Wen-Yun Tan, Xiang-Yang Zhang, Xia-Li Liao, Hongbin Zhang*, Total synthesis of (–)-Vindorosine. Angewandte Chemie International Edition 2017, 56, 12327-12331. (IF = 16.823)