LASKO, Paul - McGill University - Department of Biology

个人简介

Paul Lasko received a Ph.D. in Biology from the Massachusetts Institute of Technology, where he carried out a genetic saturation of the chromosomal region surrounding the Drosophila vestigial gene in the laboratory of Mary Lou Pardue. He then moved to the laboratory of Michael Ashburner, in the Department of Genetics at Cambridge University, where he cloned and did an initial characterization of vasa. Paul Lasko joined the Biology Department at McGill University in April 1990, was promoted to Associate Professor in 1996 and to Full Professor in 1999. He has served as Biology Department Chair since June 2000, and is a founding member of the DBRI. Dr Lasko was a Research Scientist of the National Cancer Institute of Canada from 1992-98, won the Young Scientist Award of the Genetics Society of Canada in 1998 and its Award of Excellence in 2004, and is a contributor to the Faculty of 1000.

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Taruscio, D., Groft, S., Cederroth, H., Melegh, B., Lasko, P., Kosaki, K., Baynam, G., and Gahl, W. (2015) Undiagnosed Diseases Network International (UDNI): White paper for global actions to meet patient needs. Molecular Genetics of Metabolism 116: 223-225. PMID 26596705 Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., Balling, R., Berger, A. C., Bleyl, S., Chakravarti, A., Chantratita, W., Chisholm, R. L., Dissanayake, V. H. W., Dunn, M., Dzau, V. J., Han, B. G., Hubbard, T., Kolbe, A., Korf, B., Kubo, M., Lasko, P., Leego, E., Mahasirimongkol, S., Majumdar, P. P., Matthijs, G., McLeod, H. L., Metspalu, A., Meulien, P., Miyamo, S., Naparstek, Y., O’Rourke, P. P., Patrinos, G. P., Rehm, H. L., Relling, M. V., Rennert, G., Rodrigues, L. L., Roden, D. M., Shuldiner, A. R., Sinha, S., Tan, P., Ulfendahl, M., Ward, R., Williams, M. S., Wong, J. E. L., Green, E. D., and Ginsburg, G. S. (2015) Global implementation of genomic medicine: we are not alone. Science Translational Medicine 7: 290ps13. PMID 26041702 Liu, N. and Lasko, P. (2015) Analysis of RNA interference lines identifies new maternally- expressed genes involved in embryonic patterning in Drosophila melanogaster. G3-Genes, Genomes, Genetics 5: 1025-1034. PMID 25834215 Ghosh, S. and Lasko, P. (2015) Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis. PLoS ONE 10(4): e0122519. PMID 25849588 Dehghani, M. and Lasko, P. (2015) In vivo mapping of functional regions of the DEAD-box helicase Vasa. Biology Open 4: 450-457. PMID 25795910 Ivshina, M., Lasko, P., and Richter, J. D. (2014) Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annual Reviews of Cell and Developmental Biology 30: 393-415. PMID 25068488 Almouzni, G., Altucci, L., Amati, B., Ashley, N., Baulcombe, D., Beaujean, N., Bock, C., Bongcam-Rudloff, E., Bousquet, J., Braun, S., Paillerets, B.B., Bussemakers, M., Clarke, L., Conesa, A., Estivill, X., Fazeli, A., Grgurevi?, N., Gut, I., Heijmans, B.T., Hermouet, S., Houwing-Duistermaat, J., Iacobucci, I., Ilaš, J., Kandimalla, R., Krauss-Etschmann, S., Lasko, P., Lehmann, S., Lindroth, A., Majdi, G., Marcotte, E., Martinelli, G., Martinet, N., Meyer, E., Miceli, C., Mills, K., Moreno-Villanueva, M., Morvan, G., Nickel, D., Niesler, B., Nowacki, M., Nowak, J., Ossowski, S., Pelizzola, M., Pochet, R., Potonik, U., Radwanska, M., Raes, J., Rattray, M., Robinson, M.D., Roelen, B., Sauer, S., Schinzer, D., Slagboom, E., Spector, T., Stunnenberg, H.G., Tiligada, E., Torres-Padilla, M.E., Tsonaka, R., Soom, A.V., Vidakovi, M., and Widschwendter, M. (2014) Relationship between genome and epigenome –challenges for future research. BMC Genomics 15: 487. PMID 24942464 MacLeod, S., Lasko, P., and MacKenzie, A. (2014) The study of drugs for rare disorders: harnessing research contributions by Canadian academic institutions. Journal of Population Therapeutics and Clinical Pharmacology 21: e47-e55. PMID 24671865 Meulien, P., Lasko, P., MacKenzie, A., Bell, C., and Boycott, K. (2014) Rare diseases—how genomics has transformed thinking, diagnoses, and hope for affected families. In Bali, R. K., et al., eds., Orphan Diseases in the Age of Health 2.0, 2014, Berlin: Springer-Verlag, pp. 27-38. Solana, J., Gamberi, C., Mihaylova, Y., Grosswendt, S., Chen, C., Lasko, P., Rajewsky, N., and Aboobaker, A. A. (2013) The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. PLoS Genetics 9(12): e1004003. PMID 24367277 Lasko, P. (2013) The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology. BBA-Gene Regulatory Mechanisms 1829: 810-816. PMID 23587717 Hernández, G., Miron, M., Han, H., Liu, N., Magescas, J., Tettweiler, G., Frank, F., Siddiqui, N., Sonenberg, N., and Lasko, P. (2013) Mextli is a novel eIF4E binding protein that promotes translation in Drosophila. Molecular and Cellular Biology 33: 2854-2864. PMID 23716590 Lasko, P. (2013) New wrinkles on genetic control of the MBT. Current Biology 23: R65-R67. PMID 23347940 Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Paul, D., Truitt, M., Major, F., Lasko, P., Ruggero, D., Nader, K., Lacaille, J.-C., and Sonenberg, N. (2013) Autism-related defects via dysregulated eIF4E-dependent translational control. Nature 493: 371-377. PMID 2317214. Hernández, G., Han, H., Gandin, V., Fabian, L., Ferreira, T., Zuberek, J., Sonenberg, N., Brill, J. A., and Lasko, P. (2012) Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis, and male fertility in Drosophila. Development 139: 3211-3220. Lasko, P. (2012) mRNA localization and translational control in Drosophila oogenesis. Cold Spring Harbor Perspectives in Biology, 4 (10) doi: 10.1101/cshperspect.a012294 Tettweiler, G., Kowanda, M., Lasko, P., Sonenberg, N., and Hernández, G. (2012) The distribution of eIF4E-family members across Insecta. Comparative and Functional Genomics: 960420 (15 pages). Gamberi, C. and Lasko, P. (2012) The Bic-C family of developmental translational regulators. Comparative and Functional Genomics: 141386 (23 pages). Kong, J. and Lasko. P. (2012) Translational control in cellular and developmental processes. Nature Reviews of Genetics 13: 383-394. Richter, J. and Lasko, P. (2011) Translational control in oocyte development. Cold Spring Harb. Perspect. Biol. 3(9): a002758. Parsyan, A., Svitkin, Y., Shahbazian, D., Lasko, P., Merrick, W., and Sonenberg, N. (2011) mRNA helicases - the tacticians of translational control. Nature Rev. Mol. Cell Biol 12: 235-245. Lasko, P. (2011) Post-transcriptional regulation in Drosophila oocytes and early embryos. Wiley Interdisciplinary Reviews 2: 408-416. Lasko, P. (2010) Tudor domain. Curr. Biol. 20: R666-R667. Kugler, J.-M., Woo, J.-S., Oh, B.-H., and Lasko, P. (2010) Competitive regulation of Drosophila Vasa in vivo through paralogous Cullin-RING E3 ligase specificity receptors. Mol. Cell. Biol. 30: 1769-1782. Kugler, J.-M., Lem, C., and Lasko, P. (2010) Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila. PLoS ONE 5(2): e9048.