Sossin, Wayne - McGill University - Department of Anatomy and Cell Biology

研究领域

Biochemical and molecular mechanisms underlying memory formation and maintenance.

近期论文

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Nagakura I, Dunn TW, Abi-Farah C, Heppner A, Li FF, Sossin WS (2010) Regulation of Protetin Kinase C Apl II by serotonin receptors in Aplysia. J. Neurochem 115:994-1006 Hu JY, Chen Y, Bougie J, Sossin WS and Schacher S. (2010). Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses J. Neurosci 30:8353-66. Weatherill, D, Dyer JR and Sossin WS. (2010) Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia J. Biol. Chem. 285: 12255-12567 Abi-Farah C, Weatherill DW, Tyler, WJ and Sossin WS. PKC differentially translocates during spaced and massed training in Aplysia. J. Neurosci. 29:10281-6 Wang DO, Kim S, Zhao Y, Hwang H, Mioru S, Sossin WS and Martin KC (2009)Synapse- and stimulus-specific local translation during long-term neuronal plasticity Science 324:1536-40 Villareal,G Li, Q, Cai, D, Fink, A Lim, T Bougie J, Sossin WS and Glannzman D. (2009) Role of Protein Kinase C in the Induction and Maintenance of Serotonin-Dependent Enhancement of the Glutamate Response in Isolated Siphon Motor Neurons of Aplysia J. Neurosci 29:5100: Miller L, Blandford V, Sanchez-Carbente M, Badeaux F McAdam R, Desgroseillers L, and Sossin WS. (2009) Combinations of DEAD box proteins distinguish distinct types of RNA:protein complexes in neurons Mol Cell Neurosci 40:485-495 (Cover of Journal) Bougie JK, Lim T, Abi Farah C, Manjunath V, Nagakura I, Ferraro GB and Sossin WS (2009) The Atypical Protein Kinase C in Aplysia can form a PKM by cleavage. J. Neurochem 109:1129-1143 Nagakura I, Ormond J, Sossin WS (2008) Mechanisms regulating ApTrkl, a Trk-like receptor in Aplysia sensory neurons. J. Neurosci. Res. 86:2876-2883. Gobert D, Topolnik L, Azzil M, Huang L, Badeaux F, DesGroseillers L, Sossin WS and Lacaille L-C (2007) Forskolin induction of late-LTP and up-regulation of 5’TOP nRNAs translation via mTOR in hippocampal pyramidal cells. J Neurochem 106:1160-1174 Abi Farah C, Nagakura, I. Weatherill D, Fan X, and Sossin WS (2008) A physiological role for phosphatidic acid in the translocation of the novel protein kinase C APLII in Aplysia neurons. Mol. Cell Biol. 28:4719-4733 Lebeau G, Maher-Laporte M, Topolnik L Laurent CE, Sossin WS, DesGroseillers L and Lacaille J-C (2008) Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells. Mol. Cell. Biol. 28:2896-2907. Houeland, G; Nakhost, A, Sossin WS and Castellucci, V.F. (2007) PKC modulation of transmitter release by SNAP-25 at sensory to motor synapses in Aplysia. J. Neurophys. 97:134-143 Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille J-C, Nader K, N Sonenberg (2007) eIF2a phosphorylation bidirectionaly regulates the switch from short to long-term synaptic plasticity and memory. Cell 129(1):195-206. Carroll, M; Dyer, JR and Sossin WS (2006) Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in Aplysia neurons. Mol. Cell. Biol. 26(22):8586-8598. Zhao Y, Leal K, Abi-Farah C, Martin KC, Sossin WS, Klein M. (2006) Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitation. J Neurosci. 26:8847-8856. Ross G, Dyer, JR, Castellucci, VF and Sossin WS; (2006) Mnk is a negative regulator of cap-dependent translation in Aplysia neurons. J. Neurochem. 97:79-91. Elvira G, Wasiak S, Blandford V, Tong, X-K, Serrano, A, Fan X, del Rayo Sanchez-Carbente M, Servant F, Bell AW, Boismenu D, Lacaille, J-C, McPherson P, DesGroseillers L, Sossin WS. (2006) Characterization of a putative RNA granule from developing brain. Mol. Cell. Proteomics 5:635-651. Costa-Mattioli, M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidnosti M, Ben-Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello A.C., Seidah N, Sossin WS, Lacaille J-C, Ron D, Nader K, Sonenberg N. (2005) Translational control of hippocampal synaptic plasticity and memory by the eIF2a kinase, GCN2. Nature 436:1166-73. Ormond J, Hislop J, Zhao Y, Webb N, Villaincourt F, Dyer JR, Ferraro J. Barker, P, Martin KC and Sossin WS. (2004) ApTrkl, a Trk-like receptor, mediates serotonin-dependent ERK activation and long-term facilitation in Aplysia sensory neurons. Neuron 44:715-728 Carroll, M, Warren, O, Fan, X and Sossin WS. (2004) 5-HT stimulates eEF2 dephosphorylation in a rapamycin-sensitive manner in Aplysia neurites. J. Neurochem. 90: 1464-1476 Dyer JR, Michel S, Lee W, Castellucci VC, Wayne, N and Sossin WS. (2003) An activity dependent switch to cap-independent translation triggered by eIF4E dephosphorylation in neurons. Nature Neuroscience 6:219-220 Nakhost A, Houeland G, Castellucci VF and Sossin WS (2003). Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I J. Neurosci;; 23:6238-6244