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研究领域

Insulin and growth factor signaling, pathogenesis of Type 2 Diabetes Mellitus, proteomics of signaling in endosomes and other organelles.

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van Houten, M., Posner, B. I., Kopriwa, B. M. & Brawer, J. R. Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus. Science 207, 1081-1083 (1980). van Houten, M. & Posner, B. I. Insulin binds to brain blood vessels in vivo. Nature 282, 623-625 (1979). Bergeron, J. J., Cruz, J., Khan, M. N. & Posner, B. I. Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: the endosomal apparatus. Annu Rev Physiol 47, 383-403 (1985). Posner, B. I. et al. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. The Journal of biological chemistry 269, 4596-4604 (1994). Sladek, R. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007).

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