Reinhardt, Dieter P. - McGill University - Department of Anatomy and Cell Biology

研究领域

The dynamics of cell-extracellular matrix interactions in normal and pathological situations. Identification of disease mechanisms in heritable diseases originating in the extracellular matrix.

近期论文

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Hubmacher, D., Schneider, M., Berardinelli, S., Takeuchi, H., Willard, B., Reinhardt, D. P., Haltiwanger, R. S. and Apte, S. S. (2017). Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. Sci. Rep. in press: [Abstract] Zeyer, K. A. and Reinhardt, D. P. (2017). Fibrillin-1 in connective tissues. In: Marfan Syndrome. Eds. Marfan Hilfe e. V. Springer, Berlin (Germany). Chp. 13, 64-66. [Abstract not available] Schaefer, L. and Reinhardt, D. P. (2016). Extracellular matrix: Therapeutic tools and targets in cancer treatment. Adv. Drug Deliv. Rev. 97: 1-3 [Abstract] Loy, C., Meghezi, S., Lévesque, L., Pezzoli, D., Kumra, H., Reinhardt, D. P., Kizhakkedathu, J. N. and Mantovani, D. (2016). A planar model of the vessel wall from cellularized collagen scaffolds: focus on cell–matrix interactions in mono-, bi- and tri-culture models. Biomater. Sci. 5: 153-162 [Abstract] Li, C. D., Hancock, M. A., Seghal, P., Zhou, S., Reinhardt, D. P. and Philip, A. (2016). Soluble CD109 binds TGF-β and antagonizes TGF-β signaling and responses. Biochem. J. 473: 537-547 [Abstract] Kumra, H. and Reinhardt, D. P. (2016). Fibronectin-targeted drug delivery in cancer. Adv. Drug Deliv. Rev. 97: 101-110 [Abstract] Kahle, B., Schmidtke, C., Hunzelmann, N., Bartels, C., Sievers, H. H., Reinhardt, D. P. and Brinckmann, J. (2016). The extracellular matrix signature in vein graft disease. Can. J. Cardiol. 32: 1008.e11-7 [Abstract] Zeyer, K. A. and Reinhardt, D. P. (2015). Fibrillin-containing microfibrils are key signal relay stations for cell function. J. Cell Commun. Signal. 9: 309-325 [Abstract] Zeyer, K. and Reinhardt, D. P. (2015). Engineered mutations in fibrillin-1 leading to Marfan syndrome act at the protein and cellular levels. Mutat. Res. Rev. 765: 7-18 [Abstract] Kaur, J. and Reinhardt, D. P. (2015). Extracellular Matrix Molecules. In: Stem Cell Biology and Tissue Engineering in Dental Science. Eds. Vishwakarma, A., Sharpe, P. T., Shi, S., Wang, X. and Ramalingam, M. Elsevier, New York. Chp. 3, 25-43 [no abstract available] Hubmacher, D., Wang, L. W., Mecham, R. P., Reinhardt, D. P. and Apte, S. S. (2015). Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia: A novel mouse model providing insights on geleophysic dysplasia. Dis. Model. Mech. 8: 487-499 [Abstract] Hinderer, S., Shena, N., Ringuette, L. J., Hansmann, J., Reinhardt, D. P., Brucker, S. Y., Davis, E. C. and Schenke-Layland, K. (2015). In vitro elastogenesis - Instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold. Biomed. Mater. 10: 034102 [Abstract] Murphy, E. C., Mörgelin, M., Reinhardt, D. P., Björck, L., and Frick, I.-M. (2014). Finegoldia magna uses its cell surface and extracellular proteins, FAF and SufA, to colonise and pass into deeper fractions of human skin. Mol. Microbiol. 94: 403-417. [Abstract] Hubmacher, D., Reinhardt, D. P., Plesec, T., Schenke-Layland, K. and Apte, S. S. (2014). Human eye development is characterized by coordinated expression of fibrillin isoforms. Invest. Ophthalmol. Vis. Sci. 55: 7934-7944 [Abstract] Reinhardt, D. P. (2014). Microfibril-associated disorders: fibrillinopathies. J. Glaucoma 23: S34-S35. [Abstract] Marek, I., Volkert, G., Hilgers, K. F., Bieritz, B., Rascher, W., Reinhardt, D. P. and Hartner, A. (2014). Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey firm adhesion of mesangial cells. Cell Adh. Migr. 8: 389-395 [Abstract] Sabatier, L., Djokic, J., Hubmacher, D., Dzafik, D., Nelea, V., and Reinhardt, D. P. (2014). Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly. FEBS Lett. 588: 2890-2897. [Abstract] Hubmacher, D., Bergeron, E., Fagotto-Kaufmann, C., Sakai, L. Y., and Reinhardt, D. P. (2014). Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach. Biomacromolecules 15: 1456-1468. [Abstract] Muiznieks, L. D., Cirulis, J. T., van der Horst, A., Reinhardt, D. P., Wuite, G. J. L., Pomès, R. and Keeley, F. W. (2014). Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin. Matrix Biol. 36: 39-50 [Abstract] Djokic, J., Fagotto-Kaufmann, C., Bartels, R., Nelea, V. and Reinhardt, D. P. (2013). Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers. J. Biol. Chem. 288: 22821-22835 [Abstract] Hummitzsch, K., Irving-Rodgers, H. F., Hatzirodos, N., Bonner, W., Sabatier, L., Reinhardt, D. P., Sado, Y., Ninomiya, Y., Wilhelm, D., and Rodgers, R. J. (2013). A new model of development of the mammalian ovary and follicles. PLoS ONE 8: e55578- [Abstract] Votteler, M., Carvaja Berrio, D. A., Horke, A., Sabatier, L., Reinhardt, D. P., Nsair, A., Aikawa, E., and Schenke-Layland, K. (2013). Elastogenesis occurs at the early onset of human cardiac valve development. Development 140: 2345-2353. [Abstract] Tiedemann, K., Boraschi-Diaz, I., Rajakumar, I., Kaur, J., Roughley, P., Reinhardt*, D. P., and Komarova*, S. V. (2013). Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J. Cell Sci. 126: 4187-4194. [Abstract] *co-senior authors Beene, L. C., Wang, L. W., Hubmacher, D., Keene, D. R., Reinhardt, D. P., Annis, D. S., Mosher, D. F., Mecham, R. P., Traboulsi, E. I. and Apte, S. S. (2013). Non-selective assembly of fibrillin-1 and fibrillin-2 in the rodent ocular zonule and in cultured cells: Implications for Marfan syndrome. Invest. Ophthalmol. Vis. Sci. 54: 8337-8344 [Abstract] Sabatier, L., Djokic, J., Fagotto-Kaufmann, C., Chen, M., Annis, D. S., Mosher, D. F., and Reinhardt, D. P. (2013). Complex contributions of fibronectin to initiation and maturation of microfibrils. Biochem. J. 456: 283-295. [Abstract]