Whiteway, Malcolm - Concordia University

研究领域

Our ongoing research investigates the medically important fungal pathogen Candida albicans, with the ultimate goal of identifying new treatment options for patients suffering from Candida infections. We use an array of genetic and genomic approaches to investigate pathways involved in various C. albicans functions. As part of these efforts we collaborated with various international research teams in the assembly and annotation of the C. albicans genome. We are now using genome-based tools such as transcriptional profiling and ChIP-chip analysis to investigate regulatory circuits in the pathogen. We have identified dramatic cases of transcriptional rewiring of central metabolic pathways, synchronized cells and established the transcriptional profile of the C. albicans cell cycle, and investigated the regulation of the fungal mating system. We are also screening an extensive library of conditional C. albicans mutants using various physiological and chemical treatments through the functional Genomics robotic facility at Concordia. This will allow us to explore, tailor, and understand the subtleties that make C. albicans a human pathogen.

近期论文

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Tebbji F, Chen Y, Richard Albert J, Gunsalus KT, Kumamoto CA, Nantel A, Sellam A, Whiteway M. (2014) A functional portrait of Med7 and the mediator complex in Candida albicans. PLoS Genet. 10, e1004770. Epp E, Nazarova E, Regan H, Douglas LM, Konopka JB,Vogel J, Whiteway M. (2013) Clathrin-and Arp2/3-independent endocytosis in the fungal pathogen Candida albicans. MBio. 4: e00476-13. Ryan O, Shapiro RS, Kurat CF,Mayhew D, Baryshnikova A, Chin B, Lin Z-Y, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, Schwartzmuller T, Reynolds TB, Kuchler, K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras A-C, Mitra RD, Andrews B, Fink GR, Cowen L, Boone C. (2012) Global gene deletion analysis exploring yeast filamentous growth. Science 337: 1353-6. Askew C, Sellam A, Epp E, Mallick J, Hogues H, Mullick A, Nantel A, Whiteway M. (2011) The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion. Mol Microbiol.79: 940-53. Côte P, Sulea T, Dignard D, Wu C, and Whiteway M. (2011) Evolutionary reshaping of fungal mating pathway scaffold proteins. MBio 2: e00230-10. Lavoie H, Hogues H, Mallick J, Sellam A, Nantel A, Whiteway M. (2010) Evolutionary tinkering with conserved components of a transcriptional regulatory network. PLoS Biol. 8: e1000329. Walters Aji Tebung, Baharul I.Choudhury, Faiza Tebbji, Joachim Morschhäuser,Malcolm Whiteway (2016) In the Saccharomycetaceae the Ppr1 zinc clustertranscription factor has been rewired from purine catabolism to pyrimidinebiogenesis. Curr. Biol (in press) Sun Y, Gadoury C, Hirakawa MP, BennettRJ, Harcus D, Marcil A, Whiteway M.(2016) Deletion of aYci1 Domain Protein of Candida albicans Allows Homothallic Mating in MTLHeterozygous Cells. MBio. 7,e00465-16 Zhao Y, Yan H, Happeck R, Peiter-Volk T, XuH, Zhang Y, Peiter E, van Oostende Triplet C, Whiteway M, Jiang L. (2016) The plasma membrane protein Rch1 is anegative regulator of cytosolic calcium homeostasis and positively regulated bythe calcium/calcineurin signaling pathway in budding yeast. Eur JCell Biol. 95, 164-74 Mallick J, Jansen G, Wu C, Whiteway M. (2016) SRYTH: A New Yeast Two-Hybrid Method.Methods Mol Biol. 1356:31-41. Yan L, Xiong J, Lu H, Lv QZ, Ma QY, Côte P,Whiteway M, Jiang YY (2015) The Role of Mms22p in DNA DamageResponse in Candida albicans (2015) G3 (Bethesda). 5, 2567-78. Lu H, Yao XW, Whiteway M, Xiong J, Liao ZB, Jiang YY, Cao YY. (2015) Loss of RPS41gene but not its paralog RPS42 gene results in altered growth, filamentationand transcriptome changes in Candidaalbicans. Fungal Genet Biol. 80, 31-42.