Martin, Vincent - Concordia University

研究领域

Our laboratory views microbes as small "green" factories that can convert simple carbon sources such as CO2, glucose or renewable biomass into bioproducts such as fuels, commodity and specialty chemicals or pharmaceuticals. Using a combination of functional genomics, metabolic engineering and synthetic biology techniques, we study microbes normally found in the environment in order to better understand their metabolism and physiology with the purpose of eventually engineering them as alternatives to producing, cleaner, better, cheaper or even novel products.

近期论文

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Biot-Pelletier,D., V.J.J. Martin. 2016. Seamless and site-directed mutagenesis of the Saccharomycescerevisae genome using CRISPR-Cas9. Journal of Biological Engineering. InPress. Payne, M., L. Narcross, E.Fossati, L. Bourgeois and V.J.J. Martin.2016. Reconstituting plant secondarymetabolism in Saccharomyces cerevisiaefor production of high-value benzylisoquinoline alkaloids. Methods inEnzymology. In Press. Online 10 March 2016 Campbell, A., P.Bauchart, N.D. Gold, Y. Zhu, V. de Luca and V.J.J. Martin. 2016.Engineering of a nepetalactol-producing platform strain of Saccharomycescerevisiae for the production of seco-iridoids. ACS Synthetic Biology. Web PublicationDate: March 16, 2016 Larue, K., M. Melgarand V.J.J. Martin. 2016. Directed evolution of a fungal β-glucosidase in Saccharomyces cerevisiae. Biotechnology for Biofuels. 9:52 Narcross, L, E. Fossati, L. Bourgeois and V J.J. Martin. 2016.Microbial factories for the production of benzylisoquinoline alkaloids. Trendsin Biotechnology. 34:228-241 Hénault-Ethier, L.,T.H. Bell, V.J.J. Martin and Y.Gélinas. 2016. Dynamics of physicochemical variables and cultivable bacteria invermicompost during steady food waste addition and upon feed interruption. CompostScience and Utilization. 24:117–135 Gold, N.D., C.M.Gowan, F.X. Lussier, S.C. Cautha, R. Mahadevan and V.J.J. Martin. 2015. Metabolic engineering of atyrosine-overproducing yeast platform strain evaluated by targetedmetabolomics. Microbial Cell Factories. 14:73 DeLoache, W.C., Z.N. Russ, L. Narcross, A.M.Gonzales, V.J.J. Martin and J.E.Dueber. 2015. An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. Nature ChemicalBiology. 11:465–471 Fossati, E., A. Ekins, L. Narcross, J.-P.Falgueyret and V.J.J. Martin. 2015.Synthesis of morphinan alkaloids in Saccharomycescerevisiae. PLoS One. 10(4). Pinel, D., H.Jiang, D. Colatriano, H. Lee and V.J.J. Martin. 2015. Deconstructing the genetic basis oflignocellulosic hydrolysate tolerance using deep sequencing of genome shuffledyeast. Biotechnology for Biofuels. 8:53 Biot-Pelletier, D. and V.J.J. Martin. 2014. Evolutionaryengineering by genome shuffling. Applied Microbiology and Biotechnology. 98:3877-3887 Fossati, E., A. Ekins, L. Narcross, Y.Zhu, J.-P. Falgueyret, G.A.W. Beaudoin, P.J. Facchini and V.J.J. Martin. 2014. Reconstitution of a 10-gene pathway forsynthesis of the plant benzylisoquinoline alkaloid dihydrosanguinarine in Saccharomycescerevisiae. Nature Communications.Vol 5. Published online Feb 11th. Gawand, P., P.Hyland, A. Ekins, V.J.J. Martin, R.Mahadevan. 2013. Novel approach toengineer strains for simultaneous sugar utilization. Metabolic Engineering. 20:63-72 Mei X., Y. Zhang, X. Chen, E.-J. Lee, C.Barber, R. Chakrabarty, I. Desgagné-Penix, T.M. Haslam, Y-B Kim, E. Liu, G.MacNevin, S. Masada-Atsumi, D. Reed, J.M. Stout, P. Zerbe, Y. Zhang, J.Bohlmann, P.S. Covello, V. De Luca, J.E. Page, D-K Ro, V.J.J Martin, P.J. Facchini,, C. Sensen. 2013. Transcriptome analysis based onnext-generation sequencing of non-model plants producing specializedmetabolites of biotechnological interest. Journal of Biotechnology. 166:122-134 Bajwa, P.K.,C-Y Ho, C-K Chan, V.J.J. Martin, J.T. Trevors and H. Lee. 2013. Transcriptional profiling of Saccharomyces cerevisiae T2 cells upon exposure to hardwood spentsulphite liquor. Antonie van Leeuwenhoek. 103:1281-1295 Cautha, S.C., C.M. Gowen, F.X. Lussier,N.D. Gold, V.J.J. Martin, R.Mahadevan. 2013. Model-driven design of a Saccharomycescerevisiae platform strain with improved tyrosine production capabilities.Computer Applications in Biotechnology 12 (1), 221-226 Lussier, F.X., D. Colatriano, Z.Wiltshire, J.E. Page and V.J.J. Martin.2012. Engineering microbes for plant polyketides biosynthesis. Computationaland Structural Biotechnology Journal for a special volume on Advances inMetabolic Engineering and Design of Cell Factories. Vol.3, Issue 4. Wieczorek, A.S. and V.J.J. Martin. 2012. Effects of cohesin-containing scaffold proteinarchitecture on binding dockerin-enzyme fusions on the surface of Lactococcus lactis. Microbial CellFactories. 11:160. Hagel, J.M., G.Beaudoin, E. Fossati, Ekins, A, V.J.J.Martin and P.J. Facchini. 2012. Characterization of a flavoprotein oxidase fromopium poppy catalyzing the final steps in sanguinarine and papaverinesynthesis. Journal of Biological Chemistry. 51: 42972-42983. Burton, E., and V.J.J. Martin. 2012. Proteomic analysis of Clostridium thermocellum ATCC 27405reveals the up-regulation of an alternative transhydrogenase-malate pathway andnitrogen assimilation during growth on cellulose. Canadian Journal ofMicrobiology. 58:1378-1388. Wilde, C., N. Bawa, N.D. Gold,H. Tambor, L. Mougharbel, R. Storms and V.J.J. Martin. 2012. Expression of a library of fungalß-glucosidases in Saccharomycescerevisiae for the development of a biomass fermenting strain. Applied Microbiology and Biotechnology. 95:647-659 Facchini, P.,J. Bohlmann, P.S. Covello, V. De Luca, R. Mahadevan, J.E. Page, D.-K. Ro, C.W.Sensen. R. Storms, and V.J.J. Martin. 2011. Synthetic biosystems for the productionof high-value plant metabolites. Trends in Biotechnology (Featured on coverpage). 30:127-131 Cluis, C.P., A. Ekins, L. Narcross, H.Jiang, N.D. Gold, A.M. Burja, V.J.J.Martin. 2011 Identification of bottlenecks in Escherichia coli engineered for the production of CoQ10.Metabolic Engineering. 13:733-744. Bajwa, P.K., C. Phaenark, N.Grant, X. Zhang, M. Paice, V.J.J. Martin,J.T. Trevors and H. Lee. 2011. Ethanol production from selectedlignocellulosic hydrolysates by genome shuffled strains of Scheffersomyces stipitis. Bioresource Technology. 102:9965-9969 Usher, J., V. Balderas-Hernandez, P.Quon, N.D. Gold, V.J.J. Martin, R.Mahadevan and K. Baetz. 2011 Chemical and synthetic genetic arrayanalysis identifies genes that suppress xylose utilization and fermentation in Saccharomyces cerevisiae. G3: Genes,Genomes and Genetics. 1:247-258