近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
Kwan, D.H., Jin, Y., Jiang, J., Chen, H.M., Kötzler, M.P., Overkleeft, H.S., Davies, G.J., and Withers, S.G. (2016) "Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases" FEBS Letters, 590, 461-468
Volkers, G. Worral, L.J., Kwan, D.H., Yu. C.-C., Baumann, L., Lameignere, E., Scott, N.E., Wakarchuk, W.W., Foster,L. J., Withers, S.G., and Strynadka, N.C.J. (2015) “Structure of human ST8SiaIII sialyltransferase provides first insights into the molecular detailsof polysialylation of human cell surfaces” Nature Structural and Molecular Biology, 22, 627-635
Kwan, D.H.,Ernst, S., Kötzler, M.P., and Withers, S.G. (2015) “Chemoenzymatic synthesis of a type 2 blood group A tetrasaccharide and the development of high-throughput assays enables a platform for screening blood group antigen-cleaving enzymes” Glycobiology, 25, 806-811
Kwan,D.H., Constantinescu, I., Chapanian, R., Higgins,M.A., Kötzler, M.P., Samain, E., Boraston A.B., Kizhakkedathu, J., and Withers,S.G.* (2015) “Towards efficient enzymes for the generation of universal bloodthrough structure-guided directed evolution”Journal of the American Chemical Society, 137, 5695-5705
Chapanian, R., Kwan, D.H., Constantinescu, I., Shaikh, F.A., Rossi, N.A.A., Withers, S.G., and Kizhakkedathu, J.* (2014) “Enhancement of Biological Reactions on Cell Surfaces via Macromolecular Crowding” Nature Communications, 5, Article number: 4683, DOI: 10.1038/ncomms5683
Kwan, D.H.,and Withers, S.G.* (2014) “Periplasmic de-acylase helps bacteria don their biofilm coat” Proceedings of the National Academy of Sciences of the USA, 111, 10904-10905
Yu, C.-C., Hill, T., Kwan, D.H., Wakarchuk, W.W., Lin, C.-C., and Withers, S.G.* (2014) “A plate based high-throughput activity assay for polysialyltransferase from Neisseria meningitides” Analytical Biochemistry, 444, 67-74
Yu, C.-C., Huang, L.-D., Kwan, D.H.,Wakarchuk, W.W., Withers, S.G., and Lin, C.-C.* (2013) “A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitides” Chemical Communications, 49, 10166-10168
Kwan, D.H.and Withers, S.G.* (2011) “Towards efficient enzymatic glycan synthesis: Directed evolution and enzyme engineering”Journal of Carbohydrate Chemistry, 30,181-205
Kwan, D.H.*and Schulz, F. (2011) “The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases” Molecules, 16, 6092-6115
Kwan, D.H.,Tosin, M., Schläger, N., Schulz, F., and Leadlay, P.F.* (2011) “Insights into the stereospecificity of ketoreduction in a modular polyketide synthase” Organic and Biomolecular Chemistry, 9, 2053-2056
Kwan, D.H.,Chen, H.-M., Ratananikom, K., Hancock, S.M. Watanabe, Y., Kongsaeree, P.T.,Samuels, A.L., and Withers, S.G.* (2011) “Self-immobilizing fluorogenic imaging agents of enzyme activity” Angewandte Chemie International Edition, 50,300-303
Kwan, D.H.*,and Leadlay, P.F. (2010) “Mutagenesis of a modular polyketide synthase enoylreductase domains reveals insights into catalysis and stereospecificity” ACS Chemical Biology, 5, 829-838
Kwan, D.H.,Sun, Y., Schulz, F., Hong, H., Popovic, B., Sim-Stark, C.C., Haydock, S.F., and Leadlay, P.F.* (2008) “Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases” Chemistry and Biology, 15,1231-1240