个人简介

B.S., 1979, University of Missouri - Rolla Ph.D., 1984, Purdue University Postdoctoral Associate, 1986-1987, University of Cincinnati

研究领域

Monitoring Chemistry in Living Organisms

Research is focused on the development of new methods for the study of drug metabolism and disposition. All aspects of the bioanalytical problem of drug disposition studies are being addressed, from sampling of living organisms to analysis of minute biological samples. A major focus is the development of microdialysis sampling in vivo. The research group has provided both novel applications of microdialysis sampling and fundamental studies of the technique. Several novel microdialysis probes have been developed for sampling from peripheral tissue in conscious animals. Studies of drug transport effects on the microdialysis process in vivo have led to greater insight into the use of this technique. Research also involves the development of microanalytical techniques based on separations. On-column sample concentration methods, electrochemical detectors and mass spectrometer interfaces for capillary electrophoresis (CE) are being developed. These microanalytical techniques are being directly coupled to microdialysis sampling to provide separation-based in vivo sensors. These systems provide near real-time monitoring of multiple chemical species in the tissues of awake freely-moving animals. These new bioanalytical tools are being applied to several important problems in drug metabolism and disposition studies. Some current projects include studying the neuropharmacology of drugs to fight addiction, a study on the adsorption of pharmaceuticals in healthy and ulcerated stomachs, an investigation of the transdermal delivery of therapeutic agents, and approaches to inhibiting epileptic seizures. The group has recently embarked on a new project to develop analytical methods to detect biomarkers for oxidative DNA damage and lipid peroxidation occurring as a result of oxidative stress during heart attack and stroke. These methods will then be used with microdialysis sampling in the heart and brain to study the affects of oxidative stress during heart attack and stroke.

近期论文

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Investigation of microdialysis sampling calibration approaches for lipophilic analytes: Doxorubicin Whitaker, G., Lunte, C. E., . J Pharm Biomed Anal.(2010), 53(3), 490-496. LC-MS/MS determination of carbamathione in microdialysis samples from rat brain and plasma. Kaul S, Williams TD, Lunte CE, Faiman MD., J Pharm Biomed Anal. (2010), 51(1), 186-191. CE-LIF method for the separation of anthracyclines: application to protein binding analysis in plasma using ultrafiltration. Whitaker, Gillian; Lillquist, Amy; Pasas, Stephanie A.; O'Connor, Robert; Regan, Fiona; Lunte, Craig E.; Smyth, Malcolm R. Journal of Separation Science (2008), 31(10), 1828-1833. The development of multiple probe microdialysis sampling in the stomach. Woo, Kristin L.; Lunte, Craig E. Journal of Pharmaceutical and Biomedical Analysis (2008), 48(1), 20-26. The direct comparison of health and ulcerated stomach tissue: A multiple probe microdialysis sampling approach. Journal of Pharmaceutical and Biomedical Analysis. Woo, Kristin L.; Lunte, Craig E. Journal of Pharmaceutical and Biomedical Analysis (2008), 48(1), 85-91. Development of tissue-targeted metabonomics. Part 1. Analytical considerations. Price, K. E.; Lunte, C. E.; Larive, C. K. Journal of Pharmaceutical and Biomedical Analysis (2008), 46(4), 737-747. Investigation of drug delivery by iontophoresis in a surgical wound utilizing microdialysis. Holovics, H. J.; Anderson, C. R.; Levine, B. S.; Lunte, C. Pharmaceutical Research (2008), 25(8), 1762-1770.