English, Ann - Concordia University - Department of Chemistry & Biochemistry

研究领域

Analytical, Biophysical, Proteomics, Bioinorganic, Mass Spectrometry.

近期论文

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M.Kathiresan and A.M. English (2017) LC-MS/MS reveals that hole hopping incytochrome c peroxidase protects its heme from oxidative modification by excessH2O2, Chemical Science, 8, 1152-1162. DOI: 10.1039/C6SC03125K P. Ponka, A.D. Sheftel, A.M. English, D.S. Bohle, and D.Garcia-Santosa (2017), Do mammalian cells really need to export andimport heme? Trends in Biochemical Sciences, in press. E. Orabi and A.M. English (2016) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Bindingto Tyrosinate and Histidinium Ions to Assess Their Influence on ProteinElectron Transfer, Isr. J. Chem. 56, 872-885 (Festschrift for H.B. Gray). DOI:10.1002/ijch.201600047 M. Kathiresan and A.M. English (2016) Targeted proteomics identifymetabolism-dependent interactors of yeast cytochrome c peroxidase: Implicationsin stress response and heme trafficking, Metallomics 8, 434 – 443. M.S. Shadrina, A.M. Englishand G.H. Peslherbe (2016) BenchmarkingRapid TLES Simulations of Gas Diffusion in Proteins: Mapping O2Migration and Escape in Myoglobin as a Case Study, J. Chem. Theory Comput. 12, 2038−2046. M.S. Shadrina, G.H. Peslherbe andA.M. English (2015) Quaternary-linkedchanges in structure and dynamics that modulate O2 migration withinhemoglobin’s gas diffusion tunnels, Biochemistry 54, 5268-5278. M.S.Shadrina, G.H. Peslherbe and A.M. English (2015) O2 and water migration pathways between thesolvent and heme pockets of hemoglobin with open and closed conformations ofthe distal HisE7, Biochemistry, 54,5279–5289. D. Martins and A.M. English (2015) Peroxynitrite andhydrogen peroxide elicit a similar cellular stress response mediated by theCcp1 sensor protein,Free Rad. Biol. Med. 85,138-147. M. Kathiresan, D. Martins and A.M. English (2014) Respiration triggers heme transfer from cytochrome cperoxidase to catalase in yeast mitochondria, Proc.Nat. Acad. Sci, USA 111, 17468–17473. D. Martins and A.M. English (2014) Sod1 oxidationand formation of soluble aggregates in yeast: relevance to sporadic ALSdevelopment,Redox Biology 2, 632-639. D. Martins, V.I. Titorenko and A.M. English (2014) Cells with impaired mitochondrial H2O2 sensinggenerate less •OH radicals and live longer, Antiox. Red. Sig. 21, 1490-1503. D. Martins and A.M. English (2014) Catalase activity is stimulatedby H2O2 inrich culture medium and is required forH2O2 resistance and adaptation in yeast, Redox Biology 2,308-313. B. Shen, C. Bazin, and A.MEnglish (2013) Rapid high-yield N-acetylation of aminothiols: N-acetylglutathione andN-acetylhomocysteine and their thiol pKa values, J. Peptide Science 19, 263–267. Clarke, M. Ouellet, and A.M.English (2013) Overcoming matrix effects in the chemiluminescence determination ofextracellular adenosine triphosphate in erythrocyte suspensions, Anal.Biochem. 436, 66-68. M. Khakimova, H. G. Ahlgren,J.J. Harrison, A.M. English and D. Nguyen (2013)The stringent response controls catalasesin Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance, J. Bacteriology 195, 2011-2020. D. Martins, M. Kathiresan andA.M. English (2013) Cytochrome c peroxidase (Ccp1) is amitochondrial heme-based H2O2 sensor that modulatesantioxidant defense, Free Rad. Biol. Med. 65, 541-551. A.B. Seabra, M. Ouellet, M.Antonic, M.N. Chrétien, and A.M. English (2013)Catalysis of nitrite generation fromnitroglycerin by glyceraldehyde-3-phosphate dehydrogenase (GAPDH), NitricOxide 35, 116–122. M.S. Shadrina, A.M. English andG.H. Peslherbe (2012) Effective simulations of gas diffusionthrough kinetically accessible tunnels in multi-subunit proteins: O2pathways and escape routes in T-state deoxyhemoglobin, J. Am. Chem. Soc. 134, 11177−11184. D.Susanto A.M. English, R. Sharmaand E. Kwong (2011) An alternative approach using ESI-MS toiron quantitation in pharmaceutical formulations containing iron oxide, J. Mass Spec. 46, 508–516. E.E.Moran, Q.K. Timerghazin, E. Kwong and A.M. English (2011)Kinetics and mechanism of S‑nitrosothiol acid-catalyzed hydrolysis: Sulfuractivation promotes facile NO release, J. Phys. Chem. B 115,3112–3126. J.I. Garcia, A.B. Seabra, R. Kennedy andA.M. English (2010) Nitrite and nitroglycerin inducerapid release of the vasodilator ATP from erythrocytes: Relevance to thechemical physiology of local vasodilation J. Inorg. Biochem. 104, 289-296. A.A.Goldberg, V.R. Richard, P. Kyryakov, S.D. Bourque, A. Beach, M.T. Burstein, A.Glebov, O. Koupaki, T. Boukh-Viner, C. Gregg, M. Juneau, A.M. English, D.Y.Thomas and V.I. Titorenko (2010) Chemical genetic screen identifieslithocholic acid as an anti-aging compound that extends yeast chronologicallife span in a TOR-independent manner, by modulating housekeeping longevityassurance processes, Aging 2, 393-414. Q.K. Timerghazin, G.H.Peslherbe and A.M. English (2008) Structure andstability of HSNO, thesimplest S-nitrosothiol, Phys. Chem. Chem. Phys. 10, 1532-1539. Q.K.Timerghazin, A.M. English and G.H. Peslherbe (2008) On the multireference characterof S-nitrosothiols, Chem.Phys. Letts. 454, 24-29. Q.K. Timerghazin, G.H. Peslherbe andA.M. English (2007) Resonance description of S-nitrosothiols:Insights into reactivity, Org. Letts.9, 3049-3052.