个人简介

B.A. 1985, Luther College Ph.D., 1993, University of Minnesota National Institutes of Health Postdoctoral Fellow, 1993-1996, Stanford University

研究领域

Synthetic methods/natural product synthesis/transition metal-catalyzed methods/asymmetric methods/S- and P-heterocycles/immobilized reagent development/drug discovery and delivery/and chemical methods for library development.

The major goal of our research program is the development of new synthetic methods for use in drug discovery and natural product synthesis. In particular, we have focused our attention on the utilization of transition metal-catalyzed methods as a means to produce new heterocycles containing sulfur and phosphorus (S- and P-heterocycles) that exhibit both biological and synthetic utility. Central to this goal is the development of phosphorus tethered processes in the synthesis of complex, biologically relevant natural products. Another facet of our program is aimed at the development of immobilized reagents for use in drug discovery. We are currently employing ring-opening metathesis (ROM) polymerization to generate high-load oligomers with tuneable properties as tools for organic synthesis and library production. We have a long-standing interest in the establishing new chemical methods for library development.

近期论文

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Rolfe, A.; Young, K.; Volp, K.; Schoenen, F.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. A One-Pot, 3-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1,2-benzisothiazoline-3-acetic acids. J. Comb. Chem. 2009, 11, 732-738. Thomas, C. D.; McParland, J. P.; Hanson, P. R. Divalent and Multivalent Activation in Phosphate Triesters: A Versatile Method for the Synthesis of Advanced Polyol Syntons. Eur. J. Org. Chem. 2009, In Press. Thomas, C. D.; Hanson, P. R. Phosphorus and Sulfur Heterocycles via Ring-Closing Metathesis: Application in Natural Product Synthesis. Metathesis in Natural Product Synthesis. (J. Cossy, C. Meyer, Eds), Wiley-VCH: Weinheim, Germany, 2009, In Press. Jeon, K.; Rayabarapu, D.; Rolfe, A.; Volp, K.; Omar, I.; Hanson, P. R. Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams Tetrahedron 2009, 65, 4992-5000. Dinesh Kumar Rayabarapu, Aihua Zhou, Kyu Ok Jeon, Thiwanka Samarakoon, Alan Rolfe, Hina Siddiqui, Paul R. Hanson α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams Tetrahedron 2009, 65, 3180-3188. Rolfe, A.; Young, K.; Hanson, P. R. Domino Heck-Aza-Michael Reactions: A One-pot, Multi-Component Approach to 1,2-benzisothiazoline-3-acetic acid 1,1-dioxides. Eur. J. Org. Chem. 2008,5254-5262. Zhou, A.; Rayabarapu, D.; Hanson, P. R. “Click, Click, Cyclize”: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins. Org. Lett. 2009, 11, 531-534. Rolfe, A.; Probst, D.; Volp, K.; Omar, I.; Flynn, D.; Hanson, P. R. High-load, Oligomeric dichlorotriazine (ODCT): A Versatile ROMP-derived Reagent and Scavenger. J. Org. Chem. 2008, 73, 8785-8790. Zhou, A.; Hanson, P. R. Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reactions. Org. Lett. 2008, 10, 2951-2954. Hanson, P. R.; Samarakoon, T.; Rolfe, A. Supported/Tagged Scavengers for Facilitating High-throughput Chemistry. In The Power of Functional Resins in Organic Synthesis. (F. Albericio, J. Tulla-Puche, Eds), Wiley-VCH: Weinheim, Germany, 2008, pp 183-223. Stoianova, D. S.; Yao, L.; Rolfe, A.; Samarakoon, T.; Hanson, P. R. High-load, oligomeric monoamine hydrochloride: Facile generation via ROM polymerization and application as an electrophile scavenger. Tetrahedron Lett. 2008, 49, 4553-4555. Whitehead, A.; Waetzig, J. D.; Thomas, C. D.; Hanson, P. R. A Multifaceted Phosphate Tether: Application to the C15-C30 Subunit of Dolabelides A-D. Org. Lett. 2008, 10, 1421-1424. PMID 18324822 Jiménez-Hopkins, M.; Hanson, P. R. An RCM Strategy to Stereodiverse d-Sultam Scaffolds. Org. Lett. 2008, 10, 2223-2226. Waetzig, J. D.; Hanson, P. R. A Multifaceted Phosphate Tether: Application to the C1-C14 Subunit of Dolabelides A-D. Org. Lett. 2008, 10, 109-112. PMID 18062695