个人简介

B.A., 1997, Grinnell College Ph.D., 2001, University of California-Berkeley

研究领域

Mass Spectrometry: Bioanalytical and Physical Organic Applications

We apply our core competencies, mass spectrometry and machine learning, to develop tools and biomarkers that will improve human health and address health disparities in underserved populations.

近期论文

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Lakbub JC, Shipman JT, Desaire H. Recent mass spectrometry-based techniques and considerations for disulfide bond characterization in proteins. Anal. Bioanal. Chem., 410(10), 2467-2484 (2018). Go EP, Moon HJ, Mure M, Desaire H. Recombinant human Lysyl Oxidase-Like 2 secreted from human embryonic kidney cells displays complex and acidic glycans at all three N-linked glycosylation sites. J. Proteome Resch., 17(5), 1826-1832 (2018). Hua D, Patabandige MW, Go EP, Desaire, H. The Aristotle Classifier: Using the Whole Glycomic Profile To Indicate a Disease State. Anal. Chem., 91(17), 11070-11077 (2019). Shipman JT, Nguyen H, Desaire H. So you discovered a potential glycan-based biomarker; now what? We developed a high-throughput method for quantitative clinical glycan biomarker validation. ACS Omega 5(12), 6270-6276(2020). Hua D, Liu X, Go EP, Wang Y, Hummon AB, Desaire H. How to apply supervised machine learning tools to MS imaging files: Case study with cancer spheroids undergoing treatment with the monoclonal antibody Cetuximab. J. Am. Soc. Mass Spectrom. 31(7), 1350-1357 (2020). Patabandige MW, Go EP, Desaire H. Clinically viable assay for monitoring Uromodulin glycosylation. J. Am. Soc. Mass Spectrom. 32(2), 436-443 (2021). Khan MJ, Desaire H, Lopez OL, Kambosh MI, Robinson RAS. Why inclusion matters for Alzheimer's disease biomarker discovery in plasma. J Alzheimers Dis. 79(3), 1327-1344 (2021). Patabandige MW, Pfeifer LD, Nguyen HT, Desaire H. Quantitative clinical glycomics strategies: A guide for selecting the best analysis approach. Mass Spec. Rev. (2021). DOI: 10.1002/mas.21688 Go EP, Zhang S, Ding H, Kappes JC, Sodroski JG, Desaire H. The opportunity cost of automated glycopeptide analysis: case study profiling the SARS-CoV-2 S glycoprotein. Anal. Bioanal. Chem. 413 (29), 7215-7227 (2021). Desaire H, Stepler KE, Robinson RAS. Exposing the brain proteomic signatures of Alzheimer’s disease in diverse racial groups: Leveraging multiple datasets and machine learning. J. Proteome Resch. 21(4), 1095–1104 (2022). Meier AA, Go EP, Moon HJ, Desaire H, Mure M. Mass spectrometry-based disulfide mapping of human lysyl oxidase-like 2. Int. J. Mol. Sci.23(11), 5879 (2022). Pfeifer LD, Patabandige MW, Desaire H. Leveraging R (LevR) for Fast Processing of Mass Spectrometry Data and Machine Learning: Applications Analyzing Fingerprints and Glycopeptides. Front. Anal. Sci. (2022). DOI: 10.3389/frans.,2022.961592 Desaire H. How (Not) to Generate a Highly Predictive Biomarker Panel Using Machine Learning. J. Proteome Resch. 21 (9), 2071-2074. (2022). Desaire H, Go EP, Hua D. Advances, obstacles, and opportunities for machine learning in proteomics. Cell Reports Phys. Sci. 101069 (2022).