个人简介

B.S. Western Michigan University, 2005 Ph.D. Northwestern University, 2010 Postdoctoral Associate, Princeton University, 2010-2013

研究领域

Organic Chemistry/Asymmetric Catalysis/Total Synthesis of Natural Products

Research in the Clift group focuses heavily on the development of new catalytic methods for organic synthesis. In biological systems, enzymatic cofactors display a seemingly limitless array of powerful organic reactivity. By harnessing the potential of these unique organic molecules in abiotic environments, we seek to discover novel synthetic strategies that will enable a diverse range of enantioselective transformations. Specifically, we are interested in the development of new organocatalytic reaction manifolds that will enable a variety of C−C bond forming events through inert bond functionalization. The successful pursuit of these goals is expected to deliver synthetic methods that will facilitate previously challenging or even impossible chemical transformations. In a broader context, this work will ultimately accelerate the construction of biologically relevant natural products and other medicinal agents by providing new means for the strategic disconnection of these valuable synthetic targets.

近期论文

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Direct beta-Alkylation of Aldehydes via Photoredox Organocatalysis. Terrett, J. A.; Clift, M. D.; MacMillan, D. W. C. J. Am. Chem. Soc. manuscript in press (ASAP). Oxidative Coupling of Enolates, Enol Silanes and Enamines: Methods and Natural Product Synthesis. Guo, F.; Clift, M. D.; Thomson, R. J. Eur. J. Org. Chem. 2012, 4881–4896. Total Synthesis of the Galbulimima Alkaloid (−)-GB17. Larson, R. T.; Clift, M. D.; Thomson, R. J. Angew. Chem. Int. Ed. Engl. 2012, 51, 2481–2484. Enantioselective Total Synthesis and Confirmation of the Absolute and Relative Stereochemistry of Streptorubin B, Hu, D. X.; Clift, M. D. and Thomson, R. J. J. Am. Chem. Soc. 2011, 133, 1799–1804. Development of a Merged Conjugate Addition/Oxidative Coupling Sequence. Application to the Enantioselective Total Synthesis of Metacycloprodigiosin and Prodigiosin R1, Clift, M. D. and Thomson, R. J. J. Am. Chem. Soc. 2009, 131, 14579–14583. Oxidative Carbon–Carbon Bond Formation via Silyl Bis-enol Ethers: Controlled Cross-coupling for the Synthesis of Quaternary Centers, Clift, M. D.; Taylor, C. N.; Thomson, R. J. Org. Lett. 2007, 9, 4667–4669. Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ-Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding, Clift, M. D.; Ji, H.; Deniau, G. P.; O’Hagan, D.; Silverman, R. B. Biochemistry 2007, 46, 13819–13828. Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase, Clift, M. D.; Silverman, R. B. Bioorg. Med. Chem. Lett. 2007, 18 (10), 3122–3125.