Suh, Se Won - Seoul National University

个人简介

Education B.S. Chemistry, Seoul National University, Korea, 1973 M.S. Chemistry, Seoul National University, Korea, 1975 Ph.D. Chemistry and Biochemistry, University of California, Los Angeles, USA, 1980 Research Experiences Visiting Fellow, National Institutes of Health, USA, 1980-1982 Visiting Professor, in Department of Chemistry and Biochemistry, University of California, Los Angeles, USA, 1986-1987

研究领域

BIO

Current Research Interests The goal of our structural biology research in my laboratory is to understand how the proteins and enzymes work at the atomic level by determining their three-dimensional structures. Elucidation of protein structures is essential in revealing the structure-function relationship as well as in designing enzyme inhibitors as drug lead compounds and in discovering useful biocatalysts for industrial purposes. The main tools used in my laboratory are molecular biology/biochemistry and X-ray crystallography. Our current research interests include the following areas. 1. Structural proteomics on proteins from pathogenic microorganisms and human 2. Structure determination of highly thermostable proteins

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Kim, K. H., An, D. R., Song, J., Yoon, J. Y., Kim, H. S., Yoon, H. J., Im, H. N., Kim, J., Kim, D. J., Lee, S. J., Kim, K.-H., Lee, H.-M., Kim, H.-J., Jo, E.-K., Lee, J. Y., and Suh, S. W. (2012), "Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7," Proc. Natl. Acad. Sci. USA in press Yoon, J. Y., Park, C. R., Lee, H. H., and Suh, S. W. (2012), "Overexpression, crystallization and preliminary X-ray crystallographic analysis of pyridoxal biosynthesis lyase PdxS from Pyrococcus horikoshii," Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(4), 440-442. (IUCr) Han, B. G., Kim, K. H., Lee, S. J., Jeong, K. C., Cho, J. W., Noh, K. H., Kim, T. W., Kim, S. J., Yoon, H. J., Suh, S. W., Lee, S., and Lee, B. I. (February 12, 2012), "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules," J. Biol. Chem. (Elsevier) Yoon, J. Y., Kim, J., Lee, S. J., Kim, H. S., Im, H. N., Yoon, H. J., Kim, K. H,, Kim, S. J., Han, B. W., and Suh, S. W. (2011), "Structural and functional characterization of Helicobacter pylori DsbG," FEBS Lett. 585(24), 3862-3867. (FEBS) Yoon, H. J., Kang, J. Y., Mikami, B., Lee, H. H., and Suh, S. W. (2011), “Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine,” Mol Cells. 32(5), 431-435. (KSMCB) Kim, K. H., Kang, W. C., Suh, S. W., and Yang, J. K. (2011), "Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain" Proteins 79(8), 2583-2587. (Wiley-Liss, Inc.) Kim, H. S., Lee, S. J., Yoon, H. J., An, D. R., Kim, D. J., Kim, S. J., and Suh, S. W. (September, 2011), “Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases,” J. Struct. Biol. 175(3), 442-450. (Elsevier) Lee, S. J., Kim, D. J., Kim, H. S., Lee, B. I., Yoon, H.-J., Yoon, J. Y., Kim, K. H., Jang, J. Y., Im, H. N., An, D. R., Song, J.-S., Kim, H.-J., and Suh, S. W. (2011), "Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily," J. Struct. Biol. 175(3), 329-338. (Elsevier) Lee, S. J., Lee, B. I., and Suh, S. W. (2011) “Crystal structure of the catalytic domain of cholesterol-メ-glucosyltransferase from Helicobacter pylori,” Proteins 79(7), 2321-2326. (Wiley-Liss, Inc.) Lee, S. J. Kim, H. S., Kim, D. J., Yoon, H. J., Kim, K. H., Yoon, J. Y. and Suh, S. W. (2011) "Crystal structures of LacD from Staphylococcus aureus and LacD.1 from Streptococcus pyogenes: insights into substrate specificity and virulence gene regulation," FEBS Lett. 585(2), 307-312. (Fed. European Biochem. Soc.) Kim, D. J., Park, K. S., Kim, J. H., Yang, S. H, Yoon, J. Y., Han, B. G., Kim, H. S., Lee, S. J., Jang, J. Y., Kim, K. H., Kim, M. J., Song, J. S., Kim, H. J., Park, C. M., Lee, S. K., Lee, B. I., and Suh, S. W. (2010), "Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase," Proc. Natl. Acad. Sci. USA 107(50), 21418-21423. Kim, S. J., Ha, B. H., Kim, K. H., Hong, S. K., Shin, K. J., Suh, S. W., and Kim, E. E. (2010), "Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus," Biochem. Biophys. Res. Commun. 400(4), 517-522. Lee, H. H., Yoon, H. J., Kim, S. J., and Suh, S. W. (2010), “Crystal structures of two archaeal Pelotas reveal inter-domain structural plasticity,” Biochem. Biophys. Res. Commun. 399(4), 600-606. (Academic Press) Lee, S. K., Choi, K. H., Lee, S. J., Suh, S. W., Kim, B. M., and Lee, B. J. (2010), "Peptide deformylase inhibitors with retro-amide scaffold: Synthesis and structure-activity relationships," Bioorg. Med. Chem. Lett. 20(15), 4317-4319. Lee, H. H. and Suh, S. W. (2010), "Overexpression, crystallization, and preliminary X-ray crystallographic analysis of Pseudomonas aeruginosa MnmE, a GTPase involved in tRNA modification," Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66(8), 905-908. (International Union of Crystallography) Seo, J. H., Cha, J. H., Park, J. H., Jeong, C. H., Park, Z. Y., Lee, H. S., Oh, S. H., Kang, J. H., Suh, S. W., Kim, K. H., Ha, J. Y., Han, S, H., Kim, S. H., Lee, J. W., Park, J. A., Jeong, J. W., Lee, K. J., Oh, G. T., Lee, M. N., Kwon, S. W,, Lee, S. K., Chun, K. H,, Lee, S. J., Kim, K. W. (2010), “Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation," Cancer Res. 70(11), 4422-4432. (American Association for Cancer Research) (Epub 2010 May 25) Kim, H., Choi, J., Kim, T., Lokanath, N. K., Ha, S. C., Suh, S. W., Hwang, H. Y., and Kim, K. K. (2010), "Structural basis for the reaction mechanism of UDP-glucose pyrophosphorylase," Mol. Cells 29(4), 397-405. (Korean Society for Molecular and Cellular Biology) Kim, H. S., Kim, H. L., Kim, K. H., Kim, D. J., Lee, S. J., Yoon, J. Y., Yoon, H. J., Lee, H. Y., Park, S. B., Kim, S.-J., Lee, J. Y., and Suh, S. W. (2010), "Crystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex," Nucleic Acids Res. 38(6), 2099-2110 (Oxford University Press) Jin, B. S., Han, S. G., Lee, W. K., Ryoo, S. W., Lee, S. J., Suh, S. W., and Yu, Y. G. (2009), "Inhibitory mechanism of novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae," J. Microbiol. Biotechnol. 19(12), 1582-1589. (Korean Society for Microbiology and Biotechnology) Lee, H. H., Yoon, H. J., Kang, J. Y., Park, J. H., Kim, D. J., Choi, K.-H., Lee, S.-K., Song, J., Kim, H.-J., and Suh, S. W. (2009), "Crystal structure of Staphylococcus aureus phosphopantetheine adenylyltransferase in complex with 3'-phosphoadenosine 5'-phosphosulfate reveals a new ligand binding mode," Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(10), 987-991. (International Union of Crystallography)