Brunetti, Craig - Trent University - Department of Biology

研究领域

The study of viral immune modulation strategies has increased our understanding of the diverse array of mechanisms that viruses use to circumvent the host immune response as well as providing a greater understanding of host immune function. In particular, the large DNA viruses, such as the Herpesviridae and Poxviridae families encode an array of viral proteins that subvert immune system function at many different levels. Although many immune evasion genes have been identified, the cellular targets of these virulence factors are often specific to a particular virus or viral family. Our laboratory is using a scientifically unexploited family of large DNA viruses, the Iridoviridae, to identify new viral immune evasion strategies. Identifying viral immune evasion genes from the Iridoviridae family will help identify new cellular anti-viral pathways that are not targeted by other viral families as well as providing greater insight into the function of previously identified cellular anti-viral responses.

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Lacerda, A.F., E. Hartjes, and C.R. Brunetti (2014). LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS One 9(7):e103454 Morrison, E.A., S. Garner, P. Echaubard, D. Lesbarreres, C.J. Kyle, and C.R. Brunetti (2014). Complete genome analysis of a frog virus 3 (FV3) isolate and sequence comparison with isolates of differing levels of virulence. Virology Journal 11(1):46. Ring, BA, A. Ferreira Lacerda, D.J. Drummond, C. Wangen, H.E. Eaton, and C.R. Brunetti (2013). Frog virus 3 open reading frame 97R localizes ot the endoplasmic reticulum and induces nuclear invaginations. J. Virol. 87(16):9199-9207. Eaton, H.E, A.F. Lacerda, G. Desrochers, J. Metcalf, A. Angers, and C.R. Brunetti (2013). Cellular LITAF interacts with frog virus 3 - 75L and alters its subcellular localization. Journal of Virology J. Virol. 87(2):716-723. Eaton, H.E., J. Metcalf, A.F. Lacerda, and C.R. Brunetti (2012). Accumulation of endogenous LITAF in aggresomes. PLoS One 7(1):e30003. Eaton, H.E., G. Desrochers, S.B. Drory, J. Metcalf, A. Angers, and C.R. Brunetti (2011). SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase Itch towards the lysosomal compartments. PLoS One 6(2):e16873. Eaton, H.E., B. Ring, and C.R. Brunetti (2010). The evolution and diversity of the Iridoviridae. Viruses 2:1458. Eaton, H.E., E. Penny, and C.R. Brunetti (2010). Antibody dependent enhancement of frog virus 3 infection. Virology Journal 7:41. Eaton, H.E., J. Metcalf, and C.R. Brunetti (2008). Expression of frog virus 3 genes is impaired in mammalian cell lines. Virology Journal 5: 83 Eaton, H.E., J. Metcalf, and C.R. Brunetti (2008). Characterization of the promoter activity of a poxvirus conserved element. Can. J. Microbiol 54:483-488 Nazarian S.H., M.M Rahman, S.J. Werden, D. Villeneuve, X. Meng, C. Brunetti, C. Valeriano, C. Wong, R. Singh, J.W. Barrett, Y. Xiang, and G. McFadden (2008). Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18. J. Virology 82: 522-528 Duffus, A.L.J., B.D. Pauli, K. Wozney, C.R. Brunetti, and M. Berrill (2008). Frog virus 3-like infections in aquatic amphibian communities. Journal of Wildlife Diseases 44:109-120 Eaton, H.E., J. Metcalf, E. Penny, V. Tcherepanov, C. Upton, and C.R. Brunetti (2007). Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes. Virology Journal 4: 11 Barrett, J.W., Y. Sun, S.H. Nazarian, T.A. Belsito, C.R. Brunetti, and G. McFadden (2006). Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells. Virus Genes 33:15-26 Lewis, D.L. and C.R. Brunetti (2006). Ectopic transgene expression in butterfly imaginal wing discs using vaccinia virus. Biotechniques 40: 48-54 Brunetti, C.R., H. Amano, Y. Ueda, J. Qin, T. Miyamura, T. Suzuki, X. Li, J.W. Barrett, and G. McFadden (2003). The complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. Journal of Virology 77: 13335-13347 Seet, B.T., C.A. McCaughan, T.M. Handel, A. Mercer, C. Brunetti, G. McFadden, and S.B. Fleming (2003). Analysis of an orf virus chemokine- binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proceeding of the National Academy of Sciences USA 100:15137-15142 Brunetti, C.R., M. Paulose-Murphy, R. Singh, J. Qin, J.W. Barrett, A. Tardivel, P. Schneider, K. Essani, and G. McFadden (2003). A high affinity inhibitor of human TNF from Tanapox virus. Proceedings of the National Academy of Sciences USA, 100:4831-4836 Seet, B.T., J.B. Johnson, C.R. Brunetti, J.W. Barrett, H. Everett, C. Cameron, J. Sypula, S. Nazarian, A. Lucas, and G. McFadden (2003). Poxviruses and immune evasion. Annual Reviews of Immunology, 21: 377-423