个人简介

Education B.S. Chemistry, Seoul National University, Korea, 1993 M.S. Chemistry, University of Chicago, USA, 1995 Ph.D. Chemistry, University of Chicago, USA, 1998 Research Experiences Research Associate, University of Chicago, 1999 Research Associate, Massachusetts Institute of Technology, 2000 Research Associate, University of California, San Francisco, 2000-2004

研究领域

PHYS/THEO

Current Research Interests Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.

近期论文

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H. S. Lee, C. Seok, and W. Im*, Potential Application of Alchemical Free Energy Simulations to Discriminate GPCR Ligand Efficacy, J. Chem. Theo. Comput. accepted (2015). H. Park, G. R. Lee, L. Heo, and C. Seok*, Protein loop modeling using a new hybrid energy function and its application to modeling in inaccurate structural environments, PLoS ONE 9(11): e113811 (2014). L. Heo, W. -H. Shin, M. S. Lee, and C. Seok*, GalaxySite: Ligand-binding site prediction by using molecular docking, Nucleic Acids Res. 42 (W1), W210-W214 (2014). W. -H. Shin, G. R. Lee, L. Heo, H. Lee, and C. Seok*, Prediction of Protein Structure and Interaction by GALAXY protein modeling programs, Bio Design, 2 (1), 1-11 (2014). Y. Kim, H. Lee, L. Heo, C. Seok, and J. Choe*, Structure of Vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif, Protein Science, 23 (7), 906-914 (2014). M. F. Lensink et al. (H, Park, J. Ko, H. Lee, C. Seok), Blind prediction of interfacial water positions in CAPRI, Proteins: Structure, Function, and Bioinformatics, 82 (4), 620-632 (2014). W. -H. Shin, J. -K. Kim, D. -S. Kim*, and C. Seok*, GalaxyDock2: Protein-ligand docking using beta-complex and global optimization, J. Comput. Chem. 34 (30), 2647-2656 (2013). (Inside cover article) R. Moretti et al. (H. Lee, H, Park, C. Seok), Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions, Proteins: Structure, Function, and Bioinformatics, accepted (2013). Y. Kim, S. Shin, T. Kim, D. Lee, C. Seok, and M. Lee*, Switchable nanoporous sheets by the aqueous self-assembly of aromatic macrobicycles, Angew. Chem. Int. Ed., 52 (25), 6426-6429 (2013). L. Heo, H. Park, and C. Seok*, GalaxyRefine: Protein structure refinement driven by side-chain repacking, Nucleic Acids Res. 41 (W1), W384-W388 (2013). L. Heo, Y.-B. Cho, M. S. Lee, J.-H. Roe*, and C. Seok*, Alternative zinc-binding sites explain the redox sensitivity of zinc-containing anti-sigma factors, Proteins: Structure, Function, and Bioinformatics, 81 (9), 1644-1652 (2013). M.-S. Kim, H. Lee, A. Lim, L. Heo, C. Seok*, and D. H. Shin*, New molecular interaction of IIANtr and HPr from Burkholderia pseudomallei identified by X-ray crystallography and docking studies, Proteins: Structure, Function, and Bioinformatics, 81 (9), 1499-1508 (2013). D. Lee, J. Lee, and C. Seok*, What stabilizes close arginine pairing in proteins?, Phys. Chem. Chem. Phys., 15 (16), 5844-5853 (2013). H. Lee, H. Park, J. Ko, and C. Seok*, GalaxyGemini: a web server for protein homo-oligomer structure prediction based on similarity, Bioinformatics, 29 (8), 1078-1080 (2013). W. -H. Shin and C. Seok*, GalaxyDock: Protein-ligand docking with flexible protein side-chains, J. Chem. Inf. Model, 52 (12), 3225-3232 (2012). Z. Huang, S. -K. Kang, M. Banno, T. Yanaguchi, D. Lee, C. Seok, E. Yashima, and M. Lee*, Pulsating tubules from noncovalent macrocyles, Science, 337 (6101), 1521-1526 (2012). Y.-K. Lee, J. Lee, J. H. Choi, and C. Seok*, Contribution of counterion entropy to the salt-induced transition between B-DNA and Z-DNA, Bull. Korean Chem. Soc. 33, 3719-3726 (2012). J. Ko, H. Park, and C. Seok*, GalaxyTBM: template-based modeling by building a reliable core and refining unreliable local regions, BMC Bioinformatics, 13, 198 (2012). J. Ko, H. Park, L. Heo, and C. Seok*, GalaxyWEB server for protein structure prediction and refinement, Nucleic Acids Res. 40 (W1), W294-W297 (2012). H. Park and C. Seok*, Refinement of unreliable local regions in template-based protein models, Proteins: Structure, Function, and Bioinformatics, 80 (8), 1974-1986 (2012).