个人简介
Education and Experience
B.S. Chemistry, Yonsei University, Korea, 1993
M.S. Chemistry, Yonsei University, Korea, 1997
Ph.D. Chemistry, Texas A&M University, USA, 2001
Research Experiences
Postdoctoral Research Fellow, Harvard University, 2001-2004
近期论文
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Deconvolution of Specific and Nonspecific Protein Targets using Proteome-Labeling Profiles of Photoaffinity Linkers. Park, J.; Koh, M.; Koo, J. Y.; Lee, S.; Park, S.B.* submitted.
Unique Photophysical Properties of 9-Styryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one and Their Efficient Synthesis via Direct C-H Activation. Choi, E.; Park, S.B.* Chemical Science 2015 in revision.
Nuclear Receptor ERRg Regulates Alcohol-Induced Oxidative Stress through Induction of CYP2E1. Lee, J. H.; Kim, E.-J.; Kim, D.-K.; Lee, J.-M.; Park, S.B.; Lee, I.-K.; Harris, R. A.; Lee, M.-O.*; Choi, H.-S.* PLoS ONE 2015 in revision. (IF: 3.730)
Discovery of In Vivo Effective Anti-virulence Agent of Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR from Phenotype-Based Elastase Inhibitor Screening. Kim, S.M.; Park, J.; Kim, B.; Kim, M.S.; Song, H.; Jo, A.; Park, H.; Kim, T.S.*; Choi, S.H.*; Park, S. B.* 2015 submitted
Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Kim, J.I.; Huh, J.Y.; Sohn, J.H.; Choe, S.S.; Lee, Y.S.; Lim, C.Y.; Jo, A.; Park, S.B.; Han, W.; Kim, J.B. Mol. Cell. Biol. 2015, doi:10.1128/MCB.01321-14
Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor. Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, Accepted. DOI: 10.1021/ar500370v (IF: 24.348)
Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces. Kim, J.; Kim, H.; Park, S.B.* J. Am. Chem. Soc. 2014 136(42), 14629–14638
Discovery of carbohybrid-based 2-aminopyrimidine analogues as multi-stage active antimalarial agents using image-based cytological profiling assay. Lee, S.; Lim, D.; Lee, E.; Lee, N.; Lee, H.-G.; Cechetto, J.; Liuzzi, M.; Freitas-Junior, L.H.; Song, J.S.; Bae, M.A.; Oh, S.; Ayong, L.*; Park, S.B.* J. Med. Chem. 2014 57(17), 7425–7434.
Target Identification Revealed a Direct HMGB2-binding Small Molecule with an Anti-neuroinflammatory Effect. Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060. (IF: 13.217).
A novel non-agonistic PPARγ ligand, CDK104 blocks PPARγ phosphorylation by CDK5 and improves insulin sensitivity. Choi, S.-S.; Kim, E.S.; Koh, M.; Lee, S.-J.; Lim, D.; Yang, Y.R.; Jang, H.-J.; Park, S.B.; Suh, P.-G.; Choi, J.H.* J. Biol. Chem. 2014 289(38), 26618–26629.
Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3. Park, J.; Um, J.I.; Jo, A.; Lee, J.; Jung, D.-W.; Williams, D.*; Park, S. B.* Chem. Commun. 2014 50(66), 9251–9254
Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy. Koh, M.; Park, J.; Koo, J.Y.; Lim, D.; Cha, M.Y.; Jo, A.; Choi, J.H.; Park, S. B.* Angew. Chem. Int. Ed. 2014, 53(20), 5102–5106
Inverse agonist of ERRgamma controls Salmonella typhimurium infection by modulating host iron homeostasis. Kim1, D.-K.; Jeong, J.-H.; Lee, J.-M.; Kim, K.S.; Park, S.-H.; Kim, Y.D.; Koh, M.; Shin, M.; Jung, Y.S.; Kim, H.-S.; Lee, T.-H.; Oh, B.-C.; Kim, J. I.; Park, H.T.; Jeong, W.-I.; Lee, C.-H.; Park, S.B.; Min, J.-J.; Jung, S.-I.; Choi, S.-Y.; Choy, H.E.*; Choi, H.-S.* Nature Medicine 2014, 20, 419–424. (IF: 22.864)
Anti-inflammatory effects of a-galactosylceramide analogs in activated microglia; involvement of p38 MAPK signaling pathway. Jeong, Y.-H.; Kim, Y.; Song, H.; Park, S.B.*; Kim, H.-S.* PLoS ONE 2014 9(2), e87030 (IF: 3.730)
Rational Perturbation of Fluorescence Quantum Yields in Emission-tunable and predictable Fluorophores, Seoul-Fluors, via Facile Synthesis using C-H Activation. Choi, E.; Kim, E.; Lee, Y.; Jo, A.; Park, S. B.* Angew. Chem. Int. Ed. 2014 53(5), 1346-1350 (IF: 13.734)
Synthesis and Library Construction of privileged tetra-substituted ∆5-2-oxopiperazine as β-turn structure mimetics. Kim, J.; Lee, W. S.; Koo, J.; Lee, J.; Park, S. B.* ACS Combinatorial Sciences 2014 16(1), 24–32 (IF: 3.636)
Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4. Kwon, D.H.; Eom, G.H.; Kim, D.K.; Koo, J.; Lim, H.S.; Nam, G.-I.; Kim, K.K.; Lee, I.-K.; Park, S.B.; Choi, H.-S.; Kook, H.* Journal of Molecular and Cellular Cardiology 2013 65, 88-97 (IF: 5.150)
Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles. Kim, H.; Tung, T. T.; Park, S. B.* Org. Lett. 2013 15(22), 5814–5817(IF: 6.142)
Measurement of Accumulation Kinetics for Lipid Droplets in Microalgae using SF44. Park, J.W.; Na, S. C.; Lee, Y.; Lee, S.; Park, S. B.*; Jeon, N.R.* Energies 2013 6(11), 5703–5716 (IF: 1.844)
Synthesis and Biological Evaluation of α-Galactosylceramide Analogues with Heteroaromatic Rings and Varying Positions of Phenyl Group in the Sphingosine Backbone. Kim, Y.; Oh, K.; Song, H.; Lee, D.-S.; Park, S. B.* J. Med. Chem. 2013 56(17), 7100–7109(IF: 5.614)