Lee, Chulbom - Seoul National University

个人简介

Education BS/MS. Chemistry, Seoul National University 1990 Ph.D. Chemistry, Stanford University, California, USA, 1998 Research Experiences Associate Professor, Department of Chemistry, Seoul National University, Korea , 2008-Present Assistant Professor, Department of Chemistry, Princeton University, New Jersey, USA, 2001-2008 US Army Cancer Research Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, New York, USA, 1999-2001 Teaching and Research Assistant, Institute for Basic Research, 1991-1992

研究领域

Our program is broadly based on modern organic chemistry (organic synthesis, organometallic chemistry, asymmetric catalysis, natural product total synthesis, bioorganic chemistry). We are developing synthetic tools (reactions and reagents) and networks of reactions (synthetic strategies) for efficient and selective chemical synthesis. In particular, we focus on the development of chemical transformations that can resolve longstanding synthetic problems and offer new mechanistic vistas for future development in organic synthesis. Our investigations are also concerned with the synthesis of natural products with complex molecular architecture and significant biological activities. Our goal is to establish synthetic roadmaps to the target molecules, to evolve new synthesis logics, and to uncover the molecular bases for the peculiar properties of these compounds. 1. New Reaction Development The research in this area involves discovering, understanding, and exploiting new catalyst systems that effect bond formation with control of chemo-, regio- and stereoselectivities. Our approach is to identify novel reactivities and mechanistic motifs of transition metal-mediated processes to develop conceptually new reactions of broad synthetic utility. Specific topics include the development of stereoselective carbon-heteroatom bond-forming reactions for the asymmetric synthesis of chiral ethers and amines, and new cyclization reactions using alkynes via transition metal vinylidene mediated catalysis. 2. Total Synthesis of Natural Products Target molecules in our lab include a variety of natural products possessing interesting structural, biological, and physical properties. In each project, we probe the feasibility of unprecedented reactions or untested networks of reactions in complex structural and functional settings. By undertaking these chemical synthesis investigations, we aim to develop innovative new chemistry that will be of great utility in broader contexts. Thus, our endeavor will not only advance synthetic science but also foster opportunities for further biomedical explorations utilizing these molecular agents.

近期论文

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Rhodium-Catalyzed Tandem Addition–Cyclization–Rearrangement of Alkynylhydrazones with Organoboronic Acids Kyoungmin Choi, Hoyoon Park and Chulbom Lee J. Am. Chem. Soc. 140, 10407-10411 (2018). Stereoselective allylic reduction via one-pot palladium-catalyzed allylic sulfonation and sulfinyl retro-ene reactions Hyun-Suk Um, Jungki Min, Taeyang An, Jin Choi and Chulbom Lee Org. Chem. Front. 5, 2158-2162 (2018). Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis Taehoon Kim, Stefan J. McCarver, Chulbom Lee and David W. C. MacMillan Angew. Chem. Int. Ed. 57, 3488-3492 (2018). Synthesis of the C1–C10 Fragment of Madeirolide A Sunghyun Hwang, Inhwan Baek and Chulbom Lee Org, Lett. 18, 2154-2157 (2016). Base-Catalyzed One-Pot Synthesis of UnsymmetricalFluorenes from Aromatic ortho-Dialdehydes and 1,3-Dicarbonyl Compounds Ue Ryung Seo, Young Keun Chung and Chulbom Lee ChemCatChem 8, 1051-1054 (2016). Rhodium-catalyzed tandem addition–cyclization of alkynylimines Kyoungmin Choi, Jung Min Joo, Chulbom Lee Tetrahedron 71, 5910-5917 (2015). Heme-binding-mediated Negative Regulation of the Tryptophan Metabolic Enzyme Indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2 Young-Kwan Lee, Hoon Bok Lee, Dong-Mi Shin, Min Jueng Kang, Eugene C Yi, Seungjoo Noh, Jaewoo Lee, Chulbom Lee, Chang-Ki Min, and Eun Young Choi Experimental & Molecular Medicine 46, e121 (2014). DOI A Paradoxical Pattern of Indoleamine 2,3-dioxygenase Expression in the Colon Tissues of Patients with Acute Graft-versus-host Disease Gyeongsin Park, Yeong-Jin Choi, Sung-Eun Lee, Ji-Young Lim, Chulbom Lee, Eun Young Choi, and Chang-Ki Min Experimental Hematology 42, 734-740 (2014). Nitrogen-centered Radical-mediated C-H Imidation of Arenes and Heteroarenes via Visible Light Induced Photocatalysis Hyejin Kim, Taehoon Kim, Dong Gil Lee, Sang Weon Roh, and Chulbom Lee Chem. Commun. 50, 9273-9276 (2014). Tandem Diels-Alder and Retro-Ene Reactions of 1-Sulfenyl- and 1-Sulfonyl-1,3-dienes as a Traceless Route to Cyclohexenes Jin Choi, Hoyoon Park, Hyun Jung Yoo, Sinae Kim, Erik J. Sorensen, and Chulbom Lee J. Am. Chem. Soc. 136, 9918-9921 (2014). Rhodium-Catalyzed Oxygenative [2 + 2] Cycloaddition of Terminal Alkynes and Imines for the Synthesis of β-Lactams Insu Kim, Sang Weon Roh, Dong Gil Lee, and Chulbom Lee Org, Lett. 16, 2482-2485 (2014).