Pottie, Ian - St. Mary's University - Department of Chemistry

研究领域

Natural product synthesis, asymmetric synthesis, Henry reaction, Diels-Alder reaction, Alzheimer's disease, multiple sclerosis.

近期论文

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Pottie, I. R.; Nandaluru, P. R.; Benoit, W. L.; Miller, D. O.; Dawe, L. N.; Bodwell, G. J. “Synthesis of 6H-Dibenzo[b,d]pyran-6-ones Using the Inverse Electron Demand Diels-Alder Reaction” J. Org. Chem.2011, 76, 9015-9030. DOI: 10.1021/jo201775e Pottie, I. R.; Nandaluru, P. R.; Bodwell, G. J. "An Inverse Electron-Demand Diels-Alder-Based Total Synthesis of Urolithin M7" Synlett, 2011, 2245-2247. DOI: 10.1055/s-0030-1261203 Pottie, I. R.; Higgins, E. A.; Blackman, R. A.; Macdonald, I. R.; Martin, E.; Darvesh, S. "Cysteine Thioesters as Myelin Proteolipid Protein Analogues to Examine the Role of Butyrylcholinesterase in Myelin Decompaction" ACS Chem. Neurosci. 2011, 2, 151-159. DOI: 10.1021/cn100090g MacDonald, F. K.; Carneiro, K. M. M; Pottie, I. R. "The first example of trimethylsilyl methylenenitronate reacting with aldehydes under an apparent Mukaiyama nitro-aldol reaction" Tetrahedron Lett. 2011, 52, 891-893. DOI: 10.1016/j.tetlet.2010.12.056 Macdonald, I. R.; Reid, G. A.; Joy, E. E.; Pottie, I. R.; Matte, G.; Burrell, S.; Mawko, G.; Martin, E.; Darvesh, S. "Synthesis and Preliminary Evaluation of Piperidinyl and Pyrrolidinyl Iodobenzoates as Imaging Agents for Butyrylcholinesterase." Mol. Imag. Biol. 2011, 13, 1250-1261. DOI: 10.1007/s11307-010-0448-0 Pottie, I. R.; Crane, S. N.; Gosse, A. L.; Miller, D.; Burnell, D. J. "Geminal acylation of alpha-heterosubstituted cyclohexanones and their ketals" Can. J. Chem. 2010, 88, 1118-1124. DOI: 10.1139/V10-097 Darvesh, K. V.; Pottie, I. R.; McDonald, R. S.; Martin, E.; Darvesh, S. Targetting butyrylcholinesterase for Alzheimer’s disease therapy. In Quantuum Biochemistry Matta, Cherif, ed.; Wiley-VCH, Germany, 2010, Vol. 2, pp 757-780. DOI: 10.1002/9783527629213.ch28 Darvesh, S.; Pottie, I. R.; Darvesh, K. V.; McDonald, R. S.; Walsh, R.; Conrad, S.; Penwell, A.; Mataija, D.; Martin, E. "Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants" Bioorg. Med. Chem. 2010, 18, 2232-2244. DOI: 10.1016/j.bmc.2010.01.066 Pottie, I.R.; Martin, E.; Joy, E.E.; Macdonald, I.R.; Darvesh, S. “Butyrylcholinesterase Ligands as Diagnosis tools for Diseases of the Nervous System.” Provisional Patent US:61/092,861, issued August 29, 2008. Carneiro, K. M. M.; MacDonald, F. K.; Pottie, I. R. “An Investigation In The Formation and Reactivity Of Borodicyclohexyl Methylenenitronate” J. Mex. Chem. Soc. 2006, 50 (S1), 184. Abourahma, H.; Bodwell, G. J.; Moulton, B.; Pottie, I. R.; Walsh, R. B.; Zaworotko, M. J. “Polymeric Metal-Organic Calixarenes from [Cu2(dicarboxylate)2]4 Building Blocks: Structural Diversity via Atropisomerism” Cryst. Growth Des. 2003, 3, 513-519. DOI: 10.1021/cg0340345 Pottie, I. R.; Vaughan, K.; Zaworotko, M. J. “A molecular recognition event in the reaction of a diazonium salt with N,N-dimethylethylenediamine” J. Chem. Cryst. 2001, 31, 143-148. DOI: 10.1023/A:1014363720456 Bodwell, G. J.; Pi, Z.; Pottie, I. R. “Electron Deficient Dienes. 2. One Step Synthesis of a Coumarin-fused Electron Deficient Diene and its Inverse Electron Demand Diels-Alder Reactions with Enamines” Synlett 1999, 477-479. DOI: 10.1055/s-1999-2645 Hooper, D. L.; Pottie, I. R.; Vacheresse, M.; Vaughan, K. “1,2-bis-(1-Aryl-3-alkyltriazen-3-yl)ethanes and Related Compounds” Can. J. Chem. 1998, 125-135. DOI: 10.1139/cjc-76-1-125 Pottie, I. R.; Sharma, C. V. K.; Vaughan, K.; Zaworotko, M. J. “Crystal structures of 2 1,2-bis-(1-aryl-3-methyltriazen-3-yl)ethanes with aryl substituents of opposite polarity” J. Chem. Cryst. 1998, 28, 5-10. DOI: 10.1023/A:1021714316063